Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.14365/5577
Title: Manifestations of walking fatigability in people with multiple sclerosis based on gait quality and distance walked during the six minutes walking test
Authors: Santinelli, F.B.
Abasıyanık, Z.
Ramari, C.
Gysemberg, G.
Kos, D.
Pau, M.
Kalron, A.
Keywords: Fatigue
Gait analysis
Gait quality
Multiple sclerosis
Walking fatigability
adult
aged
anthropometry
Article
assessment of humans
cardiovascular disease
clinical trial (topic)
cognition
controlled study
cross-sectional study
Expanded Disability Status Scale
fatigue
Fatigue Impact Scale
female
gait
human
kinematics
leg circumduction
male
Modified Fatigue Scale
MS Walking Scale 12
multiple sclerosis
Multiple Sclerosis Walking Scale
prevalence
six minute walk test
step time
step time variability
stride length
Symbol Digit Modality Test
Timed 25-foot walking
walking
walking distance
walking fatigability
walking speed
Publisher: Elsevier B.V.
Abstract: Background: Distance walking fatigability (DWF) in people with multiple sclerosis (pwMS) is defined as a decrease in the distance walking over time. However, declines in gait quality (i.e., gait quality fatigability- GQF) may occur independently or alongside DWF. Objective: i) to investigate how walking fatigability manifests and its prevalence in pwMS; ii) to describe the temporal pattern of the changes of specific gait characteristics during the 6-minute walking test (6MWT) Methods: Eighty-eight pwMS (EDSS 4[0–6.5], 49[21–70] years) and 47 healthy controls (HC- 46[25–60] years) performed the 6MWT wearing inertial measurement units. Gait characteristics (stride length, sensor-based gait speed, cadence, double support, step duration, stance phase, step duration asymmetry, step duration variability, foot-strike, toe-off, and leg circumduction) and walking distance were recorded in 1-minute intervals. A fatigability index was calculated by comparing the last and first minute of the 6MWT to identify abnormal worsening based on cutoff scores. The manifestation of walking fatigability was counted. The temporal pattern of worsening of gait characteristics during the 6MWT was examined in pwMS exceeding the cutoff values, compared to pwMS without abnormal changes and HC, using a two-way ANOVA (group vs. minutes) Results: Thirty-five pwMS presented both DWF and GQF, 2 presented isolated DWF, 27 presented isolated GQF, and 24 presented non-walking fatigability. PwMS having GQF presented worsening in gait characteristics (cadence, step duration, step duration variability, or toe-off angle) from minute 2 onwards of the 6MWT, while HCs and pwMS without abnormal changes stabilized gait from minute 2 towards the end of the 6MWT. Conclusion: Walking fatigability in pwMS manifests not only as a decrease in walking distance but also as changes in gait quality. Understanding changes in gait characteristics during walking can help tailor rehabilitation interventions. © 2024 Elsevier B.V.
URI: https://doi.org/10.1016/j.msard.2024.105909
https://hdl.handle.net/20.500.14365/5577
ISSN: 2211-0348
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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