WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/5

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Turkish Validity and Reliability of PRAFAB Questionnaire: A Validation Study
(Bayrakol Medical Publisher, 2026) Ipekten, Funda; Berghmans, Bary; Ozengin, Nuriye; Yesilyurt, Seda Yakit; Yildiz, Elif Duygu; Cankaya, Hatice
Aim: PRAFAB-Questionnaire is a short, responsive, and practical tool that assesses subjective severity and the impact of urinary incontinence (UI). The aim of this study was to conduct a Turkish adaptation, validity and reliability of the PRAFAB-Questionnaire. Methods: A total of 55 women with stress and mixed UI complaints were included in the study. The English version of the questionnaire was translated into Turkish. Explanatory and confirmatory factor analysis, concurrent validity (with Incontinence Severity Index (ISI) and Visual Analogue Scale (VAS) for body/selfimage) and face validity were conducted for validity. Women were asked to refill the questionnaire after one week. Test-retest results and Cronbach's alpha coefficient were calculated for reliability analysis. Results: Explanatory factor analysis revealed that the questionnaire had only one factor, and confirmatory factor analysis confirmed this single factor. There was a moderate positive correlation between PRAFAB-Questionnaire and VAS scores (r = 0.690, p < .001). There was a strong positive correlation between PRAFAB-Questionnaire and ISI (r = 0.741, p < .001). PRAFAB also had face validity. Reliability between PRAFAB-Questionnaire items and total score was good to excellent (ICC: 0.807-0.925). Cronbach's alpha coefficient was 0.720. Conclusion: Turkish version of PRAFAB-Questionnaire has been shown valid and reliable. The responsiveness of the questionnaire needs to be evaluated for different types of UI for further studies.
Trolling or Astroturfing? Tracing Terminological Drift and Its Democratic Costs in Turkish Political Journalism
(Routledge Journals, Taylor & Francis Ltd, 2026) Uzunoglu, Sarphan
The terms trolling and astroturfing are widely used in Turkish political journalism but are often conflated, producing significant conceptual ambiguity and normative confusion. This article offers a theoretical and empirical intervention to clarify these forms of digital manipulation and to examine how they are framed in media discourse. Drawing on a stratified-random sample of 200 news and opinion articles published between January 2023 and April 2025, the study applies media content analysis across seven ideologically diverse Turkish outlets. Articles were coded using a six-dimension schema addressing conceptual framing, actor and sponsorship cues, functional intent, astroturf linkages, normative stance, and solution discourse. Findings reveal a pervasive pattern of label inflation, with trolling used as a catch-all term encompassing both decentralized harassment and coordinated, sponsor-driven propaganda. Explicit references to sponsorship were rare, and discussions of platform governance or policy solutions were largely absent. The article proposes a revised conceptual framework to distinguish trolling from astroturfing more precisely. It contributes to broader discussions about hybrid influence campaigns, media framing strategies, and the role of journalism in sustaining democratic accountability in digitally polarized environments.
The Statistics of Q-Statistics
(MDPI, 2024) Borges, Ernesto P.; Tirnakli, Ugur; Eroglu, Deniz; Boghosian, Bruce M.
Almost two decades ago, Ernesto P. Borges and Bruce M. Boghosian embarked on the intricate task of composing a manuscript to honor the profound contributions of Constantino Tsallis to the realm of statistical physics, coupled with a concise exploration of q-Statistics. Fast-forward to Constantino Tsallis' illustrious 80th birthday celebration in 2023, where Deniz Eroglu and Ugur Tirnakli delved into Constantino's collaborative network, injecting renewed vitality into the project. With hearts brimming with appreciation for Tsallis' enduring inspiration, Eroglu, Boghosian, Borges, and Tirnakli proudly present this meticulously crafted manuscript as a token of their gratitude.
Transcultural Nursing Care, Religion, and Compassion: A Holistic Path toward Reduced Inequalities
(Univ Sao Paolo, 2026) Digrak, Ebru; Tezel, Ayfer
Objective: To examine the relationships between cultural competence, compassion, and religion among nursing students. Method: A cross-sectional study was conducted among third and fourth-year nursing students enrolled in a state university in Türkiye during the 2022-2023 academic year. A total of 422 students who met the inclusion criteria and agreed to participate completed the Personal Information Form, Individual Religion Inventory, Compassion Scale, and Cultural Competence Assessment Tool (CCATool). Data were analyzed using descriptive statistics, correlation analyses, and group comparison tests. Results: Gender was found to significantly influence cultural competence, compassion, and religion scores. Additionally, cultural competence was negatively correlated with both compassion and religion among the participating students. Conclusions: The findings highlight a concerning area within nursing education, emphasizing the need to enhance cultural competence alongside fostering compassion and religion. These results indicate the importance of developing nursing curricula that support quality education and contribute to reduced inequalities in healthcare delivery.
The Reliability and Validity of the Personalıty Inventory for DSM-5-Short Form (PID-5-SF) in Turkish Adolescents
(Guilford Publications Inc, 2026) Bilgic, Ayhan; Coskun, Fatma; Akca, Omer Faruk; Sharp, Carla
The 100-item short form of the Personality Inventory for DSM-5 (PID-5-SF) has been translated into various languages and validated across cultures and age groups, but research on adolescents is limited. This study evaluated the psychometric properties of the Turkish version (PID-5-SF-TR) in a sample of 349 adolescents (181 community, 168 clinical). Participants also completed the Personality Belief Questionnaire-Short Form (PBQ-SF) and the Big Five Inventory (BFI). Clinical participants had higher facet scores than community participants. Exploratory factor analysis revealed a five-factor structure for both groups. Cronbach's alpha coefficients ranged from 0.72 to 0.86 in the clinical group and from 0.73 to 0.87 in the community group. PID-5-SF-TR domains correlated significantly with related BFI dimensions, except for Openness and Psychoticism. Corresponding PBQ-SF and PID-5-SF-TR subscales were significantly correlated. Test-retest reliability over 5 months showed coefficients ranging from r = 0.30 to r = 0.67. Findings support the reliability and validity of using the PID-5-SF-TR when diagnosingTurkish adolescents.
The Relationship between Early Feeding Skills and General Movements of Preterm Infants in the Neonatal Intensive Care Unit
(Turkish J Pediatrics, 2026) Olgun, Tansu Birinci; Dilek, Mustafa; Yesilyurt, Seda Yakit; Tas, Seda Ayaz; Tezcan, Sezen
Background. Early feeding skills and general movements (GMs) are negatively affected by hypotonia due to prematurity. Interventions for feeding skills can be guided by understanding the relationship between feeding skills and GMs. In the light of this, the study focused on understanding the relationship between early feeding skills and preterm infants' GMs in the neonatal intensive care unit (NICU). Methods. Participants in this cross-sectional study were forty infants with a postmenstrual age of 34-37 weeks who were hospitalized in the NICU at Abantİzzet Baysal University Training and Research Hospital. The data consisted of demographic characteristics (birth weight, gestational age, date of birth, age, and sex), feeding skills, assessed with the Early Feeding Skills Assessment Tool, and GMs, assessed with the General Movement Assessment. Results. A strong correlation was found between the Oral-Motor Function subscale of the Early Feeding Skills Assessment Tool and the Upper Limbs subscale of the General Movements Motor Optimality Score (rho=0.74, p=0.001). Among the demographic characteristics, only maternal age was associated with feeding skills. A weak correlation was determined between the Physiologic Stability subscale of the Early Feeding Skills Assessment Tool and maternal age (rho=0.34 p=0.03). Conclusions. This study reveals the relationship between feeding skills and general movement of preterm infants at NICU. GMs of upper extremity were found to positively affect feeding skills. This process may be accelerated by interventions to improve the GMs of upper extremity during the transition to oral feeding.
The Prognostic Impact of 18F-FDG PET SUVmax in Patients with Non-Small Cell Lung Cancer
(Bayrakol Medical Publisher, 2026) Gulcek, Ilham; Agar, Mehmet; Kalkan, Muhammed; Celik, Muhammet Reha; Ulutas, Hakki
Aim: The maximum standardized uptake value (SUVmax) of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) enhances clinical prediction in non-small cell lung cancers (NSCLC). This study aimed to investigate whether SUVmax could serve as a prognostic factor and improve clinical prognostication. Methods: This retrospective study included 86 patients with NSCLC who underwent surgical resection. Using receiver operating characteristic (ROC) analysis, the SUVmax cut-off value was 12.3. Patients with SUVmax values below 12.3 were classified as Group A, while those with values above 12.3 were designated as Group B. Survival analyses were performed using the Kaplan-Meier method. Overall survival was defined as the time from diagnosis to death. Confidence intervals were reported at 95%, and a p-value of <0.05 was considered statistically significant. The variables analyzed for survival included gender, age, surgical approach, histopathological subtype of lung cancer, cancer stage, T score, and N score. Results: Survival analyses revealed statistically significant associations between SUVmax and age (p=0.043), gender (p=0.060), surgical approach (p=0.037), and histopathological subtype (p=0.026). Due to insufficient sample size within subgroups, separate p-values were calculated for each stage, T score, and N score. Based on the obtained p-values, no statistically significant correlation was found between SUVmax and overall survival across different stages, T scores, or N scores, except for stage 1A and T1b. Conclusion: SUVmax contributes to determining appropriate diagnostic and treatment protocols and aids in predicting the prognosis of the disease.
The Morphology of Continuity: An Analytical Documentation of Vernacular Architecture in Phoenix Rural Settlements
(MDPI, 2026) Cakan, Munire Rumeysa; Kishali, Emre; Yaman, Asil
Rural architectural systems in the Mediterranean reflect a long-term entanglement between human agency, material conditions, and environmental constraints. This study uses this framework to explore architectural continuity in settlements near ancient Phoenix in Türkiye. While scholarly focus often remains on monumental ruins, it aims to examine how rural building practices, such as stone masonry, traditional carpentry, and the reuse of spolia, have persisted since antiquity. The methodology combines UAV photogrammetry, GIS analysis, and oral histories to reveal spatial patterns and craft traditions across generations. The findings show that structures are transmitted through technical knowledge, with stone and timber co-evolving with local livelihoods. By documenting the structural logic and embedded intangible knowledge of seasonal settlements like Fenaket and Büğüş, the study identifies a 'continuity through change' paradigm rooted in circular resilience and adaptive reuse, This study emphasizes the need for conservation strategies that integrate digital documentation with community experience to preserve the cross-border cultural landscape of the Aegean region amid environmental threats and the decline in craftsmanship, thereby sustaining it as a dynamic living culture.
Structured Implementation of Cervical Cancer Screening & Dysplasia Treatment in Ghana: Implementing Sustainable Care in a Low-Resource Setting
(Elsevier, 2026) Pan, Teresa Lucia; Bowden, Sarah; Mwinbe-Ere, Vera; Ellis, Laura Burney; Taumberger, Nadja; Friko, Ibrahim; Gultekin, Murat
Symmetric Orthogonalization and Probabilistic Weights in Resource Quantification
(Tubitak Scientific & Technological Research Council Turkey, 2026) Torun, Gokhan
Transforming nonorthogonal bases into orthogonal ones often compromises essential properties or physical meaning in quantum systems. Here, we demonstrate that Löwdin symmetric orthogonalization (LSO) outperforms the widely used Gram-Schmidt orthogonalization (GSO) in characterizing and quantifying quantum resources, with particular emphasis on coherence and superposition. We employ LSO both to construct an orthogonal basis from a nonorthogonal one and to obtain a nonorthogonal basis from an orthogonal set, thereby mitigating ambiguity related to the basis choice in defining quantum coherence. Unlike GSO, which depends on the ordering of input states, LSO applies a symmetric transformation that treats all vectors equally and minimizes deviation from the original basis. This procedure yields basis sets with enhanced stability, preserving the closest possible correspondence to the original physical states while satisfying orthogonality. Building on LSO, we also introduce Löwdin weights - probabilistic weights for nonorthogonal representations that provide a consistent measure of resource content. We explicitly contrast these with Chirgwin-Coulson weights, demonstrating that Löwdin weights ensure nonnegativity, a prerequisite for information-theoretic measures. These weights further enable the quantification of coherence and the characterization of superposition, providing a degree of superposition as a distinct measure, as well as facilitating the assessment of state delocalization through entropy and participation ratios. Our theoretical and numerical analyses confirm LSO's superior preservation of quantum state symmetry and resource characteristics, underscoring the critical role of orthogonalization methods and Löwdin weights in resource theory frameworks involving nonorthogonal bases.
Romiplostim for Chemotherapy-Induced Thrombocytopenia (CIT) in Colorectal, Gastroesophageal, and Pancreatic Cancers: A Global, Phase 3, Randomized, Placebo-Controlled Trial (RCT)
(Lippincott Williams & Wilkins, 2025) Munoz, Cesar; Soff, Gerald A.; Korantzis, Ippokratis; Al-Samkari, Hanny; Gonzalez Astorga, Beatriz; Arslan, Cagatay; Geredeli, Caglayan
Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia
(Massachusetts Medical Soc, 2026) Munoz, Cesar; Soff, Gerald A.; Korantzis, Ippokratis; Astorga, Beatriz Gonzalez; Al-Samkari, Hanny; Arslan, Cagatay; Geredeli, Caglayan
Background Chemotherapy-induced thrombocytopenia (CIT) is a common complication of chemotherapy that is associated with bleeding, reduced relative dose intensity, and potentially worse outcomes. No widely available therapies are approved for CIT. Methods We conducted a phase 3, international, double-blind, randomized, placebo-controlled trial involving patients with persistent CIT (platelet count, <= 85 & times;109 per liter on trial day 1) who were receiving oxaliplatin-based multiagent cytotoxic chemotherapy for gastrointestinal cancers. Patients were randomly assigned in a 2:1 ratio to receive romiplostim or placebo for three chemotherapy cycles. The primary end point was the absence of CIT-induced modifications of the chemotherapy dose (reduction, delay, omission, or discontinuation) in both the second and third chemotherapy cycles. Results Of the 165 patients who underwent randomization (109 in the romiplostim group and 56 in the placebo group), 75% had colorectal cancer, 13% had gastroesophageal cancer, and 12% had pancreatic cancer; 72% of the patients in the romiplostim group and 61% of those in the placebo group had stage 4 disease. The percentage of patients with no CIT-induced modifications of the chemotherapy dose was 84% (92 of 109 patients) with romiplostim and 36% (20 of 56 patients) with placebo, which corresponded to an odds ratio of 10.16 (95% confidence interval [CI], 4.44 to 23.72; P<0.001) and a risk ratio of 2.77 (95% CI, 1.78 to 4.30; P<0.001). Adverse events of grade 3 or higher occurred in 37% of the patients who received romiplostim and in 22% of those who received placebo, which primarily reflected chemotherapy effects. Adverse events that were considered by the investigator to be related to romiplostim or placebo occurred in 12% of patients who received romiplostim and in 7% who received placebo, with the most frequent being nausea (2% in each group) and headache (2% in the romiplostim group); none were serious or led to death or discontinuation of romiplostim, placebo, or chemotherapy. Thromboembolic events occurred in 2% of patients who received romiplostim and in no patients who received placebo. Conclusions In this phase 3, placebo-controlled trial, romiplostim was efficacious in treating CIT. (Funded by Amgen and the Biomedical Advanced Research and Development Authority; RECITE ClinicalTrials.gov number, NCT03362177.)
Role of Postoperative Renal Ultrasound in Identifying Ureteral Injury despite Normal Intraoperative Jet Flow
(Galenos Publ House, 2026) Ozer, Pinar Tugce; Ileri, Alper; Inan, Abdurrahman Hamdi; Kantarci, Sercan; Yildirim, Fatih; Dagli, Ugurcan; Karabulut, Alaattin
Objective: This study evaluated the diagnostic utility of early postoperative renal ultrasound in detecting ureteral injury in patients who had undergone total laparoscopic hysterectomy (TLH) for benign indications, despite documented normal intraoperative ureteral jet flow on cystoscopy. Materials and Methods: In this retrospective cohort study at a high-volume tertiary center, data from 3,170 patients who underwent TLH between January 2022 and October 2025 were analyzed. Inclusion required normal bilateral ureteral jet flow on routine intraoperative cystoscopy, a renal ultrasound within the first 24 postoperative hours, and at least 30 days of clinical follow-up. The primary outcome was the diagnostic yield of postoperative ultrasound for identifying ureteral injuries not apparent during surgery. Injuries were confirmed by advanced imaging or surgical exploration. Results: The overall ureteral injury rate was 0.79% (n=25). Of these injuries, eight were diagnosed intraoperatively, while seventeen occurred despite documented normal bilateral ureteral jet flow during the procedure. Among the latter group, renal ultrasonography performed on postoperative day 1 detected 14 injuries, representing 56% of all injuries. Three injuries (12%) presented later, around postoperative day 10, and were not identified on initial imaging. Early postoperative ultrasonography demonstrated good sensitivity and a high negative predictive value as a screening tool. Comparison with preoperative baseline imaging enhanced diagnostic performance in identifying new-onset obstruction, particularly newly developed pelviectasis. Conclusion: Normal intraoperative ureteral jet flow does not preclude ureteral injury, particularly those with delayed presentation, such as thermal damage. Early postoperative renal ultrasonography is a valuable non-invasive screening tool that identifies a significant proportion of injuries missed by cystoscopy alone. Comparative evaluation of routine postoperative ultrasonography with preoperative imaging may provide a meaningful contribution to the early diagnosis of ureteral injury following TLH.
Phase 1b/2 KEYNOTE-365 Cohort I: Pembrolizumab (Pembro) plus Carboplatin and Etoposide Chemotherapy (Chemo) or Chemo Alone for Metastatic Neuroendocrine Prostate Cancer (NEPC)
(Lippincott Williams & Wilkins, 2025) Gonzalez-Billalabeitia, Enrique; Von Amsberg, Gunhild; Arslan, Cagatay; Mehra, Niven; Emmenegger, Urban; Robbrecht, Debbie G. J.; Yu, Evan Y.
Nonadditive Entropies and Nonextensive Statistical Mechanics
(MDPI, 2025) Tirnakli, Ugur
Motivations and Treatment Shifts in Older Multiple Sclerosis Patients: Understanding Treatment Changes after Age 50
(Elsevier, 2025) Kaya, Ergi; Caliskan, Can; Zengin, Ela Simay; Simsek, Yasemin; Ozakbas, Serkan
Leveraging Point-of-View Camera and MediaPipe for Objective Hyperactivity Assessment in Preschool ADHD
(Frontiers Media SA, 2026) Kayis, Hakan; Gedizlioglu, Cinar
Background Attention-Deficit/Hyperactivity Disorder (ADHD) often emerges in early childhood, with hyperactivity and impulsivity constituting the most prominent symptoms during the preschool period. Current assessment approaches rely largely on clinical interviews and behavior rating scales, which are susceptible to subjectivity and contextual bias. Objective, ecologically valid, and low-burden methods for quantifying hyperactivity in preschool settings remain limited.Methods This observational, cross-sectional study investigated whether movement-based features extracted from teacher-worn point-of-view (POV) video recordings could differentiate preschool children at risk for ADHD-related hyperactivity from non-hyperactive peers. Fifty-one preschool children (48-60 months) participated in a standardized, three-minute storytelling interaction conducted in a familiar classroom environment. Video recordings were processed using MediaPipe pose estimation to derive region-specific movement indices across multiple body segments. Group differences were examined using statistical analyses. In addition, supervised machine learning models were applied to evaluate classification performance based on movement features.Results Children in the hyperactivity-risk group exhibited significantly greater movement across several body regions, particularly distal upper- and lower-limb segments, compared to non-hyperactive peers. Machine learning analyses indicated promising classification performance, with the support vector machine achieving an accuracy of 84.31%, sensitivity of 80.0%, specificity of 87.10%, and an area under the receiver operating characteristic curve (AUC) of 0.83. Permutation-based feature importance analyses highlighted distal limb movements as the most informative features for classification.Conclusions These findings suggest that POV-based, vision-driven assessment provides a promising, objective, and ecologically valid approach for quantifying hyperactivity-related motor behavior in preschool children. While not intended as a standalone diagnostic tool, this low-burden framework may serve as a valuable complement to existing screening practices and support early identification efforts in educational settings.
Long Noncoding RNA NEAT1 Interacts with the miR-3648 Axis in Imatinib Resistant Chronic Myeloid Leukemia Cell Model
(Springer Nature, 2025) Doluca, Osman; Kayabasi, Cagla; Mutlu, Zeynep
Integrating Reproductive and Clinical Variables to Predict Postpartum Disability Outcomes in Multiple Sclerosis Using Machine Learning
(Elsevier Sci Ltd, 2026) Samadzade, Ulvi; Emec, Murat; Alizada, Said; Ozcanhan, Mehmet Hilal; Simsek, Yasemin; Ozakbas, Serkan
Background: Pregnancy represents a unique immunological state in women with multiple sclerosis (MS), and postpartum disease reactivation is a major concern. While pregnancy outcomes have been extensively described, the long-term effects of reproductive and obstetric variables on disability progression remain poorly elucidated. Objective: To predict postpartum EDSS-based disability change based on pregnancy-related clinical and demographic variables in women with MS, using validated machine learning models. Methods: This retrospective real-world study included 662 women contributing 909 pregnancies. Engineered features included pre- and post-pregnancy Expanded Disability Status Scale (EDSS) scores, disease duration, maternal age, postpartum relapse, and obstetric variables. Regression and classification models (Random Forest, XGBoost, Elastic Net, Support Vector Classifier) were trained on an 80/20 train-test split with five-fold crossvalidation. Model performance was assessed using R2, mean absolute error (MAE), accuracy, and F1 score. Results: Classification models achieved superior generalization performance (test accuracy 85-88%, F1 0.84-0.87) compared to regression models (test R2 0.31-0.39, MAE 0.41-0.48). Postpartum relapse was the strongest predictor of disability change, followed by disease duration and age at pregnancy. Predictive performance was highest among women with multiple pregnancies, suggesting that cumulative reproductive history carries prognostic value. Obstetric variables such as delivery type and breastfeeding contributed secondary but clinically relevant effects. Conclusion: Machine learning models integrating pregnancy-related variables can provide clinically informative predictions regarding postpartum EDSS-based disability change in women with MS. Postpartum relapse remains the dominant driver of disability change, while reproductive and obstetric factors provide additional prognostic information. These findings highlight the postpartum period as a critical therapeutic window and support incorporating reproductive variables into individualized prognostic frameworks for women with MS.
Integrated Analysis Identifies CCNA2 as a Candidate Diagnostic and Prognostic Biomarker in Oral Tongue Squamous Cell Carcinoma
(Univ Sao Paulo FAC Odontologia Bauru, 2026) Atay, Sevcan; Gumedag, Ceren
Background: Oral tongue squamous cell carcinoma (OTSCC) is an aggressive malignancy with poor prognosis, necessitating reliable biomarkers. Methodology: Genes with significantly higher expression in OTSCC tumor tissues compared to normal tongue tissues were identified via integrated transcriptomic analysis of seven GEO datasets. To assess their diagnostic and prognostic potential, these genes were further characterized using multi-omic and clinical data from the TCGA-OTSCC and CPTAC-OTSCC cohorts. Results: A total of 1,117 genes were found to be upregulated in OTSCC tissues, among which only CCNA2 (Cyclin A2) was significantly associated with both reduced overall survival (OS) and disease-free survival (DFS) in the TCGA-OTSCC cohort (n=128), based on Cox proportional hazards regression and Kaplan-Meier analyses. CCNA2 showed moderate prognostic performance (AUC=0.63 for OS; AUC=0.65 for DFS) and was significantly upregulated in higher-grade tumors (p=0.01) and in deceased patients (p=0.03). No somatic mutations or promoter methylation alterations were observed in CCNA2 based on TCGA data. In CPTAC-OTSCC samples (n=18), CCNA2 protein expression was significantly higher in tumor tissues than in non-tumoral tissues (p <0.0001), with a positive correlation between mRNA and protein levels (r=0.56, p=0.01). Both mRNA and protein forms showed strong diagnostic performance (AUC=0.92 and AUC=0.82, respectively), consistent with observations across multiple tumor types. While CCNA2 protein levels showed prognostic relevance for OS (AUC=0.69, p=0.01), the mRNA-based prediction did not reach statistical significance (AUC=0.63, p=0.36). Functional enrichment analysis of CCNA2 co-expressed genes predicted involvement in cell cycle, mismatch repair, and DNA replication pathways. Additionally, protein-protein interaction analysis positioned CCNA2 as a central hub, suggesting its potential role in OTSCC pathogenesis. Conclusions: These findings indicate that CCNA2 is a promising diagnostic and prognostic biomarker candidate in OTSCC. Given the small size of the CPTAC validation cohort, further studies in larger, independent OTSCC cohorts are warranted to confirm its clinical utility.

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