PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/2

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Citation - WoS: 6
Citation - Scopus: 7
2db: a Proteomics Database for Storage, Analysis, Presentation, and Retrieval of Information From Mass Spectrometric Experiments
(Biomed Central Ltd, 2008) Allmer, Jens; Kuhlgert, Sebastian; Hippler, Michael
Background: The amount of information stemming from proteomics experiments involving (multi dimensional) separation techniques, mass spectrometric analysis, and computational analysis is ever-increasing. Data from such an experimental workflow needs to be captured, related and analyzed. Biological experiments within this scope produce heterogenic data ranging from pictures of one or two-dimensional protein maps and spectra recorded by tandem mass spectrometry to text-based identifications made by algorithms which analyze these spectra. Additionally, peptide and corresponding protein information needs to be displayed. Results: In order to handle the large amount of data from computational processing of mass spectrometric experiments, automatic import scripts are available and the necessity for manual input to the database has been minimized. Information is in a generic format which abstracts from specific software tools typically used in such an experimental workflow. The software is therefore capable of storing and cross analysing results from many algorithms. A novel feature and a focus of this database is to facilitate protein identification by using peptides identified from mass spectrometry and link this information directly to respective protein maps. Additionally, our application employs spectral counting for quantitative presentation of the data. All information can be linked to hot spots on images to place the results into an experimental context. A summary of identified proteins, containing all relevant information per hot spot, is automatically generated, usually upon either a change in the underlying protein models or due to newly imported identifications. The supporting information for this report can be accessed in multiple ways using the user interface provided by the application. Conclusion: We present a proteomics database which aims to greatly reduce evaluation time of results from mass spectrometric experiments and enhance result quality by allowing consistent data handling. Import functionality, automatic protein detection, and summary creation act together to facilitate data analysis. In addition, supporting information for these findings is readily accessible via the graphical user interface provided. The database schema and the implementation, which can easily be installed on virtually any server, can be downloaded in the form of a compressed file from our project webpage.
Citation - WoS: 1
Ablation of Atrioventricular Nodal Reentrant Tachycardia With Focal Cryoablation, Compared With Radiofrequency Ablation: Single-Center Experience
(Arquivos Brasileiros Cardiologia, 2024) Topaloğlu, Caner; Fici, Francesco; Van de Borne, Philippe; Taşkın, Uğur; Doğduş, Mustafa; Saygı, Serkan; Tengiz, İstemihan
Background: The ablation of atrioventricular nodal reentrant tachycardia (AVNRT) with cryoablation is an alternative to radiofrequency (RF) ablation in patients due to the low risk of total atrioventricular block. An increase in early-late recurrences after cryoablation is reported as an important disadvantage. Objectives: In this study, we aimed to compare the acute procedural success and the long-term recurrence rates of patients, with AVNRT who underwent methods. Methods: 73 patients with AVNRT were included in the study: 32 with cryoablation and 41 with RF ablation. There was no statistically significant difference between acute procedural success in methods. The ablation procedure was performed by an operator experienced in arrhythmology. The choice of RF or cryoablation was made in the electrophysiology laboratory based on the material already available during the procedure. After the procedure, the patients were evaluated every 3 months for 2 years in polyclinic control. The significance level adopted in the statistical analysis was 5%. Results: The 2 groups of patients were homogeneous. The fluoroscopy time (p<0.001) was shorter, but atrium-his (p=0.004) and his-ventricular (p=0.015) times were longer in the cryoablation group. There was no significant difference, in terms of acute procedural success, post-procedure jump without a single echo, and presence of echo and jump. Conclusions: Cryoablation requires less fluoroscopy time and is a safe non-inferior alternative to RF ablation in patients with AVNRT. The risk of AV block is a significant problem with the use of RF energy, making it less suitable for use in young and physically active patients.
Citation - Scopus: 1
Ablation of Atrioventricular Nodal Reentrant Tachycardia With Focal Cryoablation, Compared With Radiofrequency Ablation: Single-Center Experience
(2024) Topaloğlu, C.; Fici, F.; Borne, P.V.; Taşkin, U.; Dogdus, M.; Saygi, S.; Tengiz, I.
BACKGROUND: The ablation of atrioventricular nodal reentrant tachycardia (AVNRT) with cryoablation is an alternative to radiofrequency (RF) ablation in patients due to the low risk of total atrioventricular block. An increase in early-late recurrences after cryoablation is reported as an important disadvantage. OBJECTIVES: In this study, we aimed to compare the acute procedural success and the long-term recurrence rates of patients, with AVNRT who underwent methods. METHODS: 73 patients with AVNRT were included in the study: 32 with cryoablation and 41 with RF ablation. There was no statistically significant difference between acute procedural success in methods. The ablation procedure was performed by an operator experienced in arrhythmology. The choice of RF or cryoablation was made in the electrophysiology laboratory based on the material already available during the procedure. After the procedure, the patients were evaluated every 3 months for 2 years in polyclinic control. The significance level adopted in the statistical analysis was 5%. RESULTS: The 2 groups of patients were homogeneous.
Citation - WoS: 9
Citation - Scopus: 8
Abnormal Cross Frequency Coupling of Brain Electroencephalographic Oscillations Related To Visual Oddball Task in Parkinson's Disease With Mild Cognitive Impairment
(Sage Publications Inc, 2023) Bayraktaroglu, Zubeyir; Akturk, Tuba; Yener, Görsev; de Graaf, Tom A.; Hanoglu, Lutfu; Yildirim, Ebru; Gunduz, Duygu Hunerli
Parkinson's disease (PD) is a movement disorder caused by degeneration in dopaminergic neurons. During the disease course, most of PD patients develop mild cognitive impairment (PDMCI) and dementia, especially affecting frontal executive functions. In this study, we tested the hypothesis that PDMCI patients may be characterized by abnormal neurophysiological oscillatory mechanisms coupling frontal and posterior cortical areas during cognitive information processing. To test this hypothesis, event-related EEG oscillations (EROs) during counting visual target (rare) stimuli in an oddball task were recorded in healthy controls (HC; N = 51), cognitively unimpaired PD patients (N = 48), and PDMCI patients (N = 53). Hilbert transform served to estimate instantaneous phase and amplitude of EROs from delta to gamma frequency bands, while modulation index computed ERO phase-amplitude coupling (PAC) at electrode pairs. As compared to the HC and PD groups, the PDMCI group was characterized by (1) more posterior topography of the delta-theta PAC and (2) reversed delta-low frequency alpha PAC direction, ie, posterior-to-anterior rather than anterior-to-posterior. These results suggest that during cognitive demands, PDMCI patients are characterized by abnormal neurophysiological oscillatory mechanisms mainly led by delta frequencies underpinning functional connectivity from frontal to parietal cortical areas.
Citation - WoS: 5
Citation - Scopus: 6
Adaptation of Quality of Life Measure for Limb Lymphedema-Arm in Turkish Women With Breast Cancer-Related Lymphedema
(Lippincott Williams & Wilkins, 2021) Karayurt, Ozgul; Deveci, Zeynep; Eyigor, Sibel; Inbat, Menekse Ozgur
Background Quality-of-life measures are needed for clinicians and researchers to identify quality of women's life with breast cancer-related lymphedema (BCRL). Objective To adapt Quality of Life Measure for Limb Lymphedema-Arm into Turkish (TR) and to test its validity and reliability. Methods This is a methodological and cross-sectional study and was conducted in the lymphedema outpatient clinic of a university hospital. The study included 109 women with BCRL. After linguistic validity of the scale was achieved, confirmatory factor analyses and known group validity were used to test its construct validity. Reliability of the scale was tested with Cronbach's alpha, item-total correlations, and Spearman-Brown coefficient. Results After linguistic validity was achieved, opinions requested from 5 experts specializing in lymphedema showed that item and content validity indexes of the scale were 1. Fit indexes of confirmatory factor analysis were as follows: chi(2)/df = 1.86, root mean square error of approximation = 0.089, standardized root mean square residual = 0.09, and comparative fit index = 0.81. Known group validity analysis showed a significant difference in the mean scores for the subscales of Quality of Life Measure for Limb Lymphedema-Arm-TR, symptom, function, and body image/appearance in terms of lymphedema stages (P < .05). The internal reliability coefficients for the subscales ranged from 0.78 and 0.86. The item-total correlation coefficients ranged between 0.36 and 0.73. Conclusion Quality of Life Measure for Limb Lymphedema-Arm-TR was found to be valid and reliable in the TR population. It could be used in research to evaluate the quality of life in patients with BCRL. Implications for Practice The scale can be used to evaluate effectiveness of nursing interventions directed toward patients developing breast cancer-related lymphedema in clinical settings and studies.
Citation - WoS: 7
Citation - Scopus: 9
Adults' Visual Cue Preferences and Wayfinding Abilities in Healthcare Centers
(Sage Publications Inc, 2023) Asli, Afsaneh Alizadeh; Moshfeghifar, Samaneh; Mousighichi, Pouya; Samimi, Paniz Mousavi
Objectives: Physical and visual elements that help people find their way around an environment are called visual cues (VCs). The current study aims to evaluate adults' wayfinding abilities (navigation, orientation, spatial anxiety, and distance estimation) and VC (navigational color coding) preferences in terms of color and position; additionally, investigates their differences in adults' life span phases (young adults, early middle-aged adults, and late middle-aged adults). Background: Wayfinding in complex environments such as healthcare centers has been challenging for most people. Although VCs are being used increasingly to facilitate wayfinding, considering people's preferences regarding VCs, especially navigational color coding, are neglected. Methods: Obtained data from a survey of 375 healthcare center visitors with textual and photo questionnaires were analyzed by descriptive statics and one-way analysis of variance. Results: Young adults preferred VCs with mixed colors and positioned in the middle of the floor, early middle-aged adults preferred warm color VCs in the middle of the wall, and late middle-aged adults preferred warm color VCs at the bottom of the wall. Additionally, the results demonstrated that with aging, navigation and distance estimation abilities deteriorate, and spatial anxiety increases. Conclusions: The outcomes of the present study increase our knowledge regarding the impact of adults' life span phases on their wayfinding abilities and VC preferences and offer suggestions for architects and healthcare center stakeholders to provide environments that improve adults' wayfinding.
Citation - WoS: 2
Citation - Scopus: 2
Age-Related Aspects of Sex Differences in Event-Related Brain Oscillatory Responses: a Turkish Study
(Mdpi, 2024) Yener, Görsev; Kıyı, İlayda; Düzenli-Öztürk, Seren; Yerlikaya, Deniz
Earlier research has suggested gender differences in event-related potentials/oscillations (ERPs/EROs). Yet, the alteration in event-related oscillations (EROs) in the delta and theta frequency bands have not been explored between genders across the three age groups of adulthood, i.e., 18-50, 51-65, and >65 years. Data from 155 healthy elderly participants who underwent a neurological examination, comprehensive neuropsychological assessment (including attention, memory, executive function, language, and visuospatial skills), and magnetic resonance imaging (MRI) from past studies were used. The delta and theta ERO powers across the age groups and between genders were compared and correlational analyses among the ERO power, age, and neuropsychological tests were performed. The results indicated that females displayed higher theta ERO responses than males in the frontal, central, and parietal regions but not in the occipital location between 18 and 50 years of adulthood. The declining theta power of EROs in women reached that of men after the age of 50 while the theta ERO power was more stable across the age groups in men. Our results imply that the cohorts must be recruited at specified age ranges across genders, and clinical trials using neurophysiological biomarkers as an intervention endpoint should take gender into account in the future.
Citation - WoS: 2
Citation - Scopus: 2
Aging Attenuated Theta Response During Multistable Perception
(Wiley, 2023) Küçük, Kurtulus Mert; Mathes, Birgit; Schmiedt-Fehr, Christina; Başar Eroğlu, Canan
Multistable stimuli are physically unchanging, but elicit spontaneous perceptual reversals between multiple internally generated perceptual alternatives. Perceptual reversal rates seem to decrease in older adults; however, there is no literature on the electrophysiological correlates of this performance decrease. Here, we aimed to identify age-related changes in theta activity that relate to decreased reversal rates of older adults. Electroencephalography (EEG) of young (n = 15) and older adults (n = 15) was recorded during presentation of stroboscopic alternative motion (SAM) and a control stimulus. Time-frequency amplitudes were extracted in 4-8 Hz via Morlet wavelet convolution. Older adults had lower SAM reversals as well as decreased accuracy, increased reaction time (RT) and increased RT variability in the control task. In older adults, reversal-related frontal theta response was diminished, yet parietal theta was intact. In the parietal area, the relationship between theta response and reversal rates was robust, but in the frontal area, was dependent on age-related variance. Result indicated that, in older adults, top-down facilitation of perceptual reversals was impaired. This appears to result in a predominantly bottom-up resolution of perceptual multistability. Age-related degradation of sensory areas in this bottom-up-driven resolution process might have slowed reversals. This study presents the first electrophysiological correlates of age-related impairment in multistable perceptual integration.
Citation - WoS: 36
Citation - Scopus: 39
Alteration of Mirnas in Small Neuron-Derived Extracellular Vesicles of Alzheimer's Disease Patients and the Effect of Extracellular Vesicles on Microglial Immune Responses
(Springernature, 2022) Durur, Devrim Yagmur; Tastan, Bora; Tufekci, Kemal Ugur; Olcum, Melis; Uzuner, Hamdiye; Karakulah, Gokhan; Yener, Görsev
Alzheimer's disease (AD) is one of the most severe neurodegenerative diseases observed in the elderly population. Although the hallmarks of AD have been identified, the methods for its definitive diagnosis and treatment are still lacking. Extracellular vesicles (EVs) have become a promising source for biomarkers since the identification of their content. EVs are released from multiple cell types and, when released from neurons, they pass from the brain to the blood with their cargo molecules. Hence, neuron-specific EV-resident microRNAs (miRNAs) are promising biomarkers for diagnosis of AD. This study aimed to identify altered miRNA content in small neuron-derived extracellular vesicles (sNDEVs) isolated from AD patients and healthy individuals. Furthermore, we examined the role of sNDEV-resident miRNAs in neuron-glia cellular interaction to understand their role in AD propagation. We identified 10 differentially expressed miRNAs in the sNDEVs of patients via next-generation sequencing and validated the most dysregulated miRNA, let-7e, with qRT-PCR. Let-7e was significantly increased in the sNDEVs of AD patients compared with those of healthy controls in a larger cohort. First, we evaluated the diagnostic utility of let-7e via ROC curve analysis, which revealed an AUC value of 0.9214. We found that IL-6 gene expression was increased in human microglia after treatment with sNDEVs of AD patients with a high amount of let-7e. Our study suggests that sNDEV-resident let-7e is a potential biomarker for AD diagnosis, and that AD patient-derived sNDEVs induce a neuroinflammatory response in microglia.
Citation - WoS: 25
Citation - Scopus: 29
Alterations in Levels of 8-Oxo '-deoxyguanosine and 8-Oxoguanine Dna Glycosylase 1 During a Current Episode and After Remission in Unipolar and Bipolar Depression
(Pergamon-Elsevier Science Ltd, 2020) Ceylan, Deniz; Yilmaz, Selda; Tuna, Gamze; Kant, Melis; Er, Ayse; Ildiz, Aysegul; Verim, Burcu
Introduction: Previous studies showed significant increases in DNA base damage markers and significant alterations in base excision repair enzymes in patients with unipolar and bipolar depression. We aimed to investigate changes in urine 8-Oxo-2'-deoxyguanosine (8-oxo-dG) and gene expression levels of 8-Oxoguanine DNA glycosylase 1 (OGG1) during a current depressive episode and after remission in bipolar and unipolar disorders. Methods: Twenty-four acutely depressed bipolar (BD), 33 unipolar depression (UD) patients and 61 healthy controls were included in the study. Clinical evaluations, blood and urine sampling were completed at baseline and at remission after eight weeks. The urine 8-oxo-dG levels were assessed by liquid chromatography tandem mass spectrometry and adjusted for urine creatinine levels. The gene expression levels of OGG1 were determined from cDNA extracted from blood samples, using real time-polymerase chain reaction. Results: At baseline, patients presented significantly higher levels of 8-oxo-dG (p = 0.008), and lower gene expression of OGG1 (p = 0.024) compared to controls. Levels of either 8-oxo-dG or OGG1 expression did not differ between BD and UD. In patients who remitted by the 8th week (n = 30), 8-oxo-dG decreased significantly (p = 0.001), and gene expression levels of OGG1 increased by 2.95 times compared to baseline levels (p = 0.001). All comparisons were adjusted for age, sex, smoking status and body mass index. Conclusion: Our results suggest that patients with bipolar and unipolar mood disorders present increased 8-oxo-dG and decreased gene expression levels of OGG1 in current depressive episodes, and that these changes might be reversed by the resolution of depressive symptoms. The causal relationship between DNA damage and repair requires further exploration.
Citation - WoS: 18
Citation - Scopus: 18
Altered Gamma and Theta Oscillations During Multistable Perception in Schizophrenia
(Elsevier, 2020) Rurup, Linda; Mathes, Birgit; Schmiedt-Fehr, Christina; Wienke, Annika Susann; Ozerdem, Aysegul; Brand, Andreas; Başar Eroğlu, Canan
Objective: Coherent object perception in patients with schizophrenia is known to be impaired. Oscillatory brain dynamics constitute a fundamental mechanism for the coordinated communication of neural circuits. Such dynamics have been proposed to reflect impaired spatio-temporal integration of sensory and cognitive processes during object perception in schizophrenia. Method: EEG recordings of patients with schizophrenia (n = 23) and control participants (n = 23) were examined. Presented were either an ambiguous (multistable) stimulus, endogenously inducing switching between two perceptual alternatives, or a slightly modified unambiguous control stimulus, during which perceptual reversals were triggered by a minor change in the stimulus configuration. Event-related amplitude modulation induced by perceptual reversals was analyzed for theta (3-8 Hz) and gamma band oscillations (28-48 Hz). Results: Patients displayed increased reaction times and more errors when indicating unambiguous reversals. The patients ' amplitude enhancement of theta oscillations was diminished in both task conditions. During the control task were gamma amplitudes larger in patients than in healthy participants. Conclusion: The results indicate that impairments in generating coherent percepts are reflected in alterations of multiple frequency bands and time windows. Changes in gamma band oscillations may reflect the patients' impairments in perceptuo-cognitive integration processes. Diminished theta amplitude modulation in patients further emphasize diminished top-down cognitive control during perceptual reversals. Significance: This study provides insight into how theta and gamma oscillations underlie changes in object perception, and thereby possibly the generation of core symptoms, in schizophrenia. This paper is dedicated to Prof. Dr. Erol Basar, a pioneer in research on oscillatory braindynamics. He was tireless in his effort to understand brain functions and integratedphilosophy, physics, biology and psychology in his research. His vision on how informationis coded in brain networks inspired many researchers in the last 40 years. With him, we not only lose an exceptional researcher, but also a supportive academic teacher and mentor with a persistent, prolific enthusiasm for international and collaborative projects.
Citation - WoS: 1
Citation - Scopus: 3
Analysis of the Highest Altmetrics-Scored Articles in Emergency Medicine Journals
(Westjem, 2025) Bayram, Basak; Cetin, Murot; Limon, Onder; Long, Brit; Gottlieb, Michael
Introduction: Alternative metrics (altmetrics) have emerged as invaluable tools for assessing the influence of scholarly articles. In this study we aimed to evaluate correlations between Altmetric Attention Scores (AAS), and sources and actual citations in articles displaying the highest AAS within emergency medicine (EM) journals. Methods: We conducted an analysis of EM journals listed in the Science Citation Index Expanded (SCIE) using the Altmetric Explorer tool. We analyzed the journals that received the highest number of mentions, the sources of AAS, the regions most frequently mentioned, and the geographical distribution of mentions. In the subsequent stage of our analysis, we conducted an examination of the 200 top- ranked articles that had received high AAS and were published in SCIE EM journals from January 1, 2013-January 1, 2023. We sought to determine the correlations between the AAS and the citation counts of articles on Google Scholar and the Web of Science (WOS). Results: Of 40,840 research outputs evaluated, there were 510,047 shares across multiple platforms. The AAS were present for 36,719 articles (89.9%), while 10.1% had no score. In the review of the top 200 articles with the highest AAS, the median score was 382.5 (interquartile range 301.3-510.8). Of the research output evaluated, 38% were observational studies, 13% case reports, and 13% reviews/metaanalyses. The most common research topics were emergency department (ED) management and COVID-19. There was no correlation between AAS and WOS citation numbers (r(s) = -0.041, P = 0.563, 95% confidence interval [CI] -0.175-0.087). There was a weak correlation identified between WOS citations and mentions on X, and a moderate correlation observed for WOS citations and blog mentions (r(s) = 0.330, P < .001, 95% CI 0.174 to 0.458; r(s)(2) = 0.109, and r(s) = 0.452, P < .001, 95% CI 0.320-0.566; and r(s)(2) = 0.204, respectively). However, we found a strong positive correlation between WOS citations and the number of Mendeley readers (r(s) = 0.873, P < .001, 95% CI 0.82-0.911, r(s)(2) = 0.762). Conclusion: While most articles in EM journals received an AAS, we found no correlation with traditional citation metrics. However, Mendeley readership numbers showed a strong positive correlation with citation counts, suggesting that academic platform engagement may better predict scholarly impact.
Citation - WoS: 2
Citation - Scopus: 1
Anthropometric and Demographic Properties Affect Balance in Healthy Adults: an Observational Study
(Edizioni Minerva Medica, 2021) Kurt, Merve; Tatlici, Ezgi; Simsek, Tulay Tarsuslu
BACKGROUND: Anthropometric and demographic properties may affect balance, but there is no consensus on this subject; so, there is a need for studies that explore it. This study aimed to assess the relationship between balance and anthropometric as well as demographic properties; and to determine the effect of anthropometric and demographic properties on balance in healthy adults. METHODS: Sixty healthy adults were included in this study. The ages of the participants were questioned; height, body weight, Body Mass Index, head circumference, upper extremity, lower extremity, and foot length were evaluated. and shoe numbers were recorded. Balance assessments were performed with the Balance Master System device. RESULTS: The mean age of the participants was 23.50 +/- 1.97 years. The balance developed with age (P<0.05), while there was a negative correlation between height and balance (P<0.05). Weight gain affected balance negatively (P<0.05). The increase in head circumference, extremity, and foot length was associated with a deterioration in balance (P<0.05). CONCLUSIONS: The results of the current study were showed that anthropometric and demographic properties affect balance. The increase in some of the anthropometric and demographic properties including height. weight. head circumference, extremity, and foot length harms the balance. During balance assessments, anthropometric and demographic characteristics should be considered as a factor that affects balance.
Citation - WoS: 11
Citation - Scopus: 13
Antibody separation using lectin modified poly(HEMA-EDMA) hydrogel membranes
(Taylor & Francis Ltd, 2018) Demir, Esra Feyzioglu; Kuru, Cansu Ilke; Uygun, Murat; Uygun, Deniz Aktas; Akgol, Sinan
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10.85 mol/g and 3.52 mg/g, respectively. Optimum conditions for IgG adsorption such as adsorption capacity, pH and reusability profile of HMs were judiciously characterized. Maximum IgG adsorption capacity of hydrogel membrane was found to be as 26.81 mg/g. Adsorbed IgG was eluted successfully by using 2.0 M of NaCl solution. Reusability profiles of hydrogel membrane in five adsorption-desorption cycles revealed that there was no significant decrease in IgG adsorption capacity at the end of the 5th reuse. The hydrogel membranes reported here hold considerable promise as an effective sorbent system for IgG adsorption with good stability and efficient repeated usage.
Citation - WoS: 2
Citation - Scopus: 4
Anxiety, Depression, Stress, and Self-Esteem in Turkish Parents of Children With Microtia
(Sage Publications Inc, 2023) Turhan Damar, Hale; Öğce, Filiz
Objective To describe factors affecting anxiety, depression, stress, and self-esteem in parents of children with microtia. Design Cross-sectional correlational study. Participants Parents (N = 117) of children with microtia were recruited nationally through a Turkish craniofacial non-governmental organization's social media. Main Outcome Measures Demographics, parental report of microtia experiences and concerns, the Depression Anxiety Stress Scale, and the Rosenberg Self-Esteem Scale. Results The mean parental age was 35.61 & PLUSMN; 5.96 years and 74.4% were female. The mean age of their children was 6.08 & PLUSMN; 4.22 years, 69.2% were male, 93.8% had unilateral microtia, and 14.5% had ear reconstruction. Some parents had low self-esteem (24.8%) and were in the severe range for depression (30.7%), anxiety (25.6%), and stress (21.4%). Depression (M = 7.43, SD = 5.35) was associated with worry about child's future (& beta; = 0.25, P = .013), microtia information given around birth (& beta; = -0.20, P = .024), and child no ear surgery (& beta; = -0.23, P = .008), while stress (M = 8.21, SD = 5.37) was associated with worry about the child's future (& beta; = 0.28, P = .008). Parental self-esteem (M = 29.59, SD = 5.10) was related to child having ear surgery (& beta; = 0.19, P = .047) and information about microtia provided around birth (& beta; = 0.22, P = .018). There were no significant associations with Anxiety (M = 6.04, SD = 4.82) identified by multiple regression. Conclusions While most parents were in the average to moderate range for clinical concerns, a fifth to a third of participants were in the severe range for depression, anxiety, and stress and a quarter of participants for low self-esteem. Informing families about the microtia treatment process, having the child have surgery, and interventions for reducing their future concerns may provide psychological relief for them.
Application of Various Microalgal Species for Lipid Production: Biotechnological and Engineering Aspects
(Springer Heidelberg, 2026) Habashy, Mahmoud M.; Li, Lu; Angulo-Mosquera, Lina S.; Bayar, Busra; Abubackar, Haris Nalakath; Keskin, Tugba; Rene, Eldon R.
Lipids derived from algal biomass are important constituents of biofuels, nutraceuticals, cosmeceuticals, and animal feed, inter alia. This necessitates the identification and large-scale production of microalgal species that can serve as the biomass based raw material for the above-mentioned categories of bio-products. In this vein, this review sifts through the literature and describes the most promising microalgal species that synthesize lipids and, when subjected to specific conditions, show enhanced lipid production. Currently, Chlorella sp., Cyclotella sp., Neochloris oleoabundans, and Isochrysis galbana are the species with the highest lipid contents. The review mentions and discusses various bioreactor configurations that can be used for large-scale culturing of these microalgae in a comparative aspect. Various configurations of photobioreactors are suitable for high biomass and lipid productivity. Further, prominent strategies of lipid extraction from microalgae have been elaborated, from conventional techniques to the latest ones, comparing and contrasting their advantages and disadvantages. While solvent-based extractions may have their advantages, it would be prudent to explore more eco-friendly techniques for scale-up. Lastly, the review gives a comprehensive account of the biorefinery approach to culturing microalgae, emphasising the assessment of their economic performance using different software and models, such as the techno-economic assessment model. The application of tools such as multi-criteria decision analysis that assess energy technology could enable better optimization. Microalgae have the potential to be used as a renewable source of fuel and feed; therefore, it is incumbent on the scientific community to significantly reduce production costs while ensuring sustainability.
Citation - WoS: 1
Citation - Scopus: 1
An Artificial Intelligence Model for Lhermitte's Sign in Patients With Pediatric-Onset Multiple Sclerosis: a Follow-Up Study
(Wroclaw Medical Univ, 2025) Uysal, Hasan A.; Poyraz, Turan; Gulluoglu, Halil; Idiman, Fethi; Idiman, Egemen
Background. Lhermitte's sign (LS) is an important clinical marker for patients with multiple sclerosis (MS). Research on pediatric-onset MS (POMS) and LS is limited. To date, there has been no research conducted on the clinical and artificial intelligence (AI)-based radiological correlation of LS. Objectives. This follow-up study aims to investigate the relationship between LS and clinical findings according to AI-based radiological characteristics of patients with POMS. Materials and methods. Basic descriptive statistics of patients with POMS according to sociodemographic, clinical and radiological findings were collected. Variables were evaluated at a 95% confidence level (95% CI), and a value of p < 0.05 was accepted as statistically significant. The LS in patients with MS was classified according to its presence in the past and at the time of the study screening: group A: absent; group B: positive in the past but absent at screening; group C: present both in the past and at the screening; group D: absent in the past but present at the screening. In addition, patients were grouped according to the duration of their MS, with the following classifications: <10 years and at least 10 years. Results. A total of 1,298 records were identified in the database search. Ninety-two patients who met the inclusion criteria were included in the study. The frequency of upper cervical lesions (C1-4 vertebral segmental levels) was higher in group B and C than in group A (p = 0.017). Among patients with an MS duration of 10-years, C1-4 lesions were least frequent in group A. Conclusions. Spinal imaging with AI-based programs can be used at least as much as brain magnetic resonance imaging (MRI) for early diagnosis, prognosis and treatment response. We have for the first time investigated LS in a large sample of patients with POMS. It is, however, recommended to conduct further multicenter studies to more specifically identify LS in patients with POMS.
Aso Visual Abstract: Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the Neosentiturk-Trials Mf18-02/18-03
(Springer, 2025) Cabioglu, N.; Karanlik, H.; Igci, A.; Muslumanoglu, M.; Gulcelik, M.A.; Uras, C.; Ozmen, V.
Citation - WoS: 2
Citation - Scopus: 3
Assessing the Effectiveness of Acs Surgical Risk Calculator Versus P-Possum in Predicting Mortality and Morbidity for Major Hepatobiliary Surgery: an Observational Study
(Lippincott williams & wilkins, 2024) Karabulut, Ali; Umman, Veysel; Oral, Güneş; Erginoz, Ergin; Çarkman, Mehmet Sinan
Risk assessment is difficult yet would provide valuable data for both the surgeons and the patients in major hepatobiliary surgeries. An ideal risk calculator should improve workflow through efficient, timely, and accurate risk stratification. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) surgical risk calculator (SRC) and Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (P-POSSUM) are surgical risk stratification tools used to assess postoperative morbidity. In this study, preoperative data from 300 patients undergoing major hepatobiliary surgeries performed at a single tertiary university hospital were retrospectively collected from electronic patient records and entered into the ACS-SRC and P-POSSUM systems, and the resulting risk scores were calculated and recorded accordingly. The ACS-NSQIP-M1 (C-statistics = 0.725) and M2 (C-statistics = 0.791) models showed better morbidity discrimination ability than P-POSSUM-M1 (C-statistics = 0.672) model. The P-POSSUM-M2 (C-statistics = 0.806) model showed better differentiation success in morbidity than other models. The ACS-NSQIP-M1 (C-statistics = 0.888) and M2 (C-statistics = 0.956) models showed better mortality discrimination than P-POSSUM-M1 (C-statistics = 0.776) model. The P-POSSUM-M2 (C-statistics = 0.948) model showed better mortality differentiation success than the ACS-NSQIP-M1 and P-POSSUM-M1 models. The use of ACS-SRC and P-POSSUM calculators for major hepatobiliary surgeries offers quantitative data to assess risks for both the surgeon and the patient. Integrating these calculators into preoperative evaluation practices can enhance decision-making processes for patients. The results of the statistical analyses indicated that the P-POSSUM-M2 model for morbidity and the ACS-NSQIP-M2 model for mortality exhibited superior overall performance.
Citation - WoS: 5
Citation - Scopus: 4
Assessment of Neutrophil/Lymphocyte Ratio and Mean Platelet Volume Values in Patients With Diabetes Mellitus Diagnosis: a Case-Control Study
(Lippincott Williams and Wilkins, 2024) Aygün, K.; Asma, Sakalli, A.; Küçükerdem, H.S.; Aygün, O.; Gökdemir, Ö.
Diabetes mellitus, fundamentally characterized by hyperglycemia, leads to significant metabolic disturbances. Type 2 diabetes mellitus is a chronic, inflammatory, preventable metabolic disease that is a significant health issue globally. The neutrophil-to-lymphocyte ratio (NLR) is an essential marker of systemic inflammation. We aimed to reveal the relationship between long-term glucose control and NLR, mean platelet volume (MPV), and red blood cell width in patients with type 2 diabetes. This was a retrospective case-control study. A total of 3532 applications in 2 years time were identified. Age, gender, medical history, white blood cell (WBC), hemoglobin, mean corpuscular volume (MCV), MPV, red blood cell width, NLR, hematocrit, platelet, C-reactive protein, Haemoglobin A1C data of the patients were analyzed. 1790 patients were included. A significant positive correlation was found between HbA1c and age, white blood cell, hematocrit, MCV, red blood cell width, NLR, and CRP. A statistically significant negative correlation was found between HbA1c and MCV. The results showed statistically significant differences between NLR, MPV, WBC, MCV, age, and HbA1c levels. Increased HbA1c levels are usually associated with an increase in these parameters. This is important for determining the risk of complications and protecting target organs in diabetic patients. A significant decrease in MCV levels was found as HbA1c levels increased. This suggests that evaluating red blood cells in routine controls of diabetic patients may indicate glycemic control. These findings may be valuable in early diagnosis of complications. Copyright © 2024 the Author(s).

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