PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/2

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Citation - WoS: 94
Citation - Scopus: 103
Affective Interpersonal Touch in Close Relationships: a Cross-Cultural Perspective
(Sage Publications Inc, 2021) Sorokowska, Agnieszka; Saluja, Supreet; Sorokowski, Piotr; Frackowiak, Tomasz; Karwowski, Maciej; Aavik, Toivo; Akello, Grace; Can, Seda
Interpersonal touch behavior differs across cultures, yet no study to date has systematically tested for cultural variation in affective touch, nor examined the factors that might account for this variability. Here, over 14,000 individuals from 45 countries were asked whether they embraced, stroked, kissed, or hugged their partner, friends, and youngest child during the week preceding the study. We then examined a range of hypothesized individual-level factors (sex, age, parasitic history, conservatism, religiosity, and preferred interpersonal distance) and cultural-level factors (regional temperature, parasite stress, regional conservatism, collectivism, and religiosity) in predicting these affective-touching behaviors. Our results indicate that affective touch was most prevalent in relationships with partners and children, and its diversity was relatively higher in warmer, less conservative, and religious countries, and among younger, female, and liberal people. This research allows for a broad and integrated view of the bases of cross-cultural variability in affective touch.
Citation - WoS: 6
Citation - Scopus: 6
Agreement Between Tele-Assessment and Face-To Assessment of 30-S Sit-To Test in Patients With Type 2 Diabetes Mellitus
(Springer London Ltd, 2023) Aktan, Ridvan; Yilmaz, Hayriye; Demir, Ismail; Ozalevli, Sevgi
Background The globalization of healthcare systems, and the aim to lower healthcare costs have all contributed to the growth of telehealth technology in recent years. However, before these systems are put into use, their efficacy should be verified. To the best of our knowledge, this is the first study focusing on the evaluation of functional exercise capacity using the 30-s sit-to-stand (30-s STS) test as a tele-assessment method in patients with type 2 diabetes mellitus (T2DM). Aims The purpose of the study is to investigate the level of agreement between tele-assessment and face-to-face assessment of 30-s STS test in patients with T2DM. Methods Fifty participants performed two times 30-s STS tests separated by 1 h: a face-to-face and an Internet-connected video call examination (tele-assessment). Two physiotherapists conduct these evaluations; each was blinded to the other. The order of the evaluations was designated at random for each participant and physiotherapist. Results There was a good level of agreement between tele-assessment and face-to-face assessment of the 30-s STS test (mean differences = 0.20 +/- 0.88, limits of agreement =1.93 to - 1.53). Excellent interrater reliability was found for scores of the 30-s STS test [ICC = 0.93 (95% CI: 0.88; 0.96)]. In addition, all before and after test parameters show that there was a very good interrater reliability (rho >= 0.75). Conclusions This study shows a good level of agreement between tele-assessment and face-to-face assessment of the 30-s STS test. Our study's findings indicate that tele-assessment is a potential application to determine the level of physical capacity remotely in patients with T2DM.
Citation - WoS: 1
Citation - Scopus: 1
Alterations of Store-Operated Calcium Entry and Cyclopiazonic Acid-Induced Endothelium-Derived Relaxations in Aging Rat Thoracic Aorta
(Akademiai Kiado Zrt, 2016) Erac, Y.; Selli, C.; Tosun, Metiner
The purpose of our study was to investigate whether endothelium-derived relaxations induced by store depletion are altered in aging rat thoracic aorta. Vascular responses were measured in aortic segments isolated from young (2-4 month) and old (20-24 month) male Sprague-Dawley rats. In phenylephrine-contracted intact tissues, receptor-mediated and receptor-independent endothelium-derived relaxations were induced by acetylcholine (ACh) and sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) blocker cyclopiazonic acid (CPA), respectively. In addition, CPA-induced changes in intracellular calcium levels were monitored in fura-2-loaded endothelium-denuded tissues. Real-time quantitative reverse transcription polymerase chain reaction and western blot analysis were performed to determine the transient receptor potential canonical (TRPC) 4 mRNA and protein levels. Endothelial TRPC4 mRNA levels were apparently decreased in aging rats. Immunoblot analysis showed that TRPC4 protein levels significantly decreased in intact aorta from 20- to 24-month-old rats compared to that from 2- to 4-month-old rats. ACh- and CPA-induced endothelium-dependent relaxations decreased in old rat aorta without any change in direct vasodilation induced by sodium nitroprusside. Store-operated Ca2+ entry (SOCE) induced by CPA was significantly decreased, whereas sarcoplasmic reticulum Ca2+ release was unaffected in endothelium-denuded aging rat aorta. In conclusion, TRPC4 downregulation could be associated with decreased endothelium-dependent vasorelaxations. As endothelial nitric oxide synthase is activated by SOCE-induced caveolar internalization, tracking the expression levels of SERCA, ion channels, and/or associated proteins involved in SOCE would lead to the development of novel therapeutics for age-related vasospastic disorders with dysfunctional endothelium.
Citation - WoS: 18
Citation - Scopus: 18
Altered Gamma and Theta Oscillations During Multistable Perception in Schizophrenia
(Elsevier, 2020) Rurup, Linda; Mathes, Birgit; Schmiedt-Fehr, Christina; Wienke, Annika Susann; Ozerdem, Aysegul; Brand, Andreas; Başar Eroğlu, Canan
Objective: Coherent object perception in patients with schizophrenia is known to be impaired. Oscillatory brain dynamics constitute a fundamental mechanism for the coordinated communication of neural circuits. Such dynamics have been proposed to reflect impaired spatio-temporal integration of sensory and cognitive processes during object perception in schizophrenia. Method: EEG recordings of patients with schizophrenia (n = 23) and control participants (n = 23) were examined. Presented were either an ambiguous (multistable) stimulus, endogenously inducing switching between two perceptual alternatives, or a slightly modified unambiguous control stimulus, during which perceptual reversals were triggered by a minor change in the stimulus configuration. Event-related amplitude modulation induced by perceptual reversals was analyzed for theta (3-8 Hz) and gamma band oscillations (28-48 Hz). Results: Patients displayed increased reaction times and more errors when indicating unambiguous reversals. The patients ' amplitude enhancement of theta oscillations was diminished in both task conditions. During the control task were gamma amplitudes larger in patients than in healthy participants. Conclusion: The results indicate that impairments in generating coherent percepts are reflected in alterations of multiple frequency bands and time windows. Changes in gamma band oscillations may reflect the patients' impairments in perceptuo-cognitive integration processes. Diminished theta amplitude modulation in patients further emphasize diminished top-down cognitive control during perceptual reversals. Significance: This study provides insight into how theta and gamma oscillations underlie changes in object perception, and thereby possibly the generation of core symptoms, in schizophrenia. This paper is dedicated to Prof. Dr. Erol Basar, a pioneer in research on oscillatory braindynamics. He was tireless in his effort to understand brain functions and integratedphilosophy, physics, biology and psychology in his research. His vision on how informationis coded in brain networks inspired many researchers in the last 40 years. With him, we not only lose an exceptional researcher, but also a supportive academic teacher and mentor with a persistent, prolific enthusiasm for international and collaborative projects.
An Analysis of Sample Size Calculations in Randomized Control Trials in Emergency Medicine
(W B Saunders Co-Elsevier Inc, 2025) Limon, Onder; Dogan, Nurettin Ozgur; Limon, Gulsum; Aksay, Ersin
Introduction: Sample size calculation enhances the quality of randomized clinical trials (RCTs) and, according to the CONSORT statement, should be reported and justified in published articles. This study aimed to evaluate the current quality of sample size calculation reporting in RCTs published in emergency medicine journals. Methods: The Web of Science (WoS) database was used for article retrieval. Journals indexed in WoS, published in English, categorized under "emergency medicine," and ranked in Q1 were included in the search. The sample size calculation method, power value, alpha value, effect size, and consideration of missing data were evaluated. Results: A total of 252 RCTs from 12 emergency medicine journals were included in the study. Only 30% of the articles explicitly stated compliance with CONSORT guidelines. Sample size calculations were reported in 84% of the articles. Alpha values were omitted in 12 % and beta (power) values in 8% of the articles. Effect sizes were not reported in 90 % of the studies. Notably, 11 % of the articles claiming CONSORT compliance did not include a sample size analysis. In the logistic regression analysis, none of the variables showed a statistically significant association with the presence of sample size analysis. Conclusion: Although emergency medicine journals show relatively better adherence to sample size calculation reporting compared to some other disciplines, their overall performance remains suboptimal. The findings highlight ongoing and significant deficiencies in the quality of RCT reporting, indicating that even leading journals in the field fall short of fully meeting recommended standards. (c) 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Citation - WoS: 1
Citation - Scopus: 3
Analysis of the Highest Altmetrics-Scored Articles in Emergency Medicine Journals
(Westjem, 2025) Bayram, Basak; Cetin, Murot; Limon, Onder; Long, Brit; Gottlieb, Michael
Introduction: Alternative metrics (altmetrics) have emerged as invaluable tools for assessing the influence of scholarly articles. In this study we aimed to evaluate correlations between Altmetric Attention Scores (AAS), and sources and actual citations in articles displaying the highest AAS within emergency medicine (EM) journals. Methods: We conducted an analysis of EM journals listed in the Science Citation Index Expanded (SCIE) using the Altmetric Explorer tool. We analyzed the journals that received the highest number of mentions, the sources of AAS, the regions most frequently mentioned, and the geographical distribution of mentions. In the subsequent stage of our analysis, we conducted an examination of the 200 top- ranked articles that had received high AAS and were published in SCIE EM journals from January 1, 2013-January 1, 2023. We sought to determine the correlations between the AAS and the citation counts of articles on Google Scholar and the Web of Science (WOS). Results: Of 40,840 research outputs evaluated, there were 510,047 shares across multiple platforms. The AAS were present for 36,719 articles (89.9%), while 10.1% had no score. In the review of the top 200 articles with the highest AAS, the median score was 382.5 (interquartile range 301.3-510.8). Of the research output evaluated, 38% were observational studies, 13% case reports, and 13% reviews/metaanalyses. The most common research topics were emergency department (ED) management and COVID-19. There was no correlation between AAS and WOS citation numbers (r(s) = -0.041, P = 0.563, 95% confidence interval [CI] -0.175-0.087). There was a weak correlation identified between WOS citations and mentions on X, and a moderate correlation observed for WOS citations and blog mentions (r(s) = 0.330, P < .001, 95% CI 0.174 to 0.458; r(s)(2) = 0.109, and r(s) = 0.452, P < .001, 95% CI 0.320-0.566; and r(s)(2) = 0.204, respectively). However, we found a strong positive correlation between WOS citations and the number of Mendeley readers (r(s) = 0.873, P < .001, 95% CI 0.82-0.911, r(s)(2) = 0.762). Conclusion: While most articles in EM journals received an AAS, we found no correlation with traditional citation metrics. However, Mendeley readership numbers showed a strong positive correlation with citation counts, suggesting that academic platform engagement may better predict scholarly impact.
Citation - WoS: 2
Citation - Scopus: 2
Analysis of the Quadratus Lumborum Muscle Activity on Leg Length Discrepancy: a Randomized Controlled Trial
(Ios Press, 2022) Eryigit, Sevim; Al Kafee, Abdullah; Akan, Aydin
BACKGROUND: Quadratus lumborum (QL) discrete region extensions might change depending on whether leg length discrepancy (LLD) individually has any extra erector spinae action in the lumbar spine, which can result in serious injury to the lower extremities and lumbar vertebrae. OBJECTIVE: This study aims to investigate the effect of QL muscle activity on LLD by using electromyography (EMG) signals. METHODS: The study employed a randomized controlled design. A total of 100 right-handed volunteers were included in this study. All participants were assessed manually by tape measurement for LLD. EMG signals were recorded during the resting and maximal isometric contraction positions to determine QL muscle activity. The power spectral density (PSD) methods were applied to compute EMG signals. RESULTS: In maximal isometric contraction position, comparing the short right LLD (Right side = 0.00064 +/- 0.00001, Left side = 0.00033 +/- 0.0006) and short left LLD (Right side = 0.00001 +/- 0.00008, Left side = 0.00017 +/- 0.0001), it was found that the short right LLD group had significantly increased PSD of EMG values. In resting position, the short right LLD (Right side = 0.0002 +/- 0.0073, Left side = -0.00016 +/- 0.0065) had significantly increased PSD of EMG compared to the short left LLD (Right side = 0.00004 +/- 0.0003, Left side = 0.0001 +/- 0.0008) values of the QL muscle activity. The results of both groups were also statistically significant (p < 0.05). CONCLUSIONS: The present study showed that it is possible to determine effective experimental interventions for functional LLD using EMG signal analysis of QL muscle activity on an asymptomatic normal population.
Citation - WoS: 40
Citation - Scopus: 46
Animals as Mobile Biological Sensors for Forest Fire Detection
(Mdpi, 2007) Sahin, Yasar Guneri
This paper proposes a mobile biological sensor system that can assist in early detection of forest fires one of the most dreaded natural disasters on the earth. The main idea presented in this paper is to utilize animals with sensors as Mobile Biological Sensors (MBS). The devices used in this system are animals which are native animals living in forests, sensors (thermo and radiation sensors with GPS features) that measure the temperature and transmit the location of the MBS, access points for wireless communication and a central computer system which classifies of animal actions. The system offers two different methods, firstly: access points continuously receive data about animals' location using GPS at certain time intervals and the gathered data is then classified and checked to see if there is a sudden movement (panic) of the animal groups: this method is called animal behavior classification (ABC). The second method can be defined as thermal detection (TD): the access points get the temperature values from the MBS devices and send the data to a central computer to check for instant changes in the temperatures. This system may be used for many purposes other than fire detection, namely animal tracking, poaching prevention and detecting instantaneous animal death.
Citation - WoS: 11
Citation - Scopus: 13
Antibody separation using lectin modified poly(HEMA-EDMA) hydrogel membranes
(Taylor & Francis Ltd, 2018) Demir, Esra Feyzioglu; Kuru, Cansu Ilke; Uygun, Murat; Uygun, Deniz Aktas; Akgol, Sinan
Herein we describe the synthesis of Concanavalin A-poly(2-hydroxyethyl methacrylate-ethylene dimethacrylate) hydrogel membranes (via photopolymerization technique) for antibody separation from aqueous solutions. Different characterization techniques including Scanning Electron Microscopy, Fourier Transform Infrared Spectroscopy, Elemental Analysis and swelling tests revealed the highly rough morphology and spherical shape of the synthetized membranes. Attached amount of IMEO (salinization agent) onto polymeric structure and Con A binding capacity were found to be 10.85 mol/g and 3.52 mg/g, respectively. Optimum conditions for IgG adsorption such as adsorption capacity, pH and reusability profile of HMs were judiciously characterized. Maximum IgG adsorption capacity of hydrogel membrane was found to be as 26.81 mg/g. Adsorbed IgG was eluted successfully by using 2.0 M of NaCl solution. Reusability profiles of hydrogel membrane in five adsorption-desorption cycles revealed that there was no significant decrease in IgG adsorption capacity at the end of the 5th reuse. The hydrogel membranes reported here hold considerable promise as an effective sorbent system for IgG adsorption with good stability and efficient repeated usage.
Application of Various Microalgal Species for Lipid Production: Biotechnological and Engineering Aspects
(Springer Heidelberg, 2026) Habashy, Mahmoud M.; Li, Lu; Angulo-Mosquera, Lina S.; Bayar, Busra; Abubackar, Haris Nalakath; Keskin, Tugba; Rene, Eldon R.
Lipids derived from algal biomass are important constituents of biofuels, nutraceuticals, cosmeceuticals, and animal feed, inter alia. This necessitates the identification and large-scale production of microalgal species that can serve as the biomass based raw material for the above-mentioned categories of bio-products. In this vein, this review sifts through the literature and describes the most promising microalgal species that synthesize lipids and, when subjected to specific conditions, show enhanced lipid production. Currently, Chlorella sp., Cyclotella sp., Neochloris oleoabundans, and Isochrysis galbana are the species with the highest lipid contents. The review mentions and discusses various bioreactor configurations that can be used for large-scale culturing of these microalgae in a comparative aspect. Various configurations of photobioreactors are suitable for high biomass and lipid productivity. Further, prominent strategies of lipid extraction from microalgae have been elaborated, from conventional techniques to the latest ones, comparing and contrasting their advantages and disadvantages. While solvent-based extractions may have their advantages, it would be prudent to explore more eco-friendly techniques for scale-up. Lastly, the review gives a comprehensive account of the biorefinery approach to culturing microalgae, emphasising the assessment of their economic performance using different software and models, such as the techno-economic assessment model. The application of tools such as multi-criteria decision analysis that assess energy technology could enable better optimization. Microalgae have the potential to be used as a renewable source of fuel and feed; therefore, it is incumbent on the scientific community to significantly reduce production costs while ensuring sustainability.
Citation - WoS: 2
Citation - Scopus: 3
Assessing the Effectiveness of Acs Surgical Risk Calculator Versus P-Possum in Predicting Mortality and Morbidity for Major Hepatobiliary Surgery: an Observational Study
(Lippincott williams & wilkins, 2024) Karabulut, Ali; Umman, Veysel; Oral, Güneş; Erginoz, Ergin; Çarkman, Mehmet Sinan
Risk assessment is difficult yet would provide valuable data for both the surgeons and the patients in major hepatobiliary surgeries. An ideal risk calculator should improve workflow through efficient, timely, and accurate risk stratification. The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) surgical risk calculator (SRC) and Portsmouth Physiological and Operative Severity Score for the enUmeration of Mortality and Morbidity (P-POSSUM) are surgical risk stratification tools used to assess postoperative morbidity. In this study, preoperative data from 300 patients undergoing major hepatobiliary surgeries performed at a single tertiary university hospital were retrospectively collected from electronic patient records and entered into the ACS-SRC and P-POSSUM systems, and the resulting risk scores were calculated and recorded accordingly. The ACS-NSQIP-M1 (C-statistics = 0.725) and M2 (C-statistics = 0.791) models showed better morbidity discrimination ability than P-POSSUM-M1 (C-statistics = 0.672) model. The P-POSSUM-M2 (C-statistics = 0.806) model showed better differentiation success in morbidity than other models. The ACS-NSQIP-M1 (C-statistics = 0.888) and M2 (C-statistics = 0.956) models showed better mortality discrimination than P-POSSUM-M1 (C-statistics = 0.776) model. The P-POSSUM-M2 (C-statistics = 0.948) model showed better mortality differentiation success than the ACS-NSQIP-M1 and P-POSSUM-M1 models. The use of ACS-SRC and P-POSSUM calculators for major hepatobiliary surgeries offers quantitative data to assess risks for both the surgeon and the patient. Integrating these calculators into preoperative evaluation practices can enhance decision-making processes for patients. The results of the statistical analyses indicated that the P-POSSUM-M2 model for morbidity and the ACS-NSQIP-M2 model for mortality exhibited superior overall performance.
Citation - WoS: 5
Citation - Scopus: 4
Assessment of Neutrophil/Lymphocyte Ratio and Mean Platelet Volume Values in Patients With Diabetes Mellitus Diagnosis: a Case-Control Study
(Lippincott Williams and Wilkins, 2024) Aygün, K.; Asma, Sakalli, A.; Küçükerdem, H.S.; Aygün, O.; Gökdemir, Ö.
Diabetes mellitus, fundamentally characterized by hyperglycemia, leads to significant metabolic disturbances. Type 2 diabetes mellitus is a chronic, inflammatory, preventable metabolic disease that is a significant health issue globally. The neutrophil-to-lymphocyte ratio (NLR) is an essential marker of systemic inflammation. We aimed to reveal the relationship between long-term glucose control and NLR, mean platelet volume (MPV), and red blood cell width in patients with type 2 diabetes. This was a retrospective case-control study. A total of 3532 applications in 2 years time were identified. Age, gender, medical history, white blood cell (WBC), hemoglobin, mean corpuscular volume (MCV), MPV, red blood cell width, NLR, hematocrit, platelet, C-reactive protein, Haemoglobin A1C data of the patients were analyzed. 1790 patients were included. A significant positive correlation was found between HbA1c and age, white blood cell, hematocrit, MCV, red blood cell width, NLR, and CRP. A statistically significant negative correlation was found between HbA1c and MCV. The results showed statistically significant differences between NLR, MPV, WBC, MCV, age, and HbA1c levels. Increased HbA1c levels are usually associated with an increase in these parameters. This is important for determining the risk of complications and protecting target organs in diabetic patients. A significant decrease in MCV levels was found as HbA1c levels increased. This suggests that evaluating red blood cells in routine controls of diabetic patients may indicate glycemic control. These findings may be valuable in early diagnosis of complications. Copyright © 2024 the Author(s).
Citation - WoS: 1
Citation - Scopus: 1
Attitudes Toward Pre-Symptomatic Screening for Alzheimer's Dementia in Five European Countries: a Comparison of Family Members of People With Alzheimer's Dementia Versus Non-Family Members
(Frontiers Media Sa, 2023) Angelidou, Ioanna A.; Makri, Marina; Beyreuther, Konrad; Rovira, Merce Boada; Despoti, Akyllina; Engelborghs, Sebastiaan; Miguel, Andrea; Yener, Görsev; Yerlikaya, Deniz
Introduction: Pre-symptomatic screening is getting more attention in healthcare as it detects the risk for developing neurodegenerative diseases like Alzheimer's disease (AD), which is very useful for treatment or prevention. AD screening could play an important role in individuals with at least one affected first-degree relative, but also without family history. As the demand for screening is rising worldwide, it is important to consider possible cross-cultural differences in attitudes toward pre-symptomatic screening in order to tailor healthcare services to the needs of each country.Objective: This study aims to investigate the attitudes of family members and non-family members of people with dementia toward pre-symptomatic screening and explore possible differences in attitudes across five European countries (Belgium, Germany, Greece, Spain, Turkey) using translated versions of the Perceptions regarding pRE-symptomatic Alzheimer's Disease Screening questionnaire (PRE-ADS).Methods: The multicultural sample (N = 650) was recruited from samples that were previously used in validation studies of the translated PRE-ADS versions. The subscale Acceptability of Screening, consisting of five PRE-ADS items to specifically explore willingness to undergo screening, was created. Iota nternal consistency was measured, and structural validity was determined using Confirmatory Factor Analysis (CFA). Group comparisons were performed to investigate differences in attitudes toward pre-symptomatic AD screening regarding family history and country of origin using the PRE-ADS and the Acceptability of Screening mean scores.Results: Construct validity was acceptable for the PRE-ADS. Both the PRE-ADS (alpha = 0.76) and its subscale Acceptability of Screening (alpha = 0.90) had good internal consistency. Overall, 56.9% of the total sample expressed a positive intention toward pre-symptomatic AD screening. T-tests showed significantly higher mean scores of participants with an affected family member. An international comparison revealed differences in the Acceptability of Screening mean score across the five European countries. No cross-cultural differences were found for the PRE-ADS mean score after adjusting for confounding variables.Conclusion: The PRE-ADS and its subscale are reliable tools for assessing pre-symptomatic AD screening attitudes. Variations in the acceptability of screening seem to be linked to family history and cultural influences. Further research with larger samples is needed to explore underlying relationships.
Autoimmune Thyroiditis and Its Impact on the Clinical Course of Multiple Sclerosis: a Retrospective Cohort Study
(Elsevier Sci Ltd, 2025) Kaya, Ergi; Samadzade, Ulvi; Zengin, Ela Simay; Ozakbas, Serkan
Introduction: Autoimmune thyroiditis (AT) stands out as one of the most prevalent accompanying comorbidity of Multiple Sclerosis (MS). However, the specific impact of AT on the clinical course of MS is relatively unexplored. Objectives: The primary objective of this study is to determine the frequency of AT within an MS cohort and to assess its influence on the prognosis of MS. Method: We retrospectively detected those who had an AT diagnosis during their lifetime. Patients who had been diagnosed with AT before a diagnosis of MS or during the diagnosis process were analyzed for prognosis. (aMS) Demographic variables, baseline Expanded Disability Status Scale (EDSS) score and relapse number, disease- modifying treatment duration and type, the relapse number, new/expanding lesions in brain and spinal MRI in first five years, fifth-year EDSS and fifth year No Evidence of Disease Activitiy-3 results were collected. These variables were compared to people with MS who had similar baseline and demographic characteristics. (non-AT) Results: Fifty-seven people with MS (1.6 %) were diagnosed with AT, all of whom were female. Twenty-four of them were included in the prognosis analysis. There was no statistical difference between aMS and nonAT in diagnosis age, baseline relapse number and baseline EDSS score. (p > 0.05) There were no statistical differences in relapse number, MRI activity in five years, EDSS scores and NEDA-3 status in the fifth year. (P > 0.05) Conclusion: Comorbid AT is frequently seen in the MS population. It has a neutral effect on the MS course.
Citation - WoS: 64
Citation - Scopus: 76
Automated Patient-Specific Classification of Long-Term Electroencephalography
(Academic Press Inc Elsevier Science, 2014) Kiranyaz, Serkan; İnce, Türker; Zabihi, Morteza; Ince, Dilek
This paper presents a novel systematic approach for patient-specific classification of long-term Electroencephalography (EEG). The goal is to extract the seizure sections with a high accuracy to ease the Neurologist's burden of inspecting such long-term EEG data. We aim to achieve this using the minimum feedback from the Neurologist. To accomplish this, we use the majority of the state-of-the-art features proposed in this domain for evolving a collective network of binary classifiers (CNBC) using multi-dimensional particle swarm optimization (MD PSO). Multiple CNBCs are then used to form a CNBC ensemble (CNBC-E), which aggregates epileptic seizure frames from the classification map of each CNBC in order to maximize the sensitivity rate. Finally, a morphological filter forms the final epileptic segments while filtering out the outliers in the form of classification noise. The proposed system is fully generic, which does not require any a priori information about the patient such as the list of relevant EEG channels. The results of the classification experiments, which are performed over the benchmark CHB-MIT scalp long-term EEG database show that the proposed system can achieve all the aforementioned objectives and exhibits a significantly superior performance compared to several other state-of-the-art methods. Using a limited training dataset that is formed by less than 2 min of seizure and 24 min of non-seizure data on the average taken from the early 25% section of the EEG record of each patient, the proposed system establishes an average sensitivity rate above 89% along with an average specificity rate above 93% over the test set. (C) 2014 Elsevier Inc. All rights reserved.
Citation - WoS: 20
Citation - Scopus: 20
Awareness, Treatment, Control of Hypertension, and Associated Factors: Results From a Turkish National Study
(Taylor & Francis Inc, 2018) Dastan, Ilker; Erem, Ayşegül; Cetinkaya, Volkan
Objective: Despite the fact that hypertension (HT) can be diagnosed and easily treated, it is frequently not handled well throughout the world, and as a developing country in Turkey. The objective of this study was to assess the factors associated with the awareness, treatment, and control of HT in Turkey. Methods: Data came from Chronic Diseases and Risk Factors Survey, comprising a nationally representative sample of 12,971 individuals, conducted by the Turkish Ministry of Health in 2011. HT was defined as having systolic/diastolic blood pressure (BP) at least 140/90 mmHg, usage of HT medicines, or having a previous diagnosis. Awareness, treated, and controlled HT were determined by questionnaires/BP measurements. Stepwise multiple logistic regression analysis was used to estimate associated factors. Results: The prevalence of HT was found to be 24.8%. Awareness, treatment, and control rates were 65%, 59%, and 30%, respectively. The risk factors for lack of awareness or treatment of HT were male gender, young age, rural residency, lower education, being employed, sedentary lifestyle, and less physical activity for women, unhealthy dietary habits for men, and modifiable risk factors, including smoking and drinking for men. Increasing age, low education for women, marital status subgroups within gender ( being single for men and being married for women), smoking and alcohol use for men, and diseases such as diabetes and obesity were also correlated with poor control of HT. Conclusion: This study recognized associated risk factors that may guide policies and interventions to enhance awareness, treatment, and control of HT in Turkey.
A Bibliometric Analysis of Clinical Studies on Artificial Intelligence in Emergency Medicine
(Lippincott Williams & Wilkins, 2025) Limon, Ö.; Bayram, B.; Çetin, M.; Limon, G.; Dirican, N.
Background: Interest in artificial intelligence (AI) and machine learning (ML) has grown rapidly in recent years due to the success of modern algorithms across various domains. Emergency departments are fast-paced and resource-constrained environments where timely decision-making is critical. These characteristics make them ideal settings for the integration of AI technologies, which have shown potential to enhance diagnostic accuracy and optimize patient outcomes. This study aims to identify and characterize the scientific literature on AI and ML applications in emergency departments over the past decade. Methods: A comprehensive search was conducted in the Web of Science database on June 20, 2024. Articles published between 2015 and 2024 were considered. The search was performed using the keywords "artificial intelligence"or "machine learning"in all fields, limited to the "emergency medicine"category. The analysis of the articles included descriptive data on primary publication characteristics, such as the number of authors, citations, country of origin of the coauthors, and journal names. Bibliometric indicators were analyzed to identify publication trends and research themes, cluster analyses of keywords, and thematic maps. Results: A total of 321 articles were analyzed. The average number of citations per article was 10.04, and the annual growth rate was 37.87%. Most publications originated from the United States. Resuscitation, American Journal of Emergency Medicine, Injury-International Journal of the Care of the Injured, and Resuscitation Plus published 107 articles. In 2024, the trending topic of the articles was "health,"while "care"was the most popular in the last 10 years. The top 5 niche themes were "medical,""digital transformation,""education,""database,"and "emergency care systems."Conclusion: This bibliometric analysis highlights the growing role of AI in emergency medicine. The findings provide insight into current research directions and may help inform future investigations in this evolving field. © 2025 the Author(s).
Citation - WoS: 12
Biocompatibility of Vertically Aligned Multi-Walled Carbon Nanotube Scaffolds for Human Breast Cancer Cell Line Mda-Mb
(Springer Heidelberg, 2017) Akinoglu, E. M.; Ozbilgin, K.; Sonmez, P. Kilicaslan; Ozkut, M. M.; Giersig, M.; İnan, Sevinç; Gumustepe, E.
The aim of the current study was to determine whether the MWCNT-based scaffold has a suitable structure for cell growth and provides a biocompatible environment for human MDA-MB-231 cell lines. MWCNT-based nanostructured scaffolds were produced by plasma-enhanced chemical vapor deposition (PECVD) technique. MDA-MB-231 cells were seeded on MWCNTs-textured silicon scaffolds and on pristine silicon surfaces. After 1 week of culturing, the scaffolds were prepared for SEM analysis and immunocytochemical staining was performed for the two groups (MWCNT scaffold and pristine silicon surface), using MMP-2, MMP-9, PI3K, AKT and NF-kappa B primary antibodies. SEM analyses showed that the MDA-MB-231 cells better adhered to the MWCNT-based nanostructured scaffold than the pristine silicon surface. Immunohistochemical activity of the MDA-MB-231 cells on both materials has similar staining with anti-AKT MMP-2, MMP-9 and NF-kappa B primary antibodies. Therefore, the results of the present study suggest that the MWCNT-based scaffolds enhanced cell adhesion to the scaffold and exhibited more biomimetic properties and physiological adaptation with the potential to be used for in vitro metastasis studies of BrCa cell lines.
Citation - WoS: 29
Citation - Scopus: 37
Blind Ecg Restoration by Operational Cycle-Gans
(IEEE-Inst Electrical Electronics Engineers Inc, 2022) Kiranyaz, Serkan; Devecioglu, Ozer Can; İnce, Türker; Malik, Junaid; Chowdhury, Muhammad; Hamid, Tahir; Mazhar, Rashid
Objective: ECG recordings often suffer from a set of artifacts with varying types, severities, and durations, and this makes an accurate diagnosis by machines or medical doctors difficult and unreliable. Numerous studies have proposed ECG denoising; however, they naturally fail to restore the actual ECG signal corrupted with such artifacts due to their simple and naive noise model. In this pilot study, we propose a novel approach for blind ECG restoration using cycle-consistent generative adversarial networks (Cycle-GANs) where the quality of the signal can be improved to a clinical level ECG regardless of the type and severity of the artifacts corrupting the signal. Methods: To further boost the restoration performance, we propose 1D operational Cycle-GANs with the generative neuron model. Results: The proposed approach has been evaluated extensively using one of the largest benchmark ECG datasets from the China Physiological Signal Challenge (CPSC-2020) with more than one million beats. Besides the quantitative and qualitative evaluations, a group of cardiologists performed medical evaluations to validate the quality and usability of the restored ECG, especially for an accurate arrhythmia diagnosis. Significance: As a pioneer study in ECG restoration, the corrupted ECG signals can be restored to clinical level quality. Conclusion: By means of the proposed ECG restoration, the ECG diagnosis accuracy and performance can significantly improve.
Bound by Society: An Exploratory Study of Pet Attachment and Social Constraints in Pet Bereavement Among a Turkish Sample
(Routledge Journals, Taylor & Francis Ltd, 2025) Demirci, Oyku; Yuksel, Ozge; Meral, Yasemin
Pet owners often form deep emotional bonds with their animals, and the death of a pet can elicit grief responses similar to human loss. However, pet loss is often considered disenfranchized grief, socially unrecognized and unsupported. Guided by social-cognitive processing and attachment perspectives, this study examines how pet attachment, social constraints, and loss-related variables shape grief intensity. The study included 210 adults who lost a pet within the past year and completed measures of pet bereavement, attachment to pets, and social constraints. Attachment to the pet was the strongest predictor of grief severity, while social constraints also influenced grief, with those facing emotional inhibition experiencing greater distress. Loss-related factors such as euthanasia initially predicted grief, but their effect diminished once attachment and social constraints were considered. These findings emphasize the multifaceted nature of pet loss grief and the need for greater societal recognition and support for the bereaved pet owners.

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