TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4

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  • Article
    Echoes of the Past: Are E-Cigarettes the New "Light" Cigarettes
    (2026-01-29) Yıldız, E.; Kilinç, O.; Çuhadaroǧlu, Ç.
  • Article
    Turkish Thoracic Society Declaration on Peace and Health the Importance of Breathing in a World Without Ware
    (Galenos Publ House, 2026-01-30) Cetinkaya, Pelin Duru; Toreyin, Zehra Nur; Ozdemir, Hande Yuce; Yasin, Yesim; Kilinc, Oguz; Yorgancioglu, Arzu; Begic, Erencan; Bingöl, Züleyha; Erencan, Begiç; Kaya, Aslıhan Gürün; Demirdöğen, Ezgi
    War legitimizes the right to kill for its participants, equating victory with moral justification, however, this perceived legitimacy is largely Constructed on the deaths of civilians and other living beings. Medicine, by its very nature, is grounded in the principles of preserving ife, doing no harm, and adhering to scientific and ethical standards, and is therefore fundamentally opposed to the philosophy of war. Wars lead, directly and indirectly, to desaths, disability, displacement, poverty, and long-term public health disasters. Attacks on health Facilities, restrictions on access to food and water, environmental destruction, and air pollution disproportionately affect vulnerable Dopulations, particularly women and children. The psychological consequences of war often evolve into persistent neuropsychiatric conditions, including post-traumatic stress disorder, depression, and moral injury. Peace is not merely the absence of war, it is a prerequisite for health, environmental sustainability, and social well-being. The concept of positive peace strengthens health indicators hrough well-functioning institutions, equitable resource distribution, and the protection of human rights. Within this framework, health professionals and civil society organizations are critical actors in advocating for peace and in making human rights violations visible The Turkish Thoracic Society regards peace as an indispensable condition for public and respiratory health, affirms its opposition to all wars particularly the ongoing atrocities in Gaza-and reaffirms its commitment to sustained, health-based advocacy for peace,
  • Letter
    The Necessity of Bronchiectasis Registries - The Turkish Registry of Bronchiectasis
    (Galenos Publ House, 2026-01-20) Kizilirmak, Deniz; Martinez-Garcia, Miguel Angel; Cicek, Sedat; Coskun, Aysin Sakar; Kilinc, Oguz; Edis, Ebru Cakir
    Bronchiectasis demonstrates a significant discrepancy between its high prevalence and the limited evidence base. Patient registries, both national and international, are key to collecting comprehensive data. However, the cost-effectiveness of this approach remains a subject of ongoing debate.1 In the opinion of the authors of this editorial, despite the significant costs and effort involved in establishing such registries, they are justified—provided that certain key characteristics are met. The registry must be sufficiently comprehensive in capturing relevant variables to avoid missing critical data that could impede meaningful research, particularly in areas such as therapeutic interventions, comorbidities, microbiological findings, and prognostic factors.
  • Article
    Impact of Inspiratory Muscle Strength and Lung Function on Functional Exercise Capacity in Post-Myocardial Infarction Patients: A Cross-Sectional Study
    (Galenos Publishing House, 2025-09-18) Aktan, Rıdvan; Ozalevli, Sevgi; Dursun, Huseyin; Aktan, Özge Ocaker; Ocaker Aktan, Ozge
    OBJECTIVE: This study aims to investigate the contribution of lung function and respiratory muscle strength in predicting functional exercise capacity in post-myocardial infarction (MI) subjects. MATERIAL AND METHODS: This cross-sectional study included 56 stable post-MI subjects. Lung function was assessed using a digital spirometer, and respiratory muscle strength was measured using an intraoral pressure meter. The 6-minute walk distance (6MWD) was conducted to assess functional exercise capacity. Correlations and multiple regression analyses were performed to evaluate predictors of 6MWD, considering demographic factors, lung function, and respiratory muscle strength. The Bland-Altman plot was used to investigate the agreement between observed and predicted 6MWDs. RESULTS: Significant positive correlations were found between 6MWD and forced vital capacity (FVC)%predicted (r = 0.528, P = 0.022) and maximum inspiratory pressure (MIP)%predicted (r = 0.640, P = 0.022). Age (r = -0.350, P = 0.008) and body mass index (BMI) (r= -0.561, P < 0.001) were negatively correlated with 6MWD. The best regression model included MIP%predicted (β = 0.332, P = 0.002), BMI (β = -0.264, P = 0.012), being male (β = 0.262, P = 0.003), age (β = -0.210, P = 0.020), and FVC%predicted (β = 0.219, P = 0.026) as significant unique contributors. The final multiple linear regression model was significant [F (5, 50) = 19.08, P < 0.001] and explained 65.6% of the variance (R2 = 0.656) in the 6MWD. CONCLUSION: Lung function and respiratory muscle strength significantly contribute to functional exercise capacity in post-MI. This study emphasizes the importance of comprehensive respiratory function assessments in rehabilitation strategies to improve exercise capacity in patients with post-MI.
  • Letter
    Response to: Effectiveness of a Program to Raise Awareness About Pneumococcal Vaccination Among Physicians and Patients with Chronic Respiratory Diseases: A Multicenter Cohort Study
    (Galenos Publ House, 2025-06-03) Şimşek, Nurdan; Altın, Sedat; Sayiner, Abdullah; Yalnız, Enver; Karakurt, Zuhal; Kul, Seval; Uslu, Ozgur; Veske, Nurdan Simsek; Karakut, Zuhal; Oruc, Ozlem
  • Article
    İnfluenza A/B Virüs ve RSV Validasyon Standartlarının Dijital PCR ile Kantitasyonu
    (Ankara Microbiology Soc, 2025-07-26) Sayıner, Ayca Arzu; Bulgurcu, Alıhan
    Mikrobiyolojik tanı laboratuvarlarında kullanılacak tanı testleri için kantitatif standartların kullanıldığı yöntem doğrulama (verification) veya geçerli kılma (validation) çalışmaları gereklidir. Nükleik asit testlerinde sentetik nükleik asit veya plazmit yerine tam virüs içeren standartların kullanılması; ekstraksiyon, revers transkripsiyon ve amplifikasyonu içerecek şekilde tanı testinin tüm basamaklarının gerçek yaşam koşullarında değerlendirilmesini sağlar. Solunum yolu virüsleri için nükleik asit testlerine yönelik ticari kantitatif standart materyaller sınırlıdır. Bu çalışmada; influenza A virüs (infA), influenza B virüs (infB) ve respiratuvar sinsityal virüs (RSV) için dijital polimeraz zincir reaksiyonu [digital polymerase chain reaction (dPCR)] kullanılarak, kantitatif nükleik asit standartları geliştirilmesi amaçlanmıştır. Çalışmada; RSV, infA, infB RNA pozitif olduğu bilinen nazofarengeal sürüntü örneklerinin havuzlanmasıyla hazırlanan örneklerdeki viral nükleik asit miktarı, ticari primer/prob setleri (Qiagen, Almanya) kullanılarak dPCR (QIAcuity, Qiagen) yöntemiyle belirlenmiştir. Nükleik asit ekstraksiyonu, ticari bir kit (Xi’an Tianlong Science&Technology Co, Çin) kullanılarak yapılmıştır. dPCR yönteminin infA, infB ve RSV için analitik duyarlılık (LoD) ve kantitasyon alt sınırı (LoQ), çalışma içi ve çalışmalar arası tekrarlanabilirliği ve doğrusallığı belirlenmiştir. dPCR ile çalışılan örnekler, kantitatif revers transkripsiyon gerçek zamanlı [quantitative reverse transcription realtime (qrRT)] PCR (qRT-PCR) ile de çalışılarak Ct değerleri belirlenmiştir. Ct değerleri ile dPCR-kantitasyon sonuçları arasındaki ilişki lineer regresyon ile değerlendirilmiştir. İstatistiksel analiz GraphPad Prism 10.4.0 (GraphPad, ABD) ve Excel Analysis ToolPak kullanılarak yapılmıştır. İnfA, infB ve RSV için dPCR yönteminin LoD değerleri sırasıyla 93.75, 15.59 ve 26.23 kopya/mL olarak belirlenmiştir. dPCR yönteminin çalışma içi tekrarlanabilirliği (varyasyon katsayısı, %CV), düşük viral yükü olan örneklerde daha yüksek olmak üzere 0.06-7.97 arası saptanmıştır. Çalışmalar arası tekrarlanabilirlik 0.73-5.41 olarak bulunmuştur. İnfA ve infB için 3-4 log10, RSV için 7 log10 aralığında dilüsyonlar ile yapılan doğrusallık analizinde her üç virüs için de r 2≥ 0.99 olarak bulunmuştur. dPCR ile ölçülen konsantrasyonların, qRT-PCR Ct sonuçları ile korele olduğu saptanmıştır. dPCR ile qRT-PCR testlerinin çalışma içi ve çalışmalar arası tekrarlanabilirlik sonuçları karşılaştırıldığında, dPCR’nin %CV değerinin anlamlı olarak daha düşük olduğu saptanmıştır (p= 0.0312). Çalışma sonuçları dPCR yönteminin, kantitatif nükleik asit standartları elde etmede tekrarlanabilirliği yüksek ve güvenilir bir yöntem olduğunu göstermiştir. Elde edilen kantitatif standartlar ile viral yük belirlemeye yönelik tanı yöntemleri geliştirmek ve/veya bu tür testlerin yöntem onayı analizlerini yapmak mümkündür. Sonuç olarak çalışmada, havuzlanmış hasta örnekleri kullanılarak dPCR yöntemiyle infA, infB ve RSV için güvenilir kantitatif nükleik asit standartlar elde edilmiş ve dPCR yönteminin performans analizleri gerçekleştirilmiştir. Bu çalışma, dPCR ile kantitatif viral nükleik asit standartlarının üretimine bir örnek olmuştur.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Workplace Violence Against Emergency Physicians: A Cross Sectional Study on the Role of Communication Skills
    (Wolters Kluwer Medknow Publications, 2025-04) Çalışkan, S. Ayhan; Hakverdi, Gülden; Karpınar, Mehmet Selim
    OBJECTIVES: Workplace violence (WPV) is a critical issue affecting healthcare professionals, posing significant risks to their safety and well being. This study investigates WPV among emergency physicians in Türkiye, examining the relationship between WPV and physicians’ communication skills. METHODS: A cross sectional study was conducted from March to June 2023, involving 63 emergency physicians recruited through a convenience sampling method. Participants completed an online survey that included demographic questions, the Turkish version of the Health Professionals Communication Skills Scale (HP CSS TR), and self evaluation items on communication skills. RESULTS: The findings revealed high WPV prevalence, with 85.7% of participants reporting verbal aggression during their residency and 90.5% during their specialty period. Physical violence was reported by 31.7% of participants during residency and 27.0% during their specialty period. Participants’ HP CSS TR scores averaged 86.08, indicating relatively high communication skills. No significant relationships were found between HP CSS TR scores and demographic characteristics such as gender, age, or years of experience. A moderate positive correlation was observed between participants’ self evaluations and their HP CSS TR scores in the dimensions of empathy and respect, suggesting alignment between perceived and actual communication skills in these areas. Weak correlations were found in informative communication and social skills, highlighting areas for improvement in communication training programs. CONCLUSIONS: This study highlights the critical issue of WPV against emergency physicians and its association with communication skills, emphasizing the complexities of high stress environments such as emergency departments. It underscores the need for continued research and systemic interventions to enhance workplace safety and the well being of healthcare professionals.
  • Letter
    Can E-Cigarettes Be the Source of Lead Toxicity
    (AVES, 2024-11-07) Yılmaz, Seda; Kılınc, Oguz; Atik, Merve Demirci; Demirci Atik, Merve
  • Article
    Bioinformatics Based Drug Repurposing Approach for Breast and Gynecological Cancers: RECQL4/FAM13C Genes Address Common Hub Genes and Drugs
    (Galenos Publ House, 2025-01-02) Duran, Gizem Ayna; Duran, Assist. Prof. Dr. Gizem Ayna
    Objective: The prevalence of breast cancer and gynaecological cancers is high, and these cancer types can occur consecutively as secondary cancers. The aim of our study is to determine the genes commonly expressed in these cancers and to identify the common hub genes and drug components. Materials and Methods: Gene intensity values of breast cancer, gynaecological cancers such as cervical, ovarian and endometrial cancers were used from the Gene Expression Omnibus database Affymetrix Human Genome U133 Plus 2.0 Array project. Using the linear modelling method included in the R LIMMA package, genes that differ between healthy individuals and cancer patients were identified. Hub genes were determined using cytoHubba in Cytoscape program. “ShinyGo 0.80” tool was used to determine the disease-specific biological KEGG pathways. Drug.MATADOR from the ShinyGo 0.80 tool was used to predict drug-target relationships. Results: The RecQ Like Helicase 4 and Family with Sequence Similarity 13 Member C genes were found to be similarly expressed in breast cancer and gynaecological cancers. Upon KEGG pathway analyses with hub genes, Drug.MATADOR analysis with hub genes related to cancer related pathways was performed. We have determined these gene/drug interactions: NBN (targeted by Hydroxyurea), EP300 (targeted by Acetylcarnitine) and MAPK14 (targeted by Salicylate and Dibutyryl cyclic AMP). Conclusion: The drugs associated with hub genes determined in our study are not routinely used in cancer treatment. Our study offers the opportunity to identify the target genes of drugs used in breast and gynaecological cancers with the drug repurposing approach.
  • Article
    Demansın Davranışsal ve Psikolojik Belirtileri Bilgi Ölçeği’nin Türkçe Versiyonunun (DDPB-T) Geçerliliği ve Güvenilirliği: Bakıcılar Arasında Psikometrik Bir Değerlendirme
    (Turkiye Sinir ve Ruh Sagligi dernegi, 2024) Var, Levent; Güllüoğlu, Halil; Uysal, Hasan Armağan; Poyraz, Turan; Başaran, Simay; Eşkut, Neslihan
    Amaç