Kazdağlı, Hasan
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Kazdagli, H.
Kazdagli, Hasan
Kazdagli, Hasan
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hasan.kazdagli@ieu.edu.tr
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15.02. Elderly Care
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Current Staff
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Sustainable Development Goals
1NO POVERTY
0
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2ZERO HUNGER
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3GOOD HEALTH AND WELL-BEING
2
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4QUALITY EDUCATION
1
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5GENDER EQUALITY
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6CLEAN WATER AND SANITATION
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7AFFORDABLE AND CLEAN ENERGY
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8DECENT WORK AND ECONOMIC GROWTH
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9INDUSTRY, INNOVATION AND INFRASTRUCTURE
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10REDUCED INEQUALITIES
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11SUSTAINABLE CITIES AND COMMUNITIES
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12RESPONSIBLE CONSUMPTION AND PRODUCTION
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13CLIMATE ACTION
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14LIFE BELOW WATER
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15LIFE ON LAND
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16PEACE, JUSTICE AND STRONG INSTITUTIONS
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17PARTNERSHIPS FOR THE GOALS
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Documents
11
Citations
25
h-index
3
Documents
24
Citations
26
Scholarly Output
24
Articles
16
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171/402
Supervised MSc Theses
0
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0
WoS Citation Count
26
Scopus Citation Count
25
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0
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0
WoS Citations per Publication
1.08
Scopus Citations per Publication
1.04
Open Access Source
11
Supervised Theses
0
| Journal | Count |
|---|---|
| Acta Physıologıca | 5 |
| Physiology International | 2 |
| Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi | 1 |
| FEBS Open Bio | 1 |
| Gazi Medical Journal | 1 |
Current Page: 1 / 4
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24 results
Scholarly Output Search Results
Now showing 1 - 10 of 24
Article Citation - WoS: 3Citation - Scopus: 3The Effects of Mechanical Ventilation on Heart Rate Variability and Complexity in Mice(Hellenıc Veterınary Medıcal Soc, 2024-01-18) Kazdağlı, Hasan; Özel, Hf; Özbek, MaIn a variety of diseases, altered respiratory modulation is often as an early sign of autonomic dysfunc-tion. Therefore, understanding and evaluating the effects of mechanical ventilation on the autonomic nervous system is vital. The effects of mechanical ventilation on autonomic balance have been assessed by heart rate variability (HRV) using frequency domain and non-linear analysis including fractal complexity and entropy analysis in anesthetized mice. BALB/c mice (n=48) were divided into two groups: Spontaneous breathing and mechanical ventilation. The electrocardiograms were recorded. Four different types of analysis were employed: i. frequency domain analysis, ii. Poincare plots, iii. Detrended Fluctuation Analysis (DFA) and iv. Entropy analysis. An unpaired t-test was used for statistical analysis. In a ventilated group, very low frequency (VLF) and low frequency (LF) parameters were not changed, whereas the high frequency parameter was decreased compared to spontaneous breathing mice. DFA alpha 1 was significantly increased due to mechanical ventilation but DFA alpha 2 was unchanged. In Poincare plots analysis, standard deviation 2 (SD2) / standard deviation 1 (SD1) ratio was increased, however, SD1 and SD2 were not significantly affected. Also, Approximate Entropy and Sample Entropy remained unchanged. HF parameter, DFA alpha 1, and SD2/SD1 were affected by mechanical ventilation. Decreased HF and increased DFA alpha 1, further support the notion that HRV is dominated by respiratory sinus arrhythmia at high frequencies, this may be due to decreased vagal tone caused by me-chanical ventilation. This novel results of HRV analysis are important considering increased usage of HRV techniques day by day in animal models and other medical practices.Article Citation - WoS: 2Citation - Scopus: 2Right Vagotomy Alters Heart Rate Variability Temporarily and Increases Total Choline Levels in Rats(Walter de Gruyter GmbH, 2024-07-01) Barış, Elif; Ozel, Hasan Fehmı; Kazdağlı, Hasan; Özbek, MustafaObjectives: The variability in the time intervals between heartbeats, known as heart rate variability (HRV), serves as a reflection of the intricate interplay between the sympathetic and parasympathetic neural systems. While the potential asymmetric effects of the left and right branches of the vagus nerve remain uncertain, this study aims to investigate the impact of unilateral, bilateral, and atropine interventions on HRV parameters and choline levels within cardiac tissue. Methods: 40 male adult Wistar albino rats were randomly assigned to the five groups (each n=8): sham-operated, atropine, right vagotomy, left vagotomy, and bilateral vagotomy. Heart rate variability (HRV) analyses were conducted, and the levels of total choline/acetylcholine in heart tissues were quantified. Statistical analyses were performed to assess the results. Results: The bilateral vagotomy and atropine groups exhibited higher heart rates and high frequency power (HF), along with reduced low frequency power (LF). Total power (TP) remained relatively unchanged. In the bilateral vagot- omy group, DFAα1 was significantly elevated while DFAα2 was reduced significantly. SD1 and SampEn were significantly lower in both the bilateral vagotomy and atropine groups. Notably, the right vagotomy group displayed significant changes primarily in the 15th minute, particularly in time- domain parameters, HF, TP, and SD1, with a significant in- crease observed in total choline levels. Conclusions: Our results revealed that asymmetrical vagal innervation induces distinct effects on heart rate variability parameters and total choline/acetylcholine levels in heart tissues. Our findings suggest that compensatory hemody- namic recovery, possibly driven by contralateral vagal overactivity, may contribute to these observed results.Article Citation - WoS: 1Citation - Scopus: 1Using Technology To Predict the Future of Biomedical Education(Wiley, 2024-12-12) Harris, Robert A.; Kazdagli, HasanBiomedical research is currently benefiting from a technological revolution in which multiple forms of omics are permitting unprecedented characterization of molecular pathways. Likewise, medical device and Ai-assisted technologies now make diagnoses and medical imaging more accurate. The field of education is also starting to embrace how technology can promote pedagogical development and student learning. But how will this landscape look like in 2050? With the premise that collaboration will be central to teaching and learning practices, that Together, Everything Can Happen (TECH), we examine the emerging trends and innovations in biomedical education, exploring how they will influence the field's evolution and shape future teaching practices in the coming years.Conference Object Changes in Total Choline Levels in Heart Tissues of Vagotomized Rats.(Wiley, 2022) Kazdağlı, Hasan; Ozel, H. F.; Barış, Elif; Ozbek, M.[Abstract Not Available]Conference Object How Virtual Heart Ownership Influences Human Physiology(Wiley, 2025) Erdeniz, Burak; Kazdagli, HasanArticle Physiological and Inflammatory Changes to Natural and Skin-Related Trypophobic Images(Akademiai Kiado Zrt, 2025-10-07) Kazdagli, Hasan; Baris, Elif; Kipcak, Arda; Ozturk, Suleyman; Ceylan, Deniz; Demir, Ayse Banu; Erdeniz, BurakIntroduction: The immune system's inflammatory response, driven by pro-inflammatory proteins, protects against external threats. Fear and disgust-inducing stimuli have been linked to immune responses, yet their specific physiological and inflammatory mechanisms in trypophobia remain unclear. This study aimed to elucidate the inflammatory and physiological responses in relation to natural (non-skin) and skin-related trypophobic images. Material and methods: Fifty participants (n = 50) were recruited for the study, and their sensitivity to trypophobia was measured using the trypophobia questionnaire. Then, participants were randomly assigned to either the skin related or non-skin related visual exposure group and viewed trypophobic images from a computer screen. Blood samples were collected pre- and post-exposure to trypophobic images and analyzed for IL-6 and TNF-alpha using ELISA and RT-qPCR methods. Results: IL-6 and TNF-alpha protein levels significantly increased post-exposure, with IL-6 changes varying by stimulus type. mRNA expression showed significant interaction with participants' trypophobia sensitivity scores, suggesting post-transcriptional mechanisms. Heart rate variability (HRV) and heart rate were measured before, during, and after exposure using photoplethysmography. Significant changes in HRV metrics, influenced by stimulus type and trypophobia sensitivity, indicated increased sympathetic and decreased parasympathetic nervous system activity during and after exposure. Conclusions: These findings highlight the role of physiological and inflammatory responses in trypophobia, suggesting immune activation and autonomic nervous system involvement based on stimulus type and individual sensitivity. These findings not only contribute to phobia literature but also shed light on the physiological and immunological changes that take place in the bodies of individuals with high sensitivity to trypophobia.Conference Object Changes in Physiological Parameters During Everest Base Camp Trek(Wiley, 2023) Kazdağlı, Hasan; Tükel, Şermin; Tütüncü, Gözde YazgıArticle General Anesthesia and Depth of Anesthesia (DoA) Evaluation Methods in Laboratory Animals: A Comprehensive Review(Springer, 2026-03-17) Kazdagli, Hasan; Altinoluk, TulinIn preclinical research, general anesthesia is essential for humane and feasible procedures but profoundly modulates autonomic, cardiovascular, neurological, and biochemical systems, risking bias in experimental outcomes. In this review our aim was to synthesize current knowledge on commonly used general anesthetics in laboratory animals, their mechanisms and protocols across species (mice, rats, rabbits, pigs), and evidence-based methods to evaluate depth of anesthesia (DoA). Injectable agents (ketamine with alpha 2-agonists, barbiturates, propofol) and inhalational agents (isoflurane, sevoflurane, desflurane) act primarily via NMDA antagonism or GABA-A/glycine modulation, with distinct profiles for analgesia, hemodynamics, respiration, and recovery. Species-specific dosing and routes are summarized for small rodents, rabbits, and pigs, including practical considerations (e.g., thermoregulation, airway management, malignant hyperthermia risk). DoA assessment spans traditional reflex-based scoring and advanced monitoring. EEG, raw and processed indices (e.g., BIS), offers continuous cortical information but requires species-specific validation and cautious interpretation. Autonomic indicators (heart rate, blood pressure, respiratory patterns) and heart-rate variability provide complementary, noninvasive signals yet are confounded by drugs, ventilation, and surgical stimuli. Anesthetic choice is a major experimental variable. Reliable practice demands multimodal DoA monitoring that integrates reflexes, physiologic trends, and, where feasible, EEG, alongside rigorous, species-adapted protocols and transparent reporting. Priorities include validated EEG algorithms for nonhuman species, standardized autonomic indices, and broader adoption of awake models when compatible with scientific aims. These strategies will improve animal welfare and enhance the reproducibility and interpretability of preclinical findings.Article Citation - WoS: 3Citation - Scopus: 2A Simple Approach To Determine Loss of Physiological Complexity in Heart Rate Series(Iop Publishing Ltd, 2023-05-24) Özel, Hasan Fehmi; Kazdağlı, HasanThere are several ways to assess complexity, but no method has yet been developed for quantitatively calculating the 'loss of fractal complexity' under pathological or physiological states. In this paper, we aimed to quantitatively evaluate fractal complexity loss using a novel approach and new variables developed from Detrended Fluctuation Analysis (DFA) log-log graphics. Three study groups were established to evaluate the new approach: one for normal sinus rhythm (NSR), one for congestive heart failure (CHF), and white noise signal (WNS). ECG recordings of the NSR and CHF groups were obtained from PhysioNET Database and were used for analysis. For all groups Detrended Fluctuation Analysis scaling exponents (DFA alpha (1), DFA alpha (2)) were determined. Scaling exponents were used to recreate the DFA log-log graph and lines. Then, the relative total logarithmic fluctuations for each sample were identified and new parameters were computed. To do this, we used a standard log-log plane to standardize the DFA log-log curves and calculated the differences between the standardized and expected areas. We quantified the total difference in standardized areas using parameters called dS1, dS2, and TdS. Our results showed that; compared to the NSR group, DFA alpha (1) was lower in both CHF and WNS groups. However, DFA alpha (2) was only reduced in the WNSgroup and not in the CHFgroup. Newly derived parameters: dS1, dS2, and TdS were significantly lowerin the NSR group compared to the CHF and WNS groups. The new parameters derived from the DFA log-log graphs are highly distinguishing for congestive heart failure and white noise signal. In addition, it may be concluded that a potential feature of our approach can be beneficial in classifying the severity of cardiac abnormalities.Article Effect of Telerehabilitation-Based Music Therapy and Motor Imagery on Pain, Autonomic Function, and Psychosocial Outcomes in People With Multiple Sclerosis: A Randomized Controlled Trial Protocol(Wiley, 2026-03-06) Yavas, Ipek; Kahraman, Turhan; Kazdagli, Hasan; Gozubatik-Celik, Rabia Gokcen; Karakas, Hilal; Seebacher, Barbara; Ertekin, OzgeBackground and Purpose Chronic pain affects approximately 63% of people with multiple sclerosis (pwMS), contributing to fatigue, depression, anxiety, poor sleep, reduced quality of life, and cognitive decline. Within the biopsychosocial model, music therapy has emerged as a promising intervention to address these complex symptoms. This study aims to examine the effects of heart rate-synchronized music therapy combined with motor imagery practice on pain, autonomic and cognitive functions, and psychosocial outcomes in patients with pwMS. We hypothesize that the combined intervention will lead to greater improvements than music therapy alone or routine care. Methods A double-blind, randomized, and three-arm parallel trial will be conducted with 45 patients with pwMS experiencing chronic pain. Participants will be randomly assigned to one of three groups: (1) heart rate-synchronized music therapy combined with motor imagery, (2) heart rate-synchronized music therapy alone, or (3) a control group receiving routine care. Interventions will be delivered twice weekly for 8 weeks, with each session lasting 20-30 min. The experimental groups will receive music therapy via videoconferencing. Assessments will be conducted at baseline, post-intervention (week 8), and follow-up (week 12). The primary outcome is pain intensity. Secondary outcomes include neuropathic pain, central sensitization, heart rate variability, anxiety, depression, fatigue, sleep quality, quality of life, and cognitive function. Sample size was calculated using G*Power; HRV data will be analyzed with Kubios software. Statistical analyses will be performed using SPSS and GraphPad Prism 10. Results Following randomization, baseline data will be collected. Blinded assessors will evaluate all outcomes at follow-up points. An independent researcher will perform statistical analyses to assess changes across time and between groups. Discussion This study may provide evidence supporting a novel, non-pharmacological, and telehealth-compatible intervention for chronic pain in pwMS.
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