Kazdağlı, Hasan
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Kazdagli, H.
Kazdagli, Hasan
Kazdagli, Hasan
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hasan.kazdagli@ieu.edu.tr
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15.02. Elderly Care
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Current Staff
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Documents
11
Citations
25
h-index
3
Documents
24
Citations
26
Scholarly Output
22
Articles
14
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46/181
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0
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0
WoS Citation Count
26
Scopus Citation Count
25
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3
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3
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0
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0
WoS Citations per Publication
1.18
Scopus Citations per Publication
1.14
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10
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| Journal | Count |
|---|---|
| Acta Physıologıca | 5 |
| Physiology International | 2 |
| Celal Bayar Üniversitesi Sağlık Bilimleri Enstitüsü Dergisi | 1 |
| FEBS Open Bio | 1 |
| Gazi Medical Journal | 1 |
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Now showing 1 - 10 of 22
Article Citation - WoS: 3Citation - Scopus: 3The Effects of Mechanical Ventilation on Heart Rate Variability and Complexity in Mice(Hellenıc Veterınary Medıcal Soc, 2023) Kazdağlı, Hasan; Özel, Hf; Özbek, MaIn a variety of diseases, altered respiratory modulation is often as an early sign of autonomic dysfunc-tion. Therefore, understanding and evaluating the effects of mechanical ventilation on the autonomic nervous system is vital. The effects of mechanical ventilation on autonomic balance have been assessed by heart rate variability (HRV) using frequency domain and non-linear analysis including fractal complexity and entropy analysis in anesthetized mice. BALB/c mice (n=48) were divided into two groups: Spontaneous breathing and mechanical ventilation. The electrocardiograms were recorded. Four different types of analysis were employed: i. frequency domain analysis, ii. Poincare plots, iii. Detrended Fluctuation Analysis (DFA) and iv. Entropy analysis. An unpaired t-test was used for statistical analysis. In a ventilated group, very low frequency (VLF) and low frequency (LF) parameters were not changed, whereas the high frequency parameter was decreased compared to spontaneous breathing mice. DFA alpha 1 was significantly increased due to mechanical ventilation but DFA alpha 2 was unchanged. In Poincare plots analysis, standard deviation 2 (SD2) / standard deviation 1 (SD1) ratio was increased, however, SD1 and SD2 were not significantly affected. Also, Approximate Entropy and Sample Entropy remained unchanged. HF parameter, DFA alpha 1, and SD2/SD1 were affected by mechanical ventilation. Decreased HF and increased DFA alpha 1, further support the notion that HRV is dominated by respiratory sinus arrhythmia at high frequencies, this may be due to decreased vagal tone caused by me-chanical ventilation. This novel results of HRV analysis are important considering increased usage of HRV techniques day by day in animal models and other medical practices.Article Citation - WoS: 1Citation - Scopus: 1Using Technology To Predict the Future of Biomedical Education(Wiley, 2024) Harris, Robert A.; Kazdagli, HasanBiomedical research is currently benefiting from a technological revolution in which multiple forms of omics are permitting unprecedented characterization of molecular pathways. Likewise, medical device and Ai-assisted technologies now make diagnoses and medical imaging more accurate. The field of education is also starting to embrace how technology can promote pedagogical development and student learning. But how will this landscape look like in 2050? With the premise that collaboration will be central to teaching and learning practices, that Together, Everything Can Happen (TECH), we examine the emerging trends and innovations in biomedical education, exploring how they will influence the field's evolution and shape future teaching practices in the coming years.Article Konjestif Kalp Yetmezliği ve Atriyal Fibrilasyon Hastalarında Kalp Atım Hızı Değişkenliği Parametrelerinin Değerlendirilmesi(2024) Kazdağlı, Hasan; Özel, Hasan FehmiGiriş ve Amaç: Konjestif kalp yetmezliği (KKY) ve atriyal fibrilasyon (AF) hastalarında ani kardiyak ölüm, bu hastalardaki ölümlerin önemli bir kısmını oluşturur. Ani ölüm riskini tahmin etmek için birçok parametre kullanılmaktadır. Ancak kalp atım hızı değişkenliği (KHD), yüksek tahmin gücü, düşük maliyet ve girişimsel olmayan bir ölçüm yöntemi olarak öne çıkmaktadır. Bazı KHD parametreleri, KKY hastalarında bağımsız prognostik bilgi sağlamıştır. Biz de bu çalışmada normal sinüs ritme sahip bireylerde, konjestif kalp yetmezliği (KKY) ve AF hastalarında KHD parametrelerini karşılaştırarak, bu hastalarda hangi parametreleri kullanmanın daha doğru olacağını göstermeyi amaçladık. Gereç ve Yöntemler: Çalışmamızda, Physionet Elektrokardiyografi (EKG) veritabanları kullanıldı. Kayıtlar üç grupta incelendi: Normal Sinüs Ritmi (NSR, n=18), Konjestif Kalp Yetersizliği (KKY, n=30) ve Atriyal Fibrilasyon (AF, n=30). KHD analizleri ile zaman-tabanlı, frekans-tabanlı ve doğrusal olmayan parametreler elde edildi. Tüm gruplar arasında doğrusal olmayan parametrelerin varyasyonlarını test etmek için parametrik olmayan bağımsız örnekler Kruskal Wallis testi, Dunn düzeltmesi ile birlikte kullanıldı. İstatistiksel anlamlılık düzeyi p < 0,05 olarak kabul edildi. Bulgular: Zaman-tabanlı parametreler incelendiğinde, AF grubunda ortalama kalp hızı, Atımlar arasındaki mesafenin standart sapması (SDNN), bu standart sapmanın karekök ortalaması (RMSSD)'nın NSR ve KKY gruplarına göre yüksek olduğu görüldü. Stres endeksi ise AF grubunda daha düşüktü. Frekans-tabanlı parametrelerde ise NSR grubunda çok düşük frekans (VLF)'ın diğer gruplara göre yüksek olduğu, sempatovagal dengenin ise KKY ve AF gruplarında, NSR grubuna göre arttığı görüldü. Doğrusal olmayan analizlerde DFAα1’in KKY ve AF gruplarında NSR grubuna göre arttığı gözlemlendi. Sonuç: Bulgularımız, doğrusal KHD parametrelerinin AF hastalarında, daha az güvenilir sonuçlar gösterdiğini ortaya koymaktadır. Bu bulgular, KHD parametrelerinin sinüs ritme sahip bireylerde risk sınıflandırması için önemli bir araç olabileceğini ancak, sinüs ritme sahip olmayan bireylerde daha fazla araştırma ve özellikle doğrusal olmayan analiz yöntemlerinin geliştirilmesi gerektiğini göstermektedir.Conference Object Citation - WoS: 1Exam Anxiety Evaluation by Heart Rate Variability in University Students(Wiley, 2023) Kazdagli, Hasan; Ozel, Hasan Fehmi; Ozturk, Suleyman; Ozalp, Deniz Ceylan Tufan; Erdeniz, Burak; Ozbek, Mustafa; Şemin, Makbule İlgi[Abstract Not Available]Article Citation - WoS: 3Citation - Scopus: 2A Simple Approach To Determine Loss of Physiological Complexity in Heart Rate Series(Iop Publishing Ltd, 2023) Özel, Hasan Fehmi; Kazdağlı, HasanThere are several ways to assess complexity, but no method has yet been developed for quantitatively calculating the 'loss of fractal complexity' under pathological or physiological states. In this paper, we aimed to quantitatively evaluate fractal complexity loss using a novel approach and new variables developed from Detrended Fluctuation Analysis (DFA) log-log graphics. Three study groups were established to evaluate the new approach: one for normal sinus rhythm (NSR), one for congestive heart failure (CHF), and white noise signal (WNS). ECG recordings of the NSR and CHF groups were obtained from PhysioNET Database and were used for analysis. For all groups Detrended Fluctuation Analysis scaling exponents (DFA alpha (1), DFA alpha (2)) were determined. Scaling exponents were used to recreate the DFA log-log graph and lines. Then, the relative total logarithmic fluctuations for each sample were identified and new parameters were computed. To do this, we used a standard log-log plane to standardize the DFA log-log curves and calculated the differences between the standardized and expected areas. We quantified the total difference in standardized areas using parameters called dS1, dS2, and TdS. Our results showed that; compared to the NSR group, DFA alpha (1) was lower in both CHF and WNS groups. However, DFA alpha (2) was only reduced in the WNSgroup and not in the CHFgroup. Newly derived parameters: dS1, dS2, and TdS were significantly lowerin the NSR group compared to the CHF and WNS groups. The new parameters derived from the DFA log-log graphs are highly distinguishing for congestive heart failure and white noise signal. In addition, it may be concluded that a potential feature of our approach can be beneficial in classifying the severity of cardiac abnormalities.Conference Object The Effects of Bilateral and Unilateral Vagotomy on Heart Rate Dynamics(Wiley, 2022) Kazdagli, Hasan; Ozel, Hasan Fehmi; Ozbek, Mustafa[Abstract Not Available]Article Citation - WoS: 2Citation - Scopus: 2Right Vagotomy Alters Heart Rate Variability Temporarily and Increases Total Choline Levels in Rats(Walter de Gruyter GmbH, 2024) Barış, Elif; Ozel, Hasan Fehmı; Kazdağlı, Hasan; Özbek, MustafaObjectives: The variability in the time intervals between heartbeats, known as heart rate variability (HRV), serves as a reflection of the intricate interplay between the sympathetic and parasympathetic neural systems. While the potential asymmetric effects of the left and right branches of the vagus nerve remain uncertain, this study aims to investigate the impact of unilateral, bilateral, and atropine interventions on HRV parameters and choline levels within cardiac tissue. Methods: 40 male adult Wistar albino rats were randomly assigned to the five groups (each n=8): sham-operated, atropine, right vagotomy, left vagotomy, and bilateral vagotomy. Heart rate variability (HRV) analyses were conducted, and the levels of total choline/acetylcholine in heart tissues were quantified. Statistical analyses were performed to assess the results. Results: The bilateral vagotomy and atropine groups exhibited higher heart rates and high frequency power (HF), along with reduced low frequency power (LF). Total power (TP) remained relatively unchanged. In the bilateral vagot- omy group, DFAα1 was significantly elevated while DFAα2 was reduced significantly. SD1 and SampEn were significantly lower in both the bilateral vagotomy and atropine groups. Notably, the right vagotomy group displayed significant changes primarily in the 15th minute, particularly in time- domain parameters, HF, TP, and SD1, with a significant in- crease observed in total choline levels. Conclusions: Our results revealed that asymmetrical vagal innervation induces distinct effects on heart rate variability parameters and total choline/acetylcholine levels in heart tissues. Our findings suggest that compensatory hemody- namic recovery, possibly driven by contralateral vagal overactivity, may contribute to these observed results.Conference Object Changes in Physiological Parameters During Everest Base Camp Trek(Wiley, 2023) Kazdağlı, Hasan; Tükel, Şermin; Tütüncü, Gözde YazgıArticle Citation - Scopus: 2Behavioral Immune System and Trypophobia(Klinik Psikiyatri Dergisi, 2022) Ozturk, Suleyman; Ceylan, Deniz; Demir, Ayse Banu; Kazdagli, Hasan; Erdeniz, BurakPathogens, which are the source of infectious diseases, have imposed a strong selection pressure on human evo-lution as one of the most important causes of human death during the natural selection process. As a result of this, it is assumed that a variety of adaptations have evolved against infection threats and one of these adap-tations is the physiological immune system. However, activation of the physiological immune system can be quite costly for organisms in some cases, and therefore it has been recently proposed in evolutionary psychology that an adaptive system called behavioral immune sys-tem may have evolved in association with the proactive functional processes against pathogen threats. Furthermore, it was hypothesized that a number of psy-chopathologies might develop as a result of maladaptive processes affecting the functionality of this system, and one of these psychopathologies might be trypophobia. Trypophobia refers to a psychological disorder in which individuals experience aversion and disgust at excessive levels toward clusters of small objects such as holes and bumps. Following this, the current review was estab-lished within the framework of three distinct goals. Firstly, this review aimed to discuss the evolutionary basis and mechanisms of the behavioral immune system. Secondly, the review aimed to discuss the characteristic features and the etiological explanations of trypophobia. Finally, the review aimed to discuss how potential changes in the behavioral immune system might lead to the development of trypophobia.Conference Object Effects of Choline and Cdp-Choline on Heart Rate Variability and Total Choline Levels in Rats.(Wiley, 2022) Kazdağlı, Hasan; Alpay, S.; Barış, Elif; Ozel, H. F.[Abstract Not Available]
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