Diversity-Sensitive Brain Clocks Linked to Biophysical Mechanisms in Aging and Dementia
| dc.contributor.author | Coronel-Oliveros, Carlos | |
| dc.contributor.author | Moguilner, Sebastian | |
| dc.contributor.author | Hernandez, Hernan | |
| dc.contributor.author | Cruzat, Josephine | |
| dc.contributor.author | Baez, Sandra | |
| dc.contributor.author | Medel, Vicente | |
| dc.contributor.author | Ibanez, Agustin | |
| dc.date.accessioned | 2025-11-03T17:00:58Z | |
| dc.date.available | 2025-11-03T17:00:58Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Brain clocks track the deviations between predicted brain age and chronological age (brain age gaps, BAGs). These BAGs can be used to measure accelerated aging, monitoring deviations from the healthy brain trajectories associated with brain diseases and different cumulative burdens. However, the underlying biophysical mechanisms associated with BAGs in aging and dementia remain unclear. Here we combine source space connectivity (via electroencephalography) with generative brain modeling in healthy controls from the global south and north, alongside patients with Alzheimer's disease and behavioral variant frontotemporal dementia (bvFTD) (N = 1,399). BAGs in aging were influenced by geography (south > north), income (low > high), sex (female > male) and education (low > high), with larger BAGs in patients, especially females, with Alzheimer's disease. Biophysical modeling revealed BAGs related to hyperexcitability and structural disintegration in aging, while hypoexcitability and severe disintegration were linked to dementia. Our work sheds light on the biophysical mechanisms of accelerated aging and dementia in diverse populations. | en_US |
| dc.description.sponsorship | This work was supported by Latin American Brain Health Institute (BrainLat) # BL-SRGP2020-02 awarded to MAP and AI. AI is supported by grants from ReDLat [National Institutes of Health and the Fogarty International Center (FIC), National Institutes of Agin | en_US |
| dc.description.sponsorship | This work was supported by Latin American Brain Health Institute (BrainLat) award BL-SRGP2020-02 to M.A.P. and A.I. A.I. is supported by grants from ReDLat (National Institutes of Health and the Fogarty International Center (FIC), the National Institutes of Aging (R01 AG057234, R01 AG075775, AG021051, R01 AG083799, CARDS-NIH 75N95022C00031), Alzheimer's Association (SG-20-725707), Rainwater Charitable Foundation, The Bluefield project to cure FTD and the Global Brain Health Institute), ANID/FONDECYT Regular (1210195, 1210176 and 1220995) and ANID/FONDAP/15150012. A.M.G. is partially supported by the National Institute On Aging of the National Institutes of Health (R01 AG075775, R01 AG083799, 2P01AG019724), ANID (FONDECYT Regular 1210176, 1210195) and DICYT-USACH (032351G_DAS). The contents of this publication are solely the author's responsibility and do not represent the official views of these institutions. | en_US |
| dc.identifier.doi | 10.1038/s44220-025-00502-7 | |
| dc.identifier.issn | 2731-6076 | |
| dc.identifier.scopus | 2-s2.0-105016555788 | |
| dc.identifier.uri | https://doi.org/10.1038/s44220-025-00502-7 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14365/6528 | |
| dc.language.iso | en | en_US |
| dc.publisher | SpringerNature | en_US |
| dc.relation.ispartof | Nature Mental Health | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Diversity-Sensitive Brain Clocks Linked to Biophysical Mechanisms in Aging and Dementia | en_US |
| dc.type | Article | en_US |
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| gdc.author.wosid | Yıldırım, Ebru/Aab-3485-2020 | |
| gdc.author.wosid | Aktürk, Tuba/R-2374-2019 | |
| gdc.author.wosid | Cruzat, Josephine/Aax-4082-2020 | |
| gdc.author.wosid | Prado, Pavel/O-2711-2019 | |
| gdc.author.wosid | Herrera, Eduar/Ixd-5515-2023 | |
| gdc.author.wosid | Hernandez, Hernan/Jdv-5631-2023 | |
| gdc.author.wosid | Yerlikaya, Deniz/Kii-9979-2024 | |
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| gdc.description.department | İzmir Ekonomi Üniversitesi | en_US |
| gdc.description.departmenttemp | [Coronel-Oliveros, Carlos; Moguilner, Sebastian; Hernandez, Hernan; Cruzat, Josephine; Medel, Vicente; Cuadros, Jhosmary; Legaz, Agustina; Fittipaldi, Sol; Gonzalez-Gomez, Raul; Herzog, Ruben; Prado, Pavel; Tagliazucchi, Enzo; Ibanez, Agustin] Univ Adolfo Ibanez, Latin Amer Brain Hlth Inst, Santiago, Chile; [Coronel-Oliveros, Carlos; Baez, Sandra; Fittipaldi, Sol; Whelan, Robert; Lawlor, Brian; Ibanez, Agustin] Trinity Coll Dublin, Global Brain Hlth Inst GBHI, Dublin, Ireland; [Coronel-Oliveros, Carlos; Baez, Sandra; Fittipaldi, Sol; Whelan, Robert; Lawlor, Brian; Ibanez, Agustin] Univ Dublin, Trinity Coll Dublin, Dublin, Ireland; [Moguilner, Sebastian] Harvard Med Sch, Boston, MA USA; [Baez, Sandra] Univ los Andes, Bogota, Colombia; [Cuadros, Jhosmary] Univ Tecn Federico Santa Maria, Adv Ctr Elect & Elect Engn, Valparaiso, Chile; [Cuadros, Jhosmary] Univ Nacl Expt Tachira, Grp Bioingn, Decanato Invest, San Cristobal, Venezuela; [Santamaria-Garcia, Hernando] Pontificia Univ Javeriana, PhD Program Neurosci Bogota, San Ignacio, Colombia; [Santamaria-Garcia, Hernando] Hosp Univ San Ignacio Bogota, Ctr Memory & Cognit Intellectus, San Ignacio, Colombia; [Valdes-Sosa, Pedro A.] Univ Elect Sci & Technol China, Clin Hosp Chengdu Brain Sci, Chengdu, Peoples R China; [Valdes-Sosa, Pedro A.] Cuban Neurosci Ctr, Havana, Cuba; [Lopera, Francisco; Ochoa-Gomez, John Fredy] Univ Antioquia, Grp Neurociencias Antioquia, Medellin, Colombia; [Gonzalez-Hernandez, Alfredis] Univ Surcolombiana, Master programme Clin Neuropsychol, Neiva, Colombia; [Bonilla-Santos, Jasmin] Univ Cooperat Colombia, Dept Psychol, Medellin, Colombia; [Gonzalez-Montealegre, Rodrigo A.] Univ Surcolombiana, Neurocognit & Psychophysiol Lab, Neiva, Colombia; [Akturk, Tuba; Yildirim, Ebru; Guntekin, Bahar] Istanbul Medipol Univ, Hlth Sci & Technol Res Inst SABITA, Istanbul, Turkiye; [Anghinah, Renato] Univ Sao Paulo, Reference Ctr Behav Disturbances & Dementia, Sch Med, Sao Paulo, Brazil; [Anghinah, Renato] Univ Sao Paulo, Traumat Brain Injury Cognit Rehabil Out Patient Ct, Sao Paulo, Brazil; [Legaz, Agustina] Univ San Andres, Cognit Neurosience Ctr, Buenos Aires, Argentina; [Fittipaldi, Sol; Whelan, Robert] Trinity Coll Dublin, Sch Psychol, Dublin, Ireland; [Yener, Gorsev G.] Izmir Univ Econ, Fac Med, Izmir, Turkiye; [Yener, Gorsev G.] Dokuz Eylul Univ, Brain Dynam & Multidisciplinary Res Ctr, Izmir, Turkiye; [Yener, Gorsev G.] Izmir Biomed & Genome Ctr, Izmir, Turkiye; [Escudero, Javier] Univ Edinburgh, Inst Imaging Data & Commun, Sch Engn, Edinburgh, Scotland; [Babiloni, Claudio; Lopez, Susanna] Sapienza Univ Rome, Dept Physiol & Pharmacol V Erspamer, Rome, Italy; [Babiloni, Claudio] Hosp San Raffaele Cassino, Cassino, Italy; [Fernandez, Alberto] Univ Complutense Madrid, Dept Legal Med Psychiat & Pathol, Madrid, Spain; [Huepe, David] Univ Adolfo Ibanez, Ctr Social & Cognit Neurosci CSCN, Sch Psychol, Santiago, Chile; [Di Caterina, Gaetano] Univ Strathclyde, Dept Elect & Elect Engn, Glasgow, Scotland; [Soto-Anari, Marcio] Univ Catolica San Pablo, Arequipa, Peru; [Herrera, Eduar] Univ ICESI, Dept Estudios Psicol, Cali, Colombia; [Abasolo, Daniel] Univ Surrey, Fac Engn & Phys Sci, Ctr Biomed Engn, Sch Mech Engn Sci, Guildford, England; [Kilborn, Kerry] Univ Glasgow, Sch Psychol, Glasgow, Scotland; [Rubido, Nicolas] Univ Aberdeen, Inst Complex Syst & Math Biol, Aberdeen, Scotland; [Clark, Ruaridh] Univ Strathclyde, Ctr Signal & Image Proc, Dept Elect & Elect Engn, Strathclyde, Scotland; [Herzog, Ruben] Sorbonne Univ, Paris Brain Inst, Inst Cerveau, ICM, Paris, France; [Yerlikaya, Deniz] Dokuz Eylul Univ, Hlth Sci Inst, Dept Neurosci, Izmir, Turkiye; [Guntekin, Bahar] Istanbul Medipol Univ, Sch Med, Dept Biophys, Istanbul, Turkiye; [Deco, Gustavo] Univ Pompeu Fabra, Ctr Brain & Cognit, Computat Neurosci Grp, Barcelona, Spain; [Deco, Gustavo] Max Planck Inst Human Cognit & Brain Sci, Dept Neuropsychol, Leipzig, Germany; [Deco, Gustavo] Inst Catalana Recerca & Estudis Avancats ICREA, Barcelona, Spain; [Deco, Gustavo] Monash Univ, Turner Inst Brain & Mental Hlth, Clayton, Vic, Australia; [Prado, Pavel] Univ San Sebastian, Escuela Fonoaudiol, Fac Odontol & Ciencias Rehabil, Santiago, Chile; [Parra, Mario A.] Univ Strathclyde, Dept Psychol Sci & Hlth, Glasgow, Scotland; [Orio, Patricio] Univ Valparaiso, Ctr Interdisciplinario Neurociencia Valparaiso CIN, Valparaiso, Chile; [Orio, Patricio] Univ Valparaiso, Fac Ciencias, Inst Neurociencia, Valparaiso, Chile; [Ibanez, Agustin] Univ San Andres, Cognit Neurosci Ctr, Buenos Aires, Argentina; [Ibanez, Agustin] Consejo Nacl Invest Cient & Tecn, Buenos Aires, Argentina | en_US |
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| gdc.oaire.keywords | brain clocks; biophysical modeling; dementia; electroencephalography; E/I balance; structural disintegration; Global south. | |
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