Diversity-Sensitive Brain Clocks Linked to Biophysical Mechanisms in Aging and Dementia
| dc.contributor.author | Coronel-Oliveros, Carlos | |
| dc.contributor.author | Moguilner, Sebastian | |
| dc.contributor.author | Hernandez, Hernan | |
| dc.contributor.author | Cruzat, Josephine | |
| dc.contributor.author | Baez, Sandra | |
| dc.contributor.author | Medel, Vicente | |
| dc.contributor.author | Ibanez, Agustin | |
| dc.date.accessioned | 2025-11-03T17:00:58Z | |
| dc.date.available | 2025-11-03T17:00:58Z | |
| dc.date.issued | 2025 | |
| dc.description.abstract | Brain clocks track the deviations between predicted brain age and chronological age (brain age gaps, BAGs). These BAGs can be used to measure accelerated aging, monitoring deviations from the healthy brain trajectories associated with brain diseases and different cumulative burdens. However, the underlying biophysical mechanisms associated with BAGs in aging and dementia remain unclear. Here we combine source space connectivity (via electroencephalography) with generative brain modeling in healthy controls from the global south and north, alongside patients with Alzheimer's disease and behavioral variant frontotemporal dementia (bvFTD) (N = 1,399). BAGs in aging were influenced by geography (south > north), income (low > high), sex (female > male) and education (low > high), with larger BAGs in patients, especially females, with Alzheimer's disease. Biophysical modeling revealed BAGs related to hyperexcitability and structural disintegration in aging, while hypoexcitability and severe disintegration were linked to dementia. Our work sheds light on the biophysical mechanisms of accelerated aging and dementia in diverse populations. | en_US |
| dc.description.sponsorship | This work was supported by Latin American Brain Health Institute (BrainLat) # BL-SRGP2020-02 awarded to MAP and AI. AI is supported by grants from ReDLat [National Institutes of Health and the Fogarty International Center (FIC), National Institutes of Agin | en_US |
| dc.description.sponsorship | This work was supported by Latin American Brain Health Institute (BrainLat) award BL-SRGP2020-02 to M.A.P. and A.I. A.I. is supported by grants from ReDLat (National Institutes of Health and the Fogarty International Center (FIC), the National Institutes of Aging (R01 AG057234, R01 AG075775, AG021051, R01 AG083799, CARDS-NIH 75N95022C00031), Alzheimer's Association (SG-20-725707), Rainwater Charitable Foundation, The Bluefield project to cure FTD and the Global Brain Health Institute), ANID/FONDECYT Regular (1210195, 1210176 and 1220995) and ANID/FONDAP/15150012. A.M.G. is partially supported by the National Institute On Aging of the National Institutes of Health (R01 AG075775, R01 AG083799, 2P01AG019724), ANID (FONDECYT Regular 1210176, 1210195) and DICYT-USACH (032351G_DAS). The contents of this publication are solely the author's responsibility and do not represent the official views of these institutions. | en_US |
| dc.description.sponsorship | Rainwater Charitable Foundation, RCF; Fondo de Innovación para la Competitividad, FIC; Agencia Nacional de Investigación y Desarrollo, ANID; National Institutes of Health, NIH; Fogarty International Center, FIC; Global Brain Health Institute, GBHI; Latin American Brain Health Institute, (BL-SRGP2020-02); Departamento de Investigaciones Científicas y Tecnológicas, Universidad de Santiago de Chile, DICYT, (032351G_DAS); Fondo Nacional de Desarrollo Científico y Tecnológico, FONDECYT, (1220995, ANID/FONDAP/15150012, 1210176, 1210195); National Institute on Aging, NIA, (R01 AG075775, AG021051, R01 AG083799, R01 AG057234, CARDS-NIH 75N95022C00031); Alzheimer's Association, AA, (SG-20-725707); National Institute, (2P01AG019724) | |
| dc.identifier.doi | 10.1038/s44220-025-00502-7 | |
| dc.identifier.issn | 2731-6076 | |
| dc.identifier.scopus | 2-s2.0-105016555788 | |
| dc.identifier.uri | https://doi.org/10.1038/s44220-025-00502-7 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14365/6528 | |
| dc.language.iso | en | en_US |
| dc.publisher | SpringerNature | en_US |
| dc.relation.ispartof | Nature Mental Health | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | Diversity-Sensitive Brain Clocks Linked to Biophysical Mechanisms in Aging and Dementia | en_US |
| dc.type | Article | en_US |
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| gdc.author.id | Orio, Patricio/0000-0003-0332-8098 | |
| gdc.author.id | Rubido, Nicolás/0000-0002-0616-2479 | |
| gdc.author.id | Fernández, Alberto/0000-0001-9998-8343 | |
| gdc.author.id | Ibanez, Agustin/0000-0001-6758-5101 | |
| gdc.author.id | Hernandez Larzabal, Hernan/0000-0002-0597-6059 | |
| gdc.author.id | Santamaria Garcia, Hernando/0000-0001-9422-3579 | |
| gdc.author.id | Escudero, Javier/0000-0002-2105-8725 | |
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| gdc.author.wosid | Yıldırım, Ebru/Aab-3485-2020 | |
| gdc.author.wosid | Aktürk, Tuba/R-2374-2019 | |
| gdc.author.wosid | Cruzat, Josephine/Aax-4082-2020 | |
| gdc.author.wosid | Prado, Pavel/O-2711-2019 | |
| gdc.author.wosid | Herrera, Eduar/Ixd-5515-2023 | |
| gdc.author.wosid | Hernandez, Hernan/Jdv-5631-2023 | |
| gdc.author.wosid | Yerlikaya, Deniz/Kii-9979-2024 | |
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| gdc.author.wosid | Medel, Vicente/AAQ-5107-2021 | |
| gdc.author.wosid | Soto, Marcio/HOF-9913-2023 | |
| gdc.author.wosid | Fernández, Alberto/H-1927-2015 | |
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| gdc.description.department | İzmir Ekonomi Üniversitesi | en_US |
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