Role of Proopiomelanocortin in Preventing Miscarriage
| dc.contributor.author | Ozbilgin, Kemal | |
| dc.contributor.author | Kahraman, Burcu | |
| dc.contributor.author | Atay, Coskun | |
| dc.contributor.author | Vatansever, Seda | |
| dc.contributor.author | Uluer, Elgin T. | |
| dc.contributor.author | Ozcakir, Tayfun | |
| dc.date.accessioned | 2023-06-16T14:55:17Z | |
| dc.date.available | 2023-06-16T14:55:17Z | |
| dc.date.issued | 2017 | |
| dc.description.abstract | OBJECTIVE: To compare the distribution of proopiomelanocortin (POMC) in decidua and placenta samples from missed abortion and voluntary termination cases in order to research the effects in the etiology of missed abortion. STUDY DESIGN: Decidual materials were collected from patients who were diagnosed with missed abortion (n=19) and legal voluntary termination cases (n=15) under 10 gestational weeks. Materials were divided into 2 groups for examination. For all samples, POMC primary antibody was performed by immunohistochemical staining. The number of stained cells was calculated by using the H-score technique. RESULTS: In the missed abortion group the mean age was 28.7 (18-41), and in the control group the mean age was 27.5 (21-37). POMC immunoreactivity was determined to be lower in the parenchyma and placenta of the missed abortion group than those of the control group. POMC immunoreactivities were found to be higher in both the syncytiotrophoblast and cytotrophoblast cells of the missed abortion group than those of the control group (p <0.005). CONCLUSION: POMC polypeptide precursor and process. Local production has become a paradigmatic has a role in the partiirition of POMC in placenta and decidua may influence pregnancy and may have a role in missed abortion pathogenesis. | en_US |
| dc.description.sponsorship | Celal Bayar University Scientific Research Projects Commission [2012-010] | en_US |
| dc.description.sponsorship | Supported by Celal Bayar University Scientific Research Projects Commission (FEF: Project Number 2012-010). | en_US |
| dc.identifier.issn | 0024-7758 | |
| dc.identifier.issn | 1943-3565 | |
| dc.identifier.scopus | 2-s2.0-85015706222 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.14365/3132 | |
| dc.language.iso | en | en_US |
| dc.publisher | Sci Printers & Publ Inc | en_US |
| dc.relation.ispartof | Journal of Reproductıve Medıcıne | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | abortion | en_US |
| dc.subject | missed | en_US |
| dc.subject | abortion | en_US |
| dc.subject | spontaneous | en_US |
| dc.subject | immunohistochemistry | en_US |
| dc.subject | POMC convertase | en_US |
| dc.subject | POMC enzyme | en_US |
| dc.subject | proopiomelanocortin convertase | en_US |
| dc.subject | proprotein convertase | en_US |
| dc.subject | Corticotropin-Releasing Hormone | en_US |
| dc.subject | Human Endometrium | en_US |
| dc.subject | Beta-Endorphin | en_US |
| dc.subject | Human Placenta | en_US |
| dc.subject | In-Vitro | en_US |
| dc.subject | Pregnancy | en_US |
| dc.subject | Expression | en_US |
| dc.subject | Crh | en_US |
| dc.subject | Identification | en_US |
| dc.subject | Implantation | en_US |
| dc.title | Role of Proopiomelanocortin in Preventing Miscarriage | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.wosid | uluer, elgin/AAN-2767-2021 | |
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| gdc.description.department | İzmir Ekonomi Üniversitesi | en_US |
| gdc.description.departmenttemp | [Ozbilgin, Kemal; Kahraman, Burcu; Atay, Coskun; Vatansever, Seda; Uluer, Elgin T.; Ozcakir, Tayfun] Celal Bayar Univ, Sch Med, Dept Histol & Embryol, Manisa, Turkey; Celal Bayar Univ, Sch Med, Dept Gynecol & Obstet, Manisa, Turkey; Near East Univ, Dept Histol & Embryol, Expt Hlth Sci Res Ctr, Fac Med, Nicosia, Cyprus; Izmir Univ Econ, Dept Comp Technol, Izmir, Turkey | en_US |
| gdc.description.endpage | 178 | en_US |
| gdc.description.issue | 3.Nis | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | N/A | |
| gdc.description.startpage | 173 | en_US |
| gdc.description.volume | 62 | en_US |
| gdc.description.wosquality | Q4 | |
| gdc.identifier.openalex | W3024646435 | |
| gdc.identifier.pmid | 30230786 | |
| gdc.identifier.wos | WOS:000397454900012 | |
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| gdc.oaire.keywords | Adult | |
| gdc.oaire.keywords | Pro-Opiomelanocortin | |
| gdc.oaire.keywords | Neovascularization, Pathologic | |
| gdc.oaire.keywords | Placenta | |
| gdc.oaire.keywords | Immunohistochemistry | |
| gdc.oaire.keywords | Trophoblasts | |
| gdc.oaire.keywords | Abortion, Spontaneous | |
| gdc.oaire.keywords | Pregnancy Trimester, First | |
| gdc.oaire.keywords | Young Adult | |
| gdc.oaire.keywords | Pregnancy | |
| gdc.oaire.keywords | Case-Control Studies | |
| gdc.oaire.keywords | Decidua | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Female | |
| gdc.oaire.keywords | Abortion, Missed | |
| gdc.oaire.popularity | 1.0376504E-9 | |
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| gdc.oaire.sciencefields | 03 medical and health sciences | |
| gdc.oaire.sciencefields | 0302 clinical medicine | |
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