Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.14365/5016
Title: | Ocular Flutter-Myoclonus-Ataxia Syndrome After mRNA BNT162b2 COVID-19 Vaccine: A Case Report | Authors: | Poyraz, T. Varol, A. Uysal, Armağan |
Keywords: | Ataxia myoclonus ocular flutter oligoclonal bands SARS-CoV-2 vaccine antibody clonazepam ganglioside antibody ganglioside GD 1a ganglioside GD 1b ganglioside GM1 antibody ganglioside GM2 antibody ganglioside GM3 antibody ganglioside GQ 1b antibody glucose immunoglobulin immunoglobulin G immunoglobulin M lactic acid methylprednisolone oligoclonal band tozinameran unclassified drug valproic acid adult anxiety Article ataxia bilateral kinetic tremor breathing disorder case report cerebrospinal fluid analysis clinical article coronavirus disease 2019 diffusion weighted imaging dizziness electroneuromyography electrooculography human hyperproteinorrhachia hypoventilation insomnia involuntary movement lumbar puncture male middle aged myoclonus non insulin dependent diabetes mellitus nuclear magnetic resonance imaging obesity ocular flutter polyneuropathy protein cerebrospinal fluid level saccadic eye movement sensorimotor polyneuropathy tremor unsteady gait |
Publisher: | Turkish Neuropsychiatric Society | Abstract: | Ocular flutter (OF) is a rare oculomotor syndrome. The most common etiologies are paraneoplastic, postinfectious and toxic-metabolic. However post-vaccinal etiology was rarely reported in OF. Here, we reported a post-vaccinal clinical syndrome characterized by OF-myoclonus and ataxia associated with oligoclonal bands (OCBs). A 60-year-old male who presented with dizziness, unsteady gait, involuntary movements, involuntary conjugate eye oscillations and extremity jerks that started 3 days after the second dose of mRNA BNT162b2 Covid-19 vaccine. Routine biochemical and serological analysis were within normal limits. No pathological finding was detected in brain MRI. Paraneoplastic and autoimmune encephalitis tests were unremarkable in cerebrospinal fluid (CSF). Oligoclonal bands were positive in CSF. This is the first description of the relationship between vaccines against SARS-CoV-2 and the clinical syndrome of OF, Myoclonus and Ataxia (OFMAS). Humoral immune mechanisms seem to play an important role in OFMAS. Presence of OCBs in CSF may also be associated with this condition. © 2022 by Turkish Association of Neuropsychiatry. | URI: | https://doi.org/10.29399/npa.28205 https://hdl.handle.net/20.500.14365/5016 |
ISSN: | 1300-0667 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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