TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4

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1,25-Dihydroxyvitamin D3 Induces N-Myc Downstream Regulated Gene-2 Expression in Papillary Thyroid Carcinoma Cells
(Dokuz Eylul Univ Inst Health Sciences, 2020) Sipahi, Murat; Bartik, Didem Keles; Doruk, Mehmet; Bayraktar, Firat; Oktay, Gulgun
Purpose: In addition to its role in serum calcium homeostasis, the anti-tumor function of 1,25-dihydroxyvitamin D-3 (calcitriol) in cancer development is well established. N-myc Downstream Regulated Gene 2 which functions as a tumor suppressor gene has recently been shown to be downregulated in various cancer leading to increased tumor incidence, progression and metastasis. The goal of this study was to investigate the possible effects of calcitriol treatment on NDRG2 expression in BCPAP papillary thyroid carcinoma cells. Methods: The experiments were carried on human primary thyroid follicular epithelial cells (Nthy-ori-3-1), and human papillary thyroid carcinoma cells (BCPAP). The half maximal inhibitory concentration (IC 50) of calcitriol on BCPAP cells was determined by WST-1 assay. BCPAP cells were treated with 15 and 30 mu M calcitriol for 24, 48, and 72 hours, respectively. Basal NDGR2 expression in Nthy-ori-3-1 and BCPAP cells as well as the alterations on NDRG2 expression in calcitriol treated BCPAP cells were evaluated with western blot. Results: A significant downregulation of NDRG2 was observed in BCPAP cells when compared to Nthy-ori-3-1 cells (p<0.01). IC50 dose of calcitriol was found to be 64, 54 and 43 mu M for 24, 48 and 72 hours, respectively. NDRG2 protein expression levels were significantly increased in 30 mu M calcitriol treated BCPAP cells after 48 hours (p<0.05). Conclusions: Calcitriol induced NDRG2 protein expression in BCPAP cells. We predict that calcitriol increased NDRG2 protein levels in BCPAP cells via c-Myc repression, which is upregulated by aberrant Wnt/beta-catenin signaling. Further investigation is required to enlighten the possible effect mechanisms of calcitriol in BCPAP cells.
Citation - WoS: 6
Citation - Scopus: 5
Acrylamide-Encapsulated Glucose Oxidase Inhibits Breast Cancer Cell Viability
(Walter De Gruyter Gmbh, 2020) Rrustemi, Trendelina; Geyik, Oyku Gonul; Ozkaya, Ali Burak; Ozturk, Taylan Kurtulus; Yuce, Zeynep; Kilinc, Ali
Objectives: Cancer cells modulate metabolic pathways to ensure continuity of energy, macromolecules and redoxhomeostasis. Although these vulnerabilities are often targeted individually, targeting all with an enzyme may prove a novel approach. However, therapeutic enzymes are prone to proteolytic degradation and neutralizing antibodies leading to a reduced half-life and effectiveness. We hypothesized that glucose oxidase (GOX) enzyme that catalyzes oxidation of glucose and production of hydrogen peroxide, may hit all these targets by depleting glucose; crippling anabolic pathways and producing reactive oxygen species (ROS); unbalancing redox homeostasis. Methods: We encapsulated GOX in an acrylamide layer and then performed activity assays in denaturizing settings to determine protection provided by encapsulation. Afterwards, we tested the effects of encapsulated (enGOX) and free (fGOX) enzyme on MCF-7 breast cancer cells. Results: GOX preserved 70% of its activity following encapsulation. When fGOX and enGOX treated with guanidinium chloride, fGOX lost approximately 72% of its activity, while enGOX only lost 30%. Both forms demonstrated remarkable resilience against degradation by proteinase K and inhibited viability of MCF-7 cells in an activity-dependent manner. Conclusions: Encapsulation provided protection to GOX against denaturation without reducing its activity, which would prolong half-life of the enzyme when administered intravenously.
Citation - WoS: 1
Antioxidant and Prooxidant Properties of Selected Herbs and Citrus Bergamia Risso Et Poiteau (bergamot) Used for the Management of Hyperlipidemia
(Istanbul Univ, Fac Pharmacy, 2022) Akyildiz, Zehra Ilke; Kose, Fadime Aydin; Somer, Nehir Unver
Background and Aims: In recent years, there has been an increased interest in the search for herbs to aid the management of hyperlipidemia. There is currently very little data on the simultaneous evaluation of the antioxidant and prooxidant properties of antihyperlipidemic herbs. This study was designed to evaluate the antioxidant and prooxidant properties of four antihyperlipidemic herbal drugs and also of bergamot. Methods: Antioxidant property was determined by ferric ions (Fe3+) reducing capacity (IRC), DPPH radical scavenging activity (DPPH IC50) and trolox equivalent antioxidant capacity (TEAC); deoxyribose degradation test was used for prooxidant property. Results: The highest total phenolic content (TPC) was in the myrtle leaf (ML)(135.35 +/- 3.46 mg GAE/g, p<0.05) whereas the highest total flavonoid content (TFC) was in green tea (GT) (48.76 +/- 0.69 mg QE/g, p<0.05) both of which were maintained from a pharmacy. Among the bergamot samples, the highest TPC and TFC values were in filtered fruit juice (BFFJ) as 197.35 +/- 6.29 mg GAE/100 mL; and 94.14 +/- 1.39 mg QE/100 mL; p<0.05, respectively. GT showed the highest antioxidant capacity in IRC and TEAC assays (2.29 +/- 0.12 mM TE/g; and 2.32 +/- 0.07 mmol TE/mg, p<0.05). The lowest DPPH IC50 was identified in ML from a pharmacy (6.95 +/- 0.08 mu g/mL; p<0.01). BFFJ had the highest IRC (2.94 +/- 0.031 mM TE/10 mu L), TEAC (5.14 +/- 0.084 mmol TE/10 mu L) and the lowest DPPH IC50 value (10.561 +/- 0.17 mu L). GT from a pharmacy and 1mg/mL concentration BFLFJ (filtered and lyophilized) were associated with the lowest hydroxyl radical scavenger activity (0.171 +/- 0.013 mu M MDA equivalent, p<0.05 and 0.144 +/- 0.015 mu M MDA equivalent, p<0.05). Conclusion: BFLFJ and GT got the highest attention due to high TPC, TFC, antioxidant and low prooxidant properties. Our results highlight the necessity of clarifying the value of bergamot and GT in this field with further studies.
Citation - WoS: 3
Benchmarking Service Quality Performance of Airlines in Turkey
(Eskisehir Osmangazi Univ, Fac Education, 2013) Kazancoglu, Yigit; Kazancoglu, Ipek
The aim of this study is to determine service quality factors of Turkish domestic airlines as well as ranking and benchmarking firms according to these factors using a fuzzy multicriteria decision making (MCDM) model. Exploratory factor analysis and fuzzy integral were used for extracting some independent common-factors and integrating the performance ratings of independent attributes in each common-factor, respectively. This paper is innovative in the sense that it helps airlines to identify key service quality factors, rank or benchmark firms in the industry through a fuzzy MCDM point of view, and provide an individual road map for improvement to each firm in a developing country, Turkey. This study is original in the sense that it helps firms compare their service quality criteria with competitors, identify performance insufficiencies by criteria, and choose the target competitors for improving the insufficiencies by identified and prioritized criteria through benchmarking.
Citation - WoS: 3
Biophilic Interior Design: a Case Study on the Relation Between Water Elements and Well-Being of the Users in an Educational Building
(Anadolu Univ, 2021) Nevzati, Fiona; Demirbas, O. Osman; Hasirci, Deniz
The concept of biophilia is an innate human tendency to seek connection with nature. Biophilic design is the integration of the built environment and nature, which offers an opportunity to design healthier places, resulting in lower stress and improved well-being. Water elements are considered one of the most effective biophilic design elements for the betterment of the interiors through decreased stress and improved mood. This paper examines the relationships between well-being and principles of biophilic design through indoor water elements, with specific focus on educational environments. A case study was conducted examining the effects of various indoor water elements for an entrance area of an educational building. It was found that occupants were generally content with the presence of interior water elements, and they perceived that direct access to nature made them feel more connected with it. There is a statistically significant difference between the responses of males and females, t = -2.041, p = 0.045 (p<0.05), while females perceived lowered stress when in the presence of interior water elements, males were more neutral. The research study concludes with a discussion on the means by which interior water elements can reduce stress and increase relaxation.
Clinical Management Strategies of Cardiologists in Heart Failure With Reduced Ejection Fraction
(Wiley, 2024) Kocabas, U. Umut; Ozcalik, E.; Kivrak, T.; Altin, C.; Turk, U. O.
[No abstract available]
Citation - WoS: 3
Citation - Scopus: 3
A Combination of Heart Rate-Corrected Qt Interval and Grace Risk Score Better Predict Early Mortality in Patients With Non-St Segment Elevation Acute Coronary Syndrome
(Aves, 2022) Inci, Saadet Demirtas; Tekindal, Mustafa Agah; Altinsoy, Meltem; Ozbeyaz, Nail Burak; Sunman, Hamza; Tas, Alperen; Yilmaz, Sabiye; Güllü, Hakan
Objective: This study aimed to evaluate whether the addition of heart rate-corrected QT interval prolongation to the Global Registry of Acute Coronary Events risk score improves the predictive value for early mortality in patients with non-ST segment elevation acute coronary syndrome. Methods: We retrospectively screened our database for consecutive non-ST-segment elevation acute coronary syndrome patients between January 2017 and July 2019. The demographic and clinical parameters were acquired via chart review. All electrocardiograms were reviewed by 2 physicians. QT interval was measured using the tangent method. Early mortality was defined as all-cause death observed during the hospital stay or within 30 days after discharge. Results: The final study population consisted of 283 patients, there were 17 early deaths. Ten of 59 patients with prolonged corrected QT intervals died (16.9%, P < .001). Both the Global Registry of Acute Coronary Events risk score (odds ratio: 1.032; 95% CI: 1.012-1.053; P = .002) and corrected QT interval (odds ratio: 1.026; 95% CI: 1.007-1.045; P = 0.007) independently predicted early mortality. The area under value was 0.769 (95% CI: 0.674-0.863, P < .001) for the corrected QT interval and 0.780 (95% CI:0.681-0.878; P < .001) for the Global Registry of Acute Coronary Events risk score alone. However, when the corrected QT interval and the Global Registry of Acute Coronary Events risk score were combined, it was found to be 0.808 (95% CI: 0.713-0.904, P < .001). Conclusion: This study is the first to report that prolonged corrected QT and the Global Registry of Acute Coronary Events risk score independently predict early mortality and a combination of these 2 factors may improve the predictive value for early mortality in patients with ST-segment elevation acute coronary syndrome.
Citation - WoS: 16
Citation - Scopus: 19
Comparative Analysis of Multicriteria Decision Making Methods for Postgraduate Student Selection
(Ani Yayincilik, 2010) Altunok, Taner; Özpeynirci, Özgür; Kazancoglu, Yigit; Yilmaz, Recai
Problem Statement: The educational recourses available for postgraduate education are limited compared with the resources for undergraduate education. An academic advisor is required for each graduate student. The academic staff allocates an important portion of his/her time for graduate studies of his/her students. Since the number of academic staff is limited, the number of graduate students should be limited, too. While a large number of students may attend an undergraduate course, this may not be possible for some graduate courses, which are designed especially for small student groups. Hence, the selection of postgraduate students is an important problem. The postgraduate student selection problem can be defined as selecting a subset of students from the applicants for a postgraduate program. Naturally, this problem is a multi-criteria decision-making problem since each applicant has several attributes and these attributes should be considered simultaneously during the selection process. Purpose of Study: The purpose of this study is to compare the performance of different multi criteria decision-making methods developed for ranking alternatives for the postgraduate student selection problem. The best method will also be used in the student selection process for the Defense Sciences Institute of Turkish Military Academy. Methods: This paper discusses three multi-criteria decision making methods developed for ranking alternatives, namely Analytic Hierarchy Process (AHP), Weighted Product (WP) and the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS). A performance measure is defined and the performance values of the methods are compared using real data gathered from the graduates of Defense Sciences Institute of Turkish Military Academy for illustration purposes. Findings and Results: According to the findings, AHP is the best of the three competitors. The ranking obtained by AHP is quite similar to the ranking of students with respect to their cumulative grade point average (CGPA) after their graduation from the program. Conclusions and Recommendations: Considering graduate student selection problem as a multicriteria decision-making problem is very important and enables universities to enroll graduate students with important attributes and a variety of strengths. This paper compares the performance of different multicriteria decision-making methods on graduate student selection problem using a single performance measure. A further study can be making such a comparison with multiple performance measures.
Consumers' Paradoxical Interpretations of Prestige and Luxury
(Eskisehir Osmangazi Univ, Fac Education, 2010) Ati̇k, Deniz; Oflac, Bengu Sevil
In relation to consumption, we observe puzzlement in the ways the terms prestige and luxury are interpreted both in scholarly discussions and in consumers' minds. Some use these terms interchangeably while others assign different meanings. Through our study, with a qualitative inquiry, we hope to shed light to this perplexity from consumers' perspectives. We first offer a framework about the confusion in consumers' minds related to their understanding of the notions of prestige and luxury, which can have different connotations. In addition to its material aspects, prestige may also be associated with moral values while luxury is often materialistic. Accordingly, the analysis shows these intangible, material, and interpersonal aspects of prestige. With the study, we hope to contribute to consumer behavior theories, at the same time highlighting both the limits and the success of materialism.
Citation - Scopus: 1
Contradicting Parochial Realms in Neighborhood Parks: How the Park Attributes Shape Women’s Park Use
(Istanbul Teknik Universitesi, Faculty of Architecture, 2023) Kaştaş Uzun, İpek; Şenol, F.; Kaştaş-Uzun, İpek
Neighborhood parks are significant green public spaces located in close social and geographical proximity to homes to maintain individual and public health. However, some people do not use the nearest parks, but those with other socio-spatial attributes that make them feel more “familiar”. This study argues that with their facilities, amenities and design, and the surrounding land uses, neighborhood parks do not only accommodate, but also define, regulate, and originate social relations among users. Thus, the design and planning of urban public spaces play a role in the emergence and maintenance of supportive and conflictual relations that lead to familiarity. The study answers two research questions: How do the park attributes shape and mediate the interpersonal relations among the park users? How do gender differences influence the parochial realms in parks? Data was collected through field observations and in-depth interviews with 33 female users of two neighborhood parks in a populous district of Izmir (Turkey). Results state that women’s park visits were related to their gendered roles and responsibilities. Yet their responses point to challenges emerging from physical and social attributes of parks and park surroundings which lead to negotiations to protect their individual or group’s privacy (parochial realm) in neighborhood parks. Mainly, perceived threats to women’s parochial realm are men unaccompanied by child(ren), and exposure to the male gaze. The study highlights the importance of investigating these attributes of neighborhood parks for developing research and public policies to improve women’s presence and perceived safety in public settings. © 2023, Istanbul Teknik Universitesi, Faculty of Architecture. All rights reserved.
A Convergent Algorithm for a Cascade Network of Multiplexed Dual Output Discrete Perceptrons for Linearly Nonseparable Classification
(Tubitak Scientific & Technical Research Council Turkey, 2014) Genc, Ibrahim; Guzelis, Cuneyt
In this paper a new discrete perceptron model is introduced. The model forms a cascade structure and it is capable of realizing an arbitrary classification task designed by a constructive learning algorithm. The main idea is to copy a discrete perceptron neuron's output to have a complementary dual output for the neuron, and then to select, by using a multiplexer, the true output, which might be 0 or 1 depending on the given input. Hence, the problem of realization of the desired output is transformed into the realization of the selector signal of the multiplexer. In the next step, the selector signal is taken as the desired output signal for the remaining part of the network. The repeated applications of the procedure render the problem into a linearly separable one and eliminate the necessity of using the selector signal in the last step of the algorithm. The proposed modification to the discrete perceptron brings universality with the expense of getting just a slight modification in hardware implementation.
Citation - WoS: 1
Citation - Scopus: 1
Crime and Media: the World of ‘reality Show’ as a Moral Frame of Reference
(Milli Folklor Dergisi, 2017) Erol Isik, Nuran; Yaman, Burcu
Crime and transgression has become an important factor which is portrayed by the media outlets. The genre called crime reality show situated within the genre of reality show in the media in recent years has a special place in popular cultural world of meaning. Those who are accepted as protagonists, confessors, interrogators, victims and vigilantes are among the major actors in crime reality shows which function as constructing various different cultural and sociological frames of reference. The purpose of this article is to answer to the following questions: What does the crime reality show narrative tell us about contemporary Turkish culture? What are the implications of such a genre in terms of producing a televisual morality? What are the dynamics between socially irresponsible imagination and the idea of moral panic constructed via sensibility guided reasoning? In this paper, we argue that the crime reality show genre in Turkish television employs communicative strategies which are based on mediatization of morality as well as a new trend called prudentialism.
Citation - WoS: 16
Citation - Scopus: 40
Current Evaluation and Recommendations for the Use of Artificial Intelligence Tools in Education
(Walter De Gruyter Gmbh, 2023) Sagin, Ferhan Girgin; Özkaya, Ali Burak; Tengiz, Funda; Geyik, Öykü Gönül; Geyik, Caner
This paper discusses the integration of artificial intelligence (AI) tools in education, delineating their potential to transform pedagogical practices alongside the challenges they present. Generative AI models like ChatGPT, had a disruptive impact on teaching and learning, due to their ability to create text, images, and sound, revolutionizing educational content creation and modification. However, nowadays the educational community is polarized, with some embracing AI for its accessibility and efficiency thus advocating it as an indispensable tool, while others cautioning against risks to academic integrity and intellectual development. This document is designed to raise awareness about AI tools and provide some examples of how they can be used to improve education and learning. From an educator's perspective, AI is an asset for curriculum development, course material preparation, instructional design and student assessment, while reducing bias and workload. For students, AI tools offer personalized learning experiences, timely feedback, and support in various academic activities. The Turkish Biochemical Society (TBS) Academy recommends educators to embrace and utilize AI tools to enhance educational processes, and engage in peer learning for better adaptation while maintaining a critical perspective on their utility and limitations. The transfer of AI knowledge and methods to the teaching experiences should complement and not replace the educator's creativity and critical thinking. The paper advocates for an informed embrace of AI, AI fluency among educators and students, ethical application of AI in academic settings, and continuous engagement with the evolving AI technologies, ensuring that AI tools are used to augment critical thinking and contribute positively to education and society.
Citation - WoS: 2
Citation - Scopus: 1
A De Novo Tool To Measure the Preclinical Learning Climate of Medical Faculties in Turkey
(Edam, 2015) Yilmaz, Nilufer Demiral; Velipasaoglu, Serpil; Sahin, Hatice; Basusta, Bilge Uzun; Midik, Ozlem; Coskun, Ozlem; Budakoglu, Isil Irem; İfakat Tengiz, Funda
Although several scales are used to measure general and clinical learning climates, there are no scales that assess the preclinical learning climate. Therefore, the purpose of this study was to develop an effective measurement tool in order to assess the preclinical learning climate. In this cross-sectional study, data were collected from 3,540 preclinical medical students of six medical faculties in Turkey. The methodology included the following activities: generate an item pool, receive expert opinions, perform a pretest to purify the instrument, and conduct factor and reliability analyses. According to the factor analysis, eight factors were determined and their contribution to the variance was 50.39%. In addition, the item factor loadings ranged from .31 to .91, Cronbach's alpha coefficients for the subscales ranged from .72 to .77, and the item-total correlation coefficients for the subscales ranged from .44 to .76. All the items significantly discriminated between the low- and high-performing students (t = 99.57; p = .01). The scale included 52 items with the following subscales: management, teaching, teaching staff, institutional commitment, emotions, inter-student relationships, physical environment, and motivation. The analysis of this newly developed Preclinical Learning Climate Scale (PLCS) indicated that its psychometric properties are appropriate and this scale can be employed to evaluate medical education programs.
Citation - WoS: 5
Citation - Scopus: 7
Detection of Olfactory Stimulus in Electroencephalogram Signals Using Machine and Deep Learning Methods
(Istanbul University, 2024) Akbuğday, Burak; Akbugday, S.P.; Sadikzade, R.; Akan, A.; Unal, S.; Sadighzadeh, Reza
The investigation of olfactory stimuli has become more prominent in the context of neuromarketing research over the last couple of years. Although a few studies suggest that olfactory stimuli are linked with consumer behavior and can be observed in various ways, such as via electroencephalogram (EEG), a universal method for the detection of olfactory stimuli has not been established yet. In this study, 14-channel EEG signals acquired from participants while they were presented with 2 identical boxes, scented and unscented, were processed to extract several linear and nonlinear features. Two approaches are presented for the classification of scented and unscented cases: i) using machine learning (ML) methods utilizing extracted features; ii) using deep learning (DL) methods utilizing relative sub-band power topographic heat map images. Experimental results suggest that the olfactory stimulus can be successfully detected with up to 92% accuracy by the proposed method. Furthermore, it is shown that topographic heat maps can accurately depict the response of the brain to olfactory stimuli. © 2024 Istanbul University. All rights reserved.
Citation - WoS: 1
Determination of a Sample-To Ratio To Predict True-Positivity in Blood Donor Samples Screened for Syphilis by a Chemiluminescent Immunoassay
(Aves Press Ltd, 2018) Akcakanat, I. Ebru; Ozbek, Ozgen Alpay; Dogan, Yavuz; Abacioglu, Yusuf Hakan
Purpose: The use of Architect Syphilis TP (CMIA) in the blood bank raised the number of syphilis positive samples requiring confirmation. The aim of this study is to determine a sample-to-cutoff (s/co) ratio for CMIA predicting >= 95% of true-positive samples to reduce these samples. Methods: CMIA reactive samples (n=177) were evaluated by Western blot (WB) as the reference standard, as well as by Treponema pallidum hemagglutination (TPHA) and Rapid Plasma Reagin (RPR) tests. The s/co ratio predicting >= 95% of true-positive samples was defined as the threshold leaving >= 95% of WB confirmed samples greater than the particular value. The performances of TPHA and RPR tests were also evaluated with respect to s/co ratios of CMIA positive samples. Results: The s/co ratio 15.17 predicted a true-positive result for >= 95% of samples tested (95% confidence interval: 85.9-99.3) and reduced the number of samples requiring confirmation by 29.9%. Higher s/co ratios were correlated with the increasing number of bands on WB strips (p<0.0001, R=0.906). For the samples with s/co ratios between 3 and 15.17, the agreement of TPHA and WB test results were 90%. The lowest s/co ratio where TPHA was positive, was 3.1. Although RPR predicted > 95% of positive samples with s/co ratios > 15, its sensitivity was 47.7%. Conclusion: Higher s/co ratios can be used to define true-positivity and may indicate an active infection. TPHA may replace WB to confirm samples with s/co ratios between 3 and 15. RPR should not be used as a screening test in blood banks as it could miss almost half of the true-positive samples.
Effects of Retail Lighting on Product Color Perception and User Satisfaction
(Anadolu Univ, 2022) Dilgen, Ozge; Hasirci, Deniz
Light source color properties in retail applications are among the most important factors affecting the user satisfaction in shopping places. A lighting design with a low color rendering value and an unsuitable color temperature can create a difference in the color perception of the product which may affect customers purchase decision or cause dissatisfaction resulting in the return of the product. In this study, it is aimed to evaluate the effects of lighting on product color perception and customer's feedback on the color difference. In order to fulfill this aim, the color differences of the chosen products are examined in three different key areas of a chain clothing store in Izmir, Turkey and compared with the color under daylight. Moreover, the user feedback is taken via a questionnaire to discuss the relationship between color display and user satisfaction/dissatisfaction. The collected data shows that although people do not realize the color differences inside the store, if they experience it after their purchase it may result in the return of the product. As a result of the study, it is suggested that retail store designers and lighting engineers should collaborate to ensure that the consumer perceives what the product designer intended as accurately as possible.
Enlarging Multiword Expression Dataset by Co-Training
(Scientific Technical Research Council Turkey-Tubitak, 2018) Kumova Metin, Senem
In multiword expressions (MWEs), multiple words unite to build a new unit in language. When MWE identification is accepted as a binary classification task, one of the most important factors in performance is to train the classifier with enough number of labelled samples. Since manual labelling is a time-consuming task, the performances of MWE recognition studies are limited with the size of the training sets. In this study, we propose the comparison-based and common-decision co-training approaches in order to enlarge the MWE dataset. In the experiments, the performances of the proposed approaches were compared to those of the standard co-training [1] and manual labelling where statistical and linguistic features are employed as two different views of the MWE dataset [2]. A number of tests with different settings were performed on a Turkish MWE dataset. Ten different classifiers were utilized in the experiments and the best performing classifier pair was observed to be the SMO-SMO pair. The experimental results showed that the common-decision co-training approach is an alternative to hand-labeling of large MWE datasets and both newly proposed approaches outperform the standard co-training [2] when the training set is to be enlarged in MWE classification.
Citation - WoS: 8
Citation - Scopus: 9
Evaluation of Adherence To Immunosuppressive Treatment With Different Methods in Kidney Transplant Recipients
(Turk Nefroloji Diyaliz Transplantasyon Dergisi, 2018) Sarigol Ordin, Yaprak; Karayurt, Ozgul; Ertan, Nermin; Yildiz, Serkan
OBJECTIVE: This study was conducted to compare the medication adherence levels of kidney transplant recipients using different measures. MATERIAL and METHODS: This descriptive, cross-sectional study was carried out with 147 kidney transplant recipients. The study data were collected between April and November 2017 using the Immunosuppressant Therapy Adherence Scale (ITAS), Immunosuppressive Medication Use Adherence Scale (IMUAS) and biological assay method. For the biological assay, the last five tacrolimus blood plasma levels were assessed and the standard deviation level for each patient was calculated. Patients whose standard deviation level was > 2.48 were considered to have inadequate adherence to medication. Descriptive and Spearman correlation analysis was used. RESULTS: The patients' mean age was 45.00 +/- 12.60. Of the 147 patients, 73 (49.6%) received treatment including tacrolimus. The biological assay revealed that 88.82% of the patients were in the group that complied with the medication. The mean scores obtained from the ITAS and IMUAS values for all the participating patients (n = 147) were 11.17 +/- 1.22 and 48.66 +/- 4.71 respectively. CONCLUSION: In the present study, medication adherence was evaluated using three different measures. The participating patients' self-report demonstrated that they gave higher scores for medication adherence when the ITAS was used. Several methods as appropriate to the characteristics of patients should be used simultaneously when assessing medication adherence.
Citation - WoS: 1
Evaluation of Perioperative Practices According To Eras Protocol in Elective Cesarean Surgery
(Cukurova Univ, Fac Medicine, 2020) Ozkececi, Fulden; Yavan, Tulay
Purpose: This study was conducted as a descriptive and prospective study to evaluate perioperative practices in elective cesarean operations according to the Enhanced Recovery After Surgery (ERAS) protocol. Materials and Methods: The research was conducted between 01 August 2016 and 31 May 2017 at an Education and Research Hospital Obstetrics Clinic. The sample consisted of 100 volunteer women that planning elective cesarean surgery. Data collecting form consisted of some descriptive characteristics of women and ERAS protocol proposals. Results: Mean preoperative solid food restriction time was 12,17 +/- 3,37 hours, mean preoperative fluid restriction time was 10,36 +/- 2,85 hours. 77% of women was applied spinal anesthesia; 23% of them was applied general anesthesia; in order to prevent intraoperative hypothermia, all women underwent a heating under mattress and air blankets in the wake unit. Surgical incision size was found to be 15,83 +/- 0,81 cm. Postoperatively, it was calculated that the time of remove of urinary catheter was an average of 7,99 +/- 2,86, the time of release of gas was an average of 15,29 +/- 6,36 hours and the time to start solid food was an average of 16,46 +/- 5,85 hours. Conclusion: According to the findings obtained in the study, most of the practices were compatible with the ERAS protocols. About practices that are different; It is recommended to review preoperative information, preoperative fasting, starting postoperative food intake and initiation of breastfeeding.

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