TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4

Browse

Now showing 1 - 3 of 3

Can Volumetric Magnetic Resonance Imaging Evaluations Be Helpful in the Follow-Up of Cognitive Functions in Cognitively Normal Parkinson's Disease Patients?
(Tubitak Scientific & Technological Research Council Turkey, 2024) Uysal, Hasan Armağan; Hunerli, Duygu; Çakmur, Raif; Dönmez Çolakoğlu, Beril; Ada, Emel; Yener, Görsev; Çolakoğlu, Beril Dönmez
Background/aim: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson's disease (PDCN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients. Materials and methods: Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA). Attention and executive functions were evaluated using the Wechsler memory scale-revised (WMS-R) digit span test and trail making test (TMT) part A and part B, the Stroop test, semantic and phonemic fluency tests, and clock drawing test. Magnetic resonance imaging (MRI) was acquired according to the Alzheimer's disease neuroimaging initiative (ADNI) protocol. Results: There were no significant differences among groups regarding age, sex, handedness, and years of education. In the comparison of the PD-CN group and the HC group, there was a statistical decrease in the total animal scores, lexical fluency, TMT part A and TMT part B scores in the PD-CN group. Subcortical gray matter volumes (GMV) were significantly lower in PD-CN patients. The PD-CN group had a significantly reduced total volume of right putamen and left angular gyrus compared to that in the HC group. We observed that putamen and angular gyrus volumes were lower in PD-CN patients. On the other hand, TMT part B may be a useful pretest in detecting the conversion of mild cognitive impairment in PD. Conclusion: Significant MRI volumetric measurements and neuropsychological test batteries can be helpful in the clinical follow-up in PD-CN patients.
Cortical Thickness Alterations in Parkinson's Disease With Mild Cognitive Impairment
(Galenos Publ House, 2023) Çavuşoğlu, Berrin; Hünerli, Duygu; Kıyı, İlayda; Çakmur, Raif; Yener, Görsev; Ada, Emel
Objective: This study investigated cortical thickness differences and their relationships with cognitive functions in Parkinson's disease (PD) with mild cognitive impairment (MCI) and cognitively normal (CN). Materials and Methods: Twenty-two patients with PD-MCI, 23 with PD-CN, and 23 healthy controls with structural brain magnetic resonance imaging scans and complete neuropsychological tests were enrolled in this study. Cortical thickness analysis was performed using the Statistical Parametric Mapping 12 software package. Correlations with cognitive functions were examined. Results: Cortical thickness was significantly lower in the PD-CN and PD-MCI patient groups than in healthy controls in the left precuneus and isthmus-cingulate cortex, right pars orbitalis, insula, and lateral orbitofrontal cortex. In addition, the PD-MCI group also exhibited cortical thinning in the left superior temporal gyrus, transverse temporal cortex, supramarginal gyrus, and bilateral posterior cingulate cortex compared with healthy controls. Correlation analyses among cortical thickness and cognitive scores of PD also revealed moderate associations between memory and the posterior cingulate cortex; language and the precuneus; and executive functions and the insula and isthmus-posterior cingulate cortices. Conclusion: MCI in PD may be related to cortical alterations in the posterior cingulate cortex and the left temporoparietal cortex, which has been associated with subtle cognitive deficits in PD.
White Matter Alterations in Amnestic Mild Cognitive Impairment: a Tract-Based Spatial Statistics Study
(2022) Çavuşoğlu, Berrin; Ada, Emel; Emek Savaş, Derya Durusu; Yener, Görsev
Purpose: To compare white matter (WM) structural alterations between the subjects with amnestic mild cognitive impairment (MCI) which is a transitional state to Alzheimer's Disease (AD) and healthy elderly controls. Methods: Diffusion tensor imaging (DTI) scans of 20 subjects with amnestic MCI and 20 healthy control groups who are matched by age, gender, and education with the MCI group between 2011 and 2016 were examined by in this retrospective study. WM structural integrity was analyzed using tract- based spatial statistics (TBSS) for voxel-based differences in fractional anisotropy (FA) between the two groups. Results: Fractional anisotropy was found significantly lower in the forceps minor, the body and genu of the corpus callosum, the right anterior thalamic radiation, the right cingulum, the right inferior fronto-occipital fasciculus, the right superior longitudinal fasciculus, and the right superior corona radiata in the MCI group than the control group. Conclusion: TBSS analysis is a promising method to examine structural WM integrity. These findings suggested that the DTI measurements may be useful for the detection of preclinical changes in AD.

Browse

Browsing TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection by Author "Ada, Emel"