TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4
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Browsing TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection by Publisher "AVES"
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Article Citation - WoS: 2Citation - Scopus: 2Adrenomedullin Has No Effect on Segmental Bone Defect Healing but Increases Bone Mineral Density in Rat Model(AVES, 2023) Kaymakoğlu, Mehmet; Ciftci, E.; Korkusuz, P.; Ozdemir, E.; Erden, M.E.; Turhan, E.Objective: This study aimed to investigate the effect of adrenomedullin on the healing of the segmental bone defect in a rat model. Methods: Thirty-six Wistar rats were randomly divided into 6 groups based on follow-up periods and administered a dose of adreno-medullin hormone. In each group, bilaterally, a 2-mm bone defect was created at the diaphysis of the radius. Sodium chloride solution was administered to sham groups 3 times a week for 4 and 8 weeks intraperitoneally. Adrenomedullin was administered to the study groups 3 times a week: 15 μg—4 weeks, 15 μg—8 weeks, 30 μg—4 weeks, and 30 μg—8 weeks, respectively. After euthanasia, the segmental defects were evaluated by histomorphometric [new bone area (NBA)] and microtomographic [bone volume (BV), bone surface (BS), and bone mineral density (BMD)] analyses. Results: Although the 4-and 8-week 15 μg administered study groups had higher NBA values than the other study and control groups, the histomorphometric analysis did not reveal any statistical difference between the control and study groups regarding NBA (P >.05). In microtomographic analysis, BV was higher in the 15 μg 4-week group than 30 μg 4-week group (296.9 vs. 208.5, P =.003), and BS was lower in the 30 μg 4-week group than in the 4-week control group (695.5 vs. 1334.7, P =.005), but overall, no significant difference was found between the control and study groups (P >.05). Despite these minor differences in histomorphometric and microtomographic criteria indicating new bone formation, the BMD values of the 15 μg 8-week study group showed a significant increase compared with the control group (P =.001, respectively). Conclusion: Adrenomedullin positively affected BMD at 15 μg, but this study could not show healing in the segmental defect site at different dose regimens. Further studies are needed to assess its effects on bone tissue trauma. © 2023, AVES. All rights reserved.Letter Can E-Cigarettes Be the Source of Lead Toxicity(AVES, 2025) Yılmaz, Seda; Kılınc, Oguz; Atik, Merve DemirciArticle Citation - WoS: 1Detection of Alzheimer's Dementia by Using Deep Time-Frequency Feature Extraction(AVES, 2023) Karabiber Cura, Özlem; Türe, H. Sabiha; Akan, AydinAlzheimer's disease (AD), a neurological condition connected with aging, causes cognitive deterioration and has a substantial influence on a patient's daily activities. One of the most widely used clinical methods for examining how AD affects the brain is the electroencephalogram (EEG). Handcraft calculating descriptive features for machine learning algorithms requires time and frequently increases computational complexity. Deep networks provide a practical solution to feature extraction compared to handcraft feature extraction. The proposed work employs a time-frequency (TF) representation and a deep feature extraction-based approach to detect EEG segments in control subjects (CS) and AD patients. To create EEG segments'TF representations, high-resolution synchrosqueezing transform (SST) and traditional short-time Fourier transform (STFT) approaches are utilized. For deep feature extraction, SST and STFT magnitudes are used. The collected features are classified using a variety of classifiers to determine the EEG segments of CS and AD patients. In comparison to the SST method, the STFT-based deep feature extraction strategy produced improved classification accuracy between 79.56% and 92.96%.Article Citation - WoS: 7Citation - Scopus: 7Effectiveness of a Program To Raise Awareness About Pneumococcal Vaccination Among Physicians and Patients With Chronic Respiratory Diseases: a Multicenter Cohort Study(AVES, 2024) Karakurt, Z.; Yalnız, E.; Altın, S.; Oruç, Ö.; Uslu, Ö.; Veske, N.Ş.; Kılınç, O.; Sayıner, AbdullahOBJECTIVE: There is a need to increase patient and clinician awareness on the effectiveness of pneumococcal vaccination in at-risk groups. The aim of the study was to evaluate the effect of reminders for physicians and patients using the vaccination tracking system created in the hospital information management system (HIMS) on the vaccination rate, and the effect of pneumococcal vaccination on pneumonia-related hospitalization and mortality over a 12-month period. MATERIAL AND METHODS: This prospective observational cohort study was undertaken during a 2-year period in 3 tertiary care cen-ters. Patients were followed up for 12 months following vaccination, and hospital admissions and mortality were recorded via HIMS. During the campaign, HIMS transmitted pneumococcal immunization reminder messages in accordance with guideline recommendations to physicians’ computers and patients’ mobile phones. Educational posters on pneumococcal vaccination were posted in outpatient clinics. Regular seminars on the evidence for pneumococcal vaccination were organized. All patients who were hospitalized during the follow-up period for chronic obstructive pulmonary disease (COPD), asthma, lung cancer, or pneumonia were analyzed in relation to their vaccination history regarding clinical outcomes. RESULTS: A total of 29 530 patients were included in the study. During the study period, the annual vaccination rate increased by 74.4% and reached 4.8% in 3 hospitals (P = .001). The rates were 3.9% in patients older than 65 years without comorbidities and 5.2% in those with COPD and asthma (P = .002). In pneumococcal vaccine recipients, pneumonia-related hospital mortality was lower (relative risk (RR) = 0.19, CI 0.09-0.35, P < .001). CONCLUSION: It is possible to raise the rate of pneumococcal vaccination through awareness campaigns. Individuals with COPD and asthma are more willing to receive pneumococcal vaccination. Among patients hospitalized for pneumonia, prior pneumococcal vaccination is associated with lower mortality. © Author(s).Article Evaluation of the Relationship Between Diabetic Retinopathy and the Development of Left Atrial Stiffness in Patients With Diabetes Mellitus(AVES, 2023) Birdal, Oğuzhan; Saygı, Mehmet; Doğan, Remziye; Pay, Levent; Aksakal, Emrah; Topaloglu, Caner; Yıldırım, MustafaObjective: Based on several studies, atrial remodeling results in an increase in left atrial (LA) stiffness, which is indicative of a worsened reservoir function. A typical microvascular consequence of diabetes mellitus (DM) is diabetic retinopathy. Therefore, the objective of this study was to assess the factors that might be related to LA stiffness in DM patients. Materials and Methods: There were 200 DM patients in the study population. The LA stiffness value of 0.33 led to the division of the patients into 2 groups. According to these groups, the parameters to predict the development of the LA stiffness were investigated. Results: The patient population’s median age was 54.7 ± 9.4 years, and of them, 105 (52.5% of the popula- tion) were men. Retinopathy was substantially linked with LA stiffness. Interventricular septum thickness (B coefficient: 0.261, 95% CI 0.128; 0.394; P < .001), mitral annular plane systolic excursion (B coefficient: −0.350, 95% CI −0.489; −0.2212; P < 0.001), and retinopathy (B coefficient: 0.644, 95% CI 0.307; 0.983; P < .001) were identified as independent predictors of the progression of LA stiffness by the linear regression model. Conclusion: The results of the current investigation demonstrated a correlation between higher LA stiffness values and the presence of diabetic retinopathy in diabetic patients.Article Citation - WoS: 2Matrix Metalloproteinase-2 and -3 Levels in Patients With Behçet's Disease and Implication for the Presence of Vascular Aneurysm or Neurologic Involvement(AVES, 2023) Erten, Pınar Talu; Keser, Gökhan; Durusoy, Raika; Kocaer, Sinem Burcu; Aksu, KenanBackground: Behçet's disease is a systemic vasculitis affecting both arteries and veins, as well as causing recurrent inflammatory multiorgan disease. Vascular involvement is associated with increased mortality and morbidity. Matrix metalloproteinases are released at sites of inflammation and degrade various components of the extracellular matrix. Increased levels of metalloproteinase-9 and metalloproteinase- 2 have been previously reported in Behçet's disease. Methods: In this cross-sectional study, metalloproteinase-2 and metalloproteinase-3 serum levels were investigated in 103 patients with Behçet's disease and 69 healthy controls, using Invitrogen immunoassay human metalloproteinase-2 and metalloproteinase-3 ELISA kits. Results: Serum metalloproteinase-2 and metalloproteinase-3 levels were significantly higher in the Behçet's disease group compared to healthy controls. Besides, serum metalloproteinase-3 levels were significantly higher in subgroups of Behçet's disease with aneurysmal vascular involvement and with neurological involvement. However, metalloproteinase-2 and metalloproteinase-3 serum levels did not show a positive correlation with disease activity. Conclusion: Metalloproteinase-2 and -3 may contribute to the complex pathogenesis of Behçet's disease. More importantly, the detection of very high serum levels of metalloproteinase-3 may predict the formation of an aneurysm, or possibly the presence of neurological involvement in Behçet's disease and may lead the clinician to make an earlier diagnosis of these complications in young male patients with high risk.Article Citation - Scopus: 1Operating Room Nurses’ Metaphorical Perceptions of Coronavirus Disease 2019, Quarantine, and Mask Concepts: A Qualitative Study(AVES, 2023) Savsar, Adile; Damar, Hale Turhan; Ogce, FilizAmaç: Bu çalışmanın amacı ameliyathane hemşirelerinin COVID-19, maske kullanımı ve karantina sürecine ilişkin algılarını, metaforlar aracılığıyla ortaya çıkarmaktır. Yöntemler: Bu tanımlayıcı kalitatif çalışma ameliyathane hemşireleri ile yapılmıştır (n = 96). Çalışma verileri tanıtıcı özellikler formu ve yarı yapılandırılmış form kullanılarak Eylül 2020-Mart 2021 tarihleri arasında toplanmıştır. Ameliyathane hemşirelerinden “COVID-19”, “maske kullanımı” ve “karantina süreci” kavramlarını neye benzettiklerini, benzetme nedeniyle birlikte yazması istenmiştir. Veriler, “içerik analizi” yöntemiyle incelenmiştir. Bulgular: Araştırmadaki üç farklı kavrama ilişkin toplam 181 metafor üretilmiştir. “COVID-19” kavramına ilişkin benzetmeler “Kontaminasyon ve mutasyon,” “Zarar verici” ve “Başetme ve uyum süreci” olarak üç kategoride toplanmıştır. “Karantina süreci” kavramına ilişkin benzetmeler “Özgürlüğün Kısıtlaması” ve “Değişim Süreci” olarak iki kategoride toplanmıştır. “Maske kullanımı” kavramına ilişkin benzetmeler ise “olumlu yönleri,” “olumsuz yönleri” ve “hem olumlu hem de olumsuz” olarak üç kategoride toplanmıştır. Sonuç: Bu çalışma ameliyathanelerde çalışan hemşirelerin pandemide yaşadıkları zorlukların yansıra bu sürecin olumlu yönlerine de odaklandığını göstermektedir.
