TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4

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Now showing 1 - 20 of 83

Citation - WoS: 2
Citation - Scopus: 2
Adrenomedullin Has No Effect on Segmental Bone Defect Healing but Increases Bone Mineral Density in Rat Model
(AVES, 2023) Kaymakoğlu, Mehmet; Ciftci, E.; Korkusuz, P.; Ozdemir, E.; Erden, M.E.; Turhan, E.
Objective: This study aimed to investigate the effect of adrenomedullin on the healing of the segmental bone defect in a rat model. Methods: Thirty-six Wistar rats were randomly divided into 6 groups based on follow-up periods and administered a dose of adreno-medullin hormone. In each group, bilaterally, a 2-mm bone defect was created at the diaphysis of the radius. Sodium chloride solution was administered to sham groups 3 times a week for 4 and 8 weeks intraperitoneally. Adrenomedullin was administered to the study groups 3 times a week: 15 μg—4 weeks, 15 μg—8 weeks, 30 μg—4 weeks, and 30 μg—8 weeks, respectively. After euthanasia, the segmental defects were evaluated by histomorphometric [new bone area (NBA)] and microtomographic [bone volume (BV), bone surface (BS), and bone mineral density (BMD)] analyses. Results: Although the 4-and 8-week 15 μg administered study groups had higher NBA values than the other study and control groups, the histomorphometric analysis did not reveal any statistical difference between the control and study groups regarding NBA (P >.05). In microtomographic analysis, BV was higher in the 15 μg 4-week group than 30 μg 4-week group (296.9 vs. 208.5, P =.003), and BS was lower in the 30 μg 4-week group than in the 4-week control group (695.5 vs. 1334.7, P =.005), but overall, no significant difference was found between the control and study groups (P >.05). Despite these minor differences in histomorphometric and microtomographic criteria indicating new bone formation, the BMD values of the 15 μg 8-week study group showed a significant increase compared with the control group (P =.001, respectively). Conclusion: Adrenomedullin positively affected BMD at 15 μg, but this study could not show healing in the segmental defect site at different dose regimens. Further studies are needed to assess its effects on bone tissue trauma. © 2023, AVES. All rights reserved.
Citation - WoS: 1
Analysis of Joint Reliability Importance in Linear M-Consecutive L-Out System
(Ankara Univ, Fac Sci, 2020) Kan, Cihangir; Ozkut, Murat
Combinatorial techniques have an important role to compute the joint reliability importance (JRI) of some coherent systems. We obtain combi- natorial formula for calculation of the JRI of two components in a generalised version of consecutive type systems consisting of n linearly ordered components such that system fails if and only if (i§) there are at least m l-overlapping runs of k consecutive failed components (n m(k l) + l; l < k). Overlapping runs mean having common elements which is denoted by l: We concentrate on both s-independent & identical components and exchangeable components. Explicit combinatorial formulae are provided for computing the JRI of the above mentioned cases. For both cases, we also compare the results with lin- ear m-consecutive-k-out-of-n:F system (nonoverlapping case when l = 0). In addition, some numerical and illustrative examples are presented.
Citation - WoS: 14
Citation - Scopus: 12
Analysis of Risk Factors Affecting Mortality in Elderly Patients Operated on for Hip Fractures: a Retrospective Comparative Study
(Turkish Assoc Orthopaedics Traumatology, 2021) Biçen, Ahmet Çağdaş; Akdemir, Mehmet; Turken, Mehmet Aykut; Cekok, Kubra; Ekin, Ahmet; Turan, Ahmet Cemil
Objective: The aims of this study were (1) to investigate the effects of different demographic and perioperative modalities on mortality rates and (2) to compare mortality rates between different implants in elderly patients operated on for hip fractures. Methods: In this retrospective study, a total of 314 patients who were operated on for hip fractures were included study. Patients were then divided into four groups based in their implant types: long-stem cementless bipolar hemiarthroplasty (n = 124; 102 female, 22 male; mean age = 84.2 +/- 6.4 years), standard-stem cementless bipolar hemiarthroplasty (n = 74; 48 female, 26 male; mean age = 83.5 +/- 6.9 years), antegrade intertrochanteric nail (n = 61; 35 female, 26 male; mean age = 78.5 +/- 6.8 years), and total hip arthroplasty (n = 55; 34 female, 21 male; mean age = 72.5 +/- 4.3 years). Data including gender, age, duration from injury to surgery, American Society of Anesthesiologists (ASA) score, comorbidities, use of antiplatelet agents, Barthel Index of Activities of Daily Living, type of anesthesia, operation time, preoperative hemoglobin values, blood transfusions given, duration of hospital stay, complications, and type of fracture were recorded. Results: Overall, the mean follow-up was 36.5 (range = 0 - 107) months. The overall mortality rate was 53.2%. The median survival duration was 44.2 +/- 5 months (range = 34.3 - 54). Survival rates were found significantly different among the groups (P = 0.001). In the first three years postoperatively, the mortality rate was higher in the standard-stem bipolar hemiarthroplasty group, but in the long-term follow-up, the long-stem bipolar hemiarthroplasty group exhibited the higher mortality rates. It was observed that some parameters had statistically significant effects on the mortality rates. Male gender, higher age, lower hemoglobin values, increased number of blood transfusions, ASA scores >= 3, the existence of >= 3 comorbidities were found as main predictors of increased mortality rates. Conclusion: The results of this study have shown that age, gender, preoperative hemoglobin levels, ASA scores, and comorbidities are significant factors affecting mortality in elderly patients operated on for hip fractures. Long-stem cementless bipolar hemiarthroplasty appears to show similar rates of mortality with standard-stem cementless bipolar hemiarthroplasty.
Bakü-tiflis-ceyhan Boru Hattı Projesinin Hukuki Boyutları
(2012) Hekimoğlu, Mehmet Merdan
Kafkasya ve Orta Asya'daki zengin petrol ve doğal gaz yataklarının küreselleşen dünyadaki enerji ihtiyacının karşılanması için dünya pazarlarına sunulması, bölgedeki Türk devletlerinin ekonomik, sosyal ve siyasi gelişmelerinin sağlanması bakımından büyük bir önem taşımaktadır. Bakü-Tiflis-Ceyhan Boru Hattı projesi bu amacı gerçekleştirmeye yönelik ilk ciddi adımı meydana getirmektedir. Buna karşın söz konusu projenin hukuki çerçevesinin imzacı devletlerin lehine çizilebildiğini söylemek mümkün gözükmemektedir. Ancak büyük jeostratejik ve jeo-politik hedeflere ulaşılabilmesinin, bazen, sıra dışı hukuki yükümlülüklerle devletlerin kendilerini bağıtlamasını gerektirdiğinin de kabul edilmesi gerekir. Özellikle bölgede ilk defa böyle bir projenin gerçekleştirilecek olması, normal şartlar altında kabul edilmesi güç gözüken bir anormal hukuki yükümlülük rejimini doğallaştırmaktadır. Bununla birlikte, projenin hukuki temelini oluşturan "Transit Devlet Anlaşması" ile "Hükümetlerarası Anlaşmalar", uluslararası anlaşmalar hukukunca öngörülenin üzerinde bir sorumluluk rejimiyle imzacı devletleri uluslararası bir şirketler konsorsiyumuna karşı bağıtladığı için, bundan böyle yapılacak anlaşmaların hükümlerini hazırlarlarken bölge devletlerinin daha dengeli bir şekilde hareket etmeleri yerinde olacaktır.
BATIN BÖLGESİ ORGANLARININ MR GÖRÜNTÜLERİNDEN ÇOK AŞAMALI HİYERARŞİK SINIFLAMA İLE BÖLÜTLENMESİ
(2015) Kavur, Ali Emre; Dicle, Oğuz; Güzeliş, Cüneyt; Selver, M. Alper; Selvi, Eşref
Tıbbi görüntüleme ile anatomi hakkında ayrıntılı bilgi elde edinilebildiğinden, tanı amaçlı görüntüleme günümüzde birçok açıdan önem kazanmıştır. Görüntüleme cihazları tarafından sunulan verilerin fazlalığı ve çeşitliliği nedeniyle, tüm veri yerine görüntülerde sadece ilgilenilen dokunun belirlenerek ayrılması (Bölütlenmesi) sağlanabilir. Elcil yöntemler ile bölütleme yorucu, zaman alıcı ve deneyim gerektiren bir işlem olduğundan, otomatik yordamlara gereksinim duyulmaktadır. Geliştirilen yordamların klinik koşullarında kullanılabilmesi içinse yüksek başarıma sahip sonuçlar üretmeleri gerekmektedir. Manyetik Rezonans (MR) görüntülerinden batın bölgesindeki organlarının bölütlenmesi pek çok zorluk içeren bir uygulama alanıdır ve bu konudaki çalışmalar sınırlı sayıdadır. Batın bölgesinde yer alan, karaciğer, böbrekler, dalak, pankreas, safra kesesi gibi organların MR görüntüleri kullanılarak ileri seviye tıbbi analizi ve üç boyutlu incelenmesi pek çok tıbbi prosedür için mecburi olduğundan, bu çalışmada, ilgili organların bölütlenmesinde yukarıda belirtilen zorluklara karşı gürbüz, bölütlenecek organın özellikleri ve organların birbirleriyle olan ilişkilerini (konum vb.) göz önüne alan bir sistem geliştirilmiştir. Geliştirilen sistem farklı MR sekansları ile elde edilen görüntülere uygulanarak elde edilen sonuçlar tartışılmıştır.
Can Volumetric Magnetic Resonance Imaging Evaluations Be Helpful in the Follow-Up of Cognitive Functions in Cognitively Normal Parkinson's Disease Patients?
(Tubitak Scientific & Technological Research Council Turkey, 2024) Uysal, Hasan Armağan; Hunerli, Duygu; Çakmur, Raif; Dönmez Çolakoğlu, Beril; Ada, Emel; Yener, Görsev
Background/aim: In this study, besides the evaluation of gray and white matter changes in cognitively normal Parkinson's disease (PDCN) patients with volumetric magnetic resonance imaging (MRI) parameters, it was tried to show that some neuropsychological tests may be impaired in PD-CN patients. Materials and methods: Twenty-six PD-CN patients and 26 healthy elderly (HC) participants were included in the current study. Global cognitive status was assessed using the mini-mental state examination (MMSE), and the Montreal cognitive assessment scale (MoCA). Attention and executive functions were evaluated using the Wechsler memory scale-revised (WMS-R) digit span test and trail making test (TMT) part A and part B, the Stroop test, semantic and phonemic fluency tests, and clock drawing test. Magnetic resonance imaging (MRI) was acquired according to the Alzheimer's disease neuroimaging initiative (ADNI) protocol. Results: There were no significant differences among groups regarding age, sex, handedness, and years of education. In the comparison of the PD-CN group and the HC group, there was a statistical decrease in the total animal scores, lexical fluency, TMT part A and TMT part B scores in the PD-CN group. Subcortical gray matter volumes (GMV) were significantly lower in PD-CN patients. The PD-CN group had a significantly reduced total volume of right putamen and left angular gyrus compared to that in the HC group. We observed that putamen and angular gyrus volumes were lower in PD-CN patients. On the other hand, TMT part B may be a useful pretest in detecting the conversion of mild cognitive impairment in PD. Conclusion: Significant MRI volumetric measurements and neuropsychological test batteries can be helpful in the clinical follow-up in PD-CN patients.
Certainty Factor Model in Paraphrase Detection
(Pamukkale Univ, 2021) Metin, Senem Kumova; Karaoglan, Bahar; Kisla, Tarik; Soleymanzadeh, Katira
In this paper, we address the problem of uncertainty management in identification of paraphrase sentence pairs. Paraphrase sentences are simply sets/pairs of sentences that express the same facts and/or opinions using different words or order of words. We propose the use of certainty factor (CF) model in paraphrase detection. A set of succeeding paraphrase detection features (generic and distance based features) is built by filtering and this set is used as evidences in CF model. The CF model is evaluated by F1 and accuracy measures on Microsoft Research Paraphrase corpus. The results are compared to the well-known Bayesian reasoning. The experimental results showed that CF model is an alternating paraphrase detection method to Bayes model.
Citation - WoS: 15
Citation - Scopus: 14
Changes on Hepatitis C Virus Genotype Distribution in Western Turkey: Evaluation of Twelve-Year Data
(Aves, 2020) Duran, Alev Cetin; Cetinkaya, Ozgul Kaya; Sayiner, Ayca Arzu; Seydaoglu, Gulsah; Ozkaratas, Emre; Abacioglu, Hakan
Background/Aims: Hepatitis C virus (HCV) prevalence is 1% in Turkey with genotype 1 being the predominant type traditionally. However unique geographical location of Turkey and increasing human migration in the region influences the epidemiology of the infection. The aim of this study was to determine the changes in distribution of HCV genotypes and risk factors. Materials and Methods: In this retrospective single-center study, HCV genotyping results of 558 patients were evaluated in between 2005 and 2016.Three different HCV genotyping assays were used during the 12-year study period;restriction fragment length polymorphism (RFLP), Abbott Real Time HCV Genotype II and Bosphore HCV genotyping kit. Results: The most prevalent HCV genotype was genotype 1 detected in 88.4% of the patients followed by genotype 3 (5.2%),genotype 4 (2.9%),genotype 2 (2.1%), mixed genotypes (1.1%) and genotype 5 (0.3%). Genotype 1a showed an increasing prevalence. There were 19 patients (3.4%) either of foreign nationalities or Turkish citizens living abroad. Genotype 3 was the most common type among these patients which 10.3% had intravenous drug use history. Syrian migrant population differed in terms of HCV genotypes. Genotype 5 detected in two Syrian patients, which is the first report of HCV type 5 in Western Turkey. Among the HCV genotype 4 infected patients, 31.3% were Syrians. Conclusion: Our study showed that although genotype 1b dominance continues, the distribution and prevalence of HCV genotypes are changing in our region mainly due to migration and increase in the frequency of patients with non-traditional risk factors such as intravenous drug use. Monitoring the epidemiology of HCV genotypes may provide guidance in treatment decisions.
Citation - WoS: 9
Citation - Scopus: 9
Classical Heart Rate Variability and Non-Linear Heart Rate Analysis in Mice Under Na-Pentobarbital and Ketamine/Xylazine Anesthesia
(Tubitak Scientific & Technical Research Council Turkey, 2022) Kazdagli, Hasan; Ozel, Hasan Fehmi; Ozbek, Mustafa; Alpay, Suheda; Alenbey, Muruvvet
Background/aim: Anesthetics are often used in animal experiments to achieve immobilization and relieve pain. However, many anesthetics can alter the dynamics of cardiovascular systems. We aimed to compare the effects of two frequently used anesthetics agents on heart rate variability (HRV) parameters in mice. Materials and methods: This observational study was performed between May and June 2014 in 21 male BALB/c mice aged 16-20 weeks. The animals were divided into three groups: pentobarbital (P), (n = 7); pentobarbital+fentanyl (P+ F), (n = 7); and ketamine+xylazine (K+X), (n = 7). Surface electrocardiography (ECG) electrodes were placed in lead II configuration. 'the tachogram of RR intervals was obtained after R waves were detected using the Pan-Tompkins real-time QRS recognition algorithm. Frequency-domain, time-domain, and nonlinear HRV analyses were performed. Results: The bradycardia effect was higher in the K+X group (p < 0.01). Time-domain indices were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). Very low frequency (VLF) power was significantly lower in group K+X compared to group P and group P+F (p < 0.01). Low frequency (LF) power, low frequency/high frequency (LF/HF) ratio, and total power (TP) were higher in group K+X compared to group P (p < 0.01) and group P+F (p < 0.001). The detrended fluctuation analysis short-term parameter (DFA alpha(1)) was significantly higher in group K+X compared to group P+F (p < 0.05) and the long-term parameter (DFA alpha(2)) was lower in group K+X compared to group P (p < 0.05). Standard deviations SD1 and SD2 were higher in group K+X compared to group P (p < 0.001) and group P+F (p < 0.001), SD2/SD1 ratio was lower in group K+X compared to group P (p < 0.05) and group P+F (p < 0.05). Entropy measures did not differ between groups. Conclusion: HRV analyses, including nonlinear methods, indicated that a K+X combination reduces imbalance and disorder in the regulation of the autonomic nervous system (ANS) in comparison to both P and the P+F combination.
Classification of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines
(2023) Koçhan, Necla; Dayanç, Barış Emre
Background/aim: The molecular heterogeneity of colon cancer has made classification of tumors a requirement for effective treatment. One of the approaches for molecular subtyping of colon cancer patients is the consensus molecular subtypes (CMS), developed by the Colorectal Cancer Subtyping Consortium. CMS-specific RNA-Seq-dependent classification approaches are recent, with relatively low sensitivity and specificity. In this study, we aimed to classify patients into CMS groups using their RNA-seq profiles. Materials and methods: We first identified subtype-specific and survival-associated genes using the Fuzzy C-Means algorithm and log- rank test. We then classified patients using support vector machines with backward elimination methodology. Results: We optimized RNA-seq-based classification using 25 genes with a minimum classification error rate. In this study, we reported the classification performance using precision, sensitivity, specificity, false discovery rate, and balanced accuracy metrics. Conclusion: We present a gene list for colon cancer classification with minimum classification error rates and observed the lowest sensitivity but the highest specificity with CMS3-associated genes, which significantly differed due to the low number of patients in the clinic for this group.
A Convergent Algorithm for a Cascade Network of Multiplexed Dual Output Discrete Perceptrons for Linearly Nonseparable Classification
(Tubitak Scientific & Technical Research Council Turkey, 2014) Genc, Ibrahim; Guzelis, Cuneyt
In this paper a new discrete perceptron model is introduced. The model forms a cascade structure and it is capable of realizing an arbitrary classification task designed by a constructive learning algorithm. The main idea is to copy a discrete perceptron neuron's output to have a complementary dual output for the neuron, and then to select, by using a multiplexer, the true output, which might be 0 or 1 depending on the given input. Hence, the problem of realization of the desired output is transformed into the realization of the selector signal of the multiplexer. In the next step, the selector signal is taken as the desired output signal for the remaining part of the network. The repeated applications of the procedure render the problem into a linearly separable one and eliminate the necessity of using the selector signal in the last step of the algorithm. The proposed modification to the discrete perceptron brings universality with the expense of getting just a slight modification in hardware implementation.
A Copula-Based Classification Using Agglomerated Feature Selection_Extraction: An Application in Cervical Cancer Diagnostic
(Ankara University, Faculty of Science, 2025) Kochan, Necla; Sheikhi, Ayyub
The use of gene-expression datasets has significantly enhanced our understanding of complex diseases such as cancer. The importance of the relationship between genes in analyzing such datasets has been highlighted, indicating their crucial role in diagnosing the disease accurately. In this study, we investigate the associated copulas between attributes to extract fundamental block-related components. Subsequently, we perform a classification algorithm based on these components to classify a labeled target variable. Specifically, examining the practical implications and effectiveness of our approach in real-world scenarios, we provide a novel illustrative application in cervical cancer classification.
Citation - WoS: 32
Citation - Scopus: 32
Covid-19 Anxiety in People Living With Hiv: an Online Cross-Sectional Study
(Tubitak Scientific & Technical Research Council Turkey, 2020) Kuman Tuncel, Ozlem; Pullukcu, Husnu; Erdem, Huseyin Aytac; Kurtaran, Behice; Tasbakan, Selin Ece; Isikgoz Tasbakan, Meltem
Background/aim: The emergence of the coronavirus disease 2019 (COVID-19) outbreak has had an enormous emotional impact on sonic vulnerable groups, such as people living with human immunodeficiency virus (HIV) (PLHIV). This study was planned with the aim of assessing the anxiety levels of PLHIV and the sources of their anxiety. Materials and methods: A web-based questionnaire was sent to PLHIV using the virtual snowball sampling method. The questionnaire included questions about sociodemographic status, information about HIV infection, and the Beck Anxiety Inventory (BAI). Additionally, some opinions of the participants about COVID-19 were asked. Results: A total of 307 respondents, with a median age of 33 years, from 32 different cities, participated in the study. More than half of the respondents reported the belief that COVID-19 was not sufficiently well-known by the medical community and nearly 45% believed that they would have snore complications if they contracted COVID-19. One-fourth of the participants had anxiety. Having a preexisting psychiatric disorder, perceiving that they were practicing insufficient preventive measures, not being sure about the presence of any individuals with COVID-19 in their environment, and living with a household member with a chronic disease were found to be the risk factors of PLHIV for having anxiety during this pandemic. The BAI scores were correlated with the patient-reported anxiety levels about the spread of COVID-19 in Turkey, acquiring COVID-19, transmitting COVID-19 to another person, and transmitting HIV to another person. Among the stated conditions, the most common concern was the spread of COVID-19 all over the country, while the least common was transmitting HIV to someone else. Conclusion: The results revealed that a significant proportion of the sample had anxiety, and the findings were essential for developing evidence-based strategies for decreasing the anxiety of PLHIV, especially for those who had risk factors and to provide them with better health care during this pandemic or other pandemic-like crises.
Demansın Davranışsal ve Psikolojik Belirtileri Bilgi Ölçeği’nin Türkçe Versiyonunun (DDPB-T) Geçerliliği ve Güvenilirliği: Bakıcılar Arasında Psikometrik Bir Değerlendirme
(Turkiye Sinir ve Ruh Sagligi dernegi, 2024) Var, Levent; Güllüoğlu, Halil; Uysal, Hasan Armağan; Poyraz, Turan; Başaran, Simay; Eşkut, Neslihan
Amaç
Design and Analysis of Bi-Objective Flexible Job Shop Scheduling Problem: a Case Study in Construction Equipment Manufacturing Industry
(Pamukkale Univ, 2020) Resat, Hamdi Giray
This paper presents a design and development of mixed-integer linear optimization model for scheduling of flexible job-shop production problem under capacity constraints by using exact solution algorithm. Modelling approach is designed in order to introduce data analysis in real situations, minimize production time in production lines, reduce total production costs, and reveal important features of mathematical programming problem in detail. The main purpose of this study is to obtain faster and efficient Pareto solution sets for bi-objective problem by using epsilon-constraint method. Generated Pareto frontier using real life data is shared with decision makers. The GAMS programming language is used during the solution phase of a mixed-integer linear optimization model for bi-objective problem and production efficiency of the company is increased around 16.6% in terms of production cost.
Citation - WoS: 10
Citation - Scopus: 10
Design and Development of Hybrid Forecasting Model Using Artificial Neural Networks and Arima Methods for Sustainable Energy Management Systems: a Case Study in Tobacco Industry
(Gazi Univ, Fac Engineering Architecture, 2020) Resat, Hamdi Giray
This study presents a design and development of hybrid forecasting model by using ARIMA and artificial neural networks for short-term energy forecasting processes in energy management systems. Proposed model is applied into a company operating in the tobacco products manufacturing industry and reliability of the model is tested by using real-life data set in illustrative cases. In line with the results obtained from ARIMA method, some of the factors affecting electricity consumption are taken into consideration as input data for artificial neural network model. After considering the correlation between solar energy generation, working hours, production quantities and past electricity consumption data, various number of neurons and different training algorithms are tested to design the optimal system for the company. The proposed hybrid model provides around 39.9% improvement compared to forecast data obtained by using only ARIMA model.
Duchenne Muscular Dystrophy Patients Diagnosed at the Asymptomatic Stage: What Are the Benefits of Early Diagnosis
(Turkish Society of Physical Medicine and Rehabilitation, 2025) Sertpoyraz, Filiz Meryem; Tanigor, Goksel; Baydan, Figen; Kale, Murat Yildirim
Objectives: This study aimed to demonstrate whether a diagnosis given at the asymptomatic stage of patients with DMD can affect the clinical outcomes and to define the clinical characteristics of the patients. Patients and methods: The cross-sectional study was conducted with 136 male patients (mean age: 8.8±3.7 years; range, 3 to 17 years) with DMD between March 2022 and February 2023. The patients were diagnosed through clinical presentation, pathology studies, and genetic testing. The demographic, clinical, and the laboratory data of the patients were recorded. The patients were evaluated in two groups: those diagnosed at the asymptomatic stage due to elevated creatine kinase (CK) and those diagnosed due to clinical symptoms. Patients were further stratified according to their age groups: those younger than 10 years and those aged 10 years or older. Hand grip, quadriceps muscle strength, and Vignos and Brooke motor functional assessment scales of the two groups were compared. Results: In patients who were diagnosed with CK levels, CK elevation was significantly more common than other findings. When the age at diagnosis was evaluated, the age at diagnosis in those diagnosed with CK levels was statistically significantly lower than in those diagnosed with clinical findings. No significant difference was detected in clinical findings between the groups under the age of 10 years. Among patients aged 10 years or older, hand muscle strength, quadriceps muscle strength, and Vignos and Brooke motor function scale scores were significantly better in those diagnosed with CK levels compared to those diagnosed with clinical findings. Conclusion: This study shows that early diagnosis in the preclinical period, which enables earlier medical treatment and rehabilitation, may have a positive effect on motor functions and the course of the disease.
Citation - Scopus: 1
Effects of 1-(2 (trim) on Receptor-Independent And-Dependent Contractile Responses in Rat Aorta
(Tubitak Scientific & Technical Research Council Turkey, 2016) Selli, Cigdem; Erac, Yasemin; Tosun, Metiner
Background/aim: This study investigates whether 1-(2-trifluoromethylphenyl)-imidazole (TRIM), originally proposed as a nitric oxide synthase inhibitor and also suggested to be an inhibitor of store-operated calcium entry in mouse anococcygeal muscle, inhibits receptor-independent and -dependent responses in rat thoracic aorta. Materials and methods: Cyclopiazonic acid-and serotonin-induced vascular responses were investigated in aortic segments isolated from male Sprague Dawley rats using isolated tissue experiments. Changes in intracellular calcium levels were also monitored via front surface fluorescence measurements in fura-2-loaded embryonic rat vascular smooth muscle cell line A7r5. Results: TRIM inhibited serotonin-mediated vascular contractions without affecting cyclopiazonic acid-induced responses. In addition, TRIM caused a nonlinear rightward shift in the serotonin concentration-response curve, possibly via serotonin receptor modulation. Conclusion: TRIM may have an impact on investigation of tissue-specific receptor-independent and -dependent vascular responses. It may also be used as a lead compound in the development of selective serotonin receptor modulators.
Citation - WoS: 3
Citation - Scopus: 6
Effects of Bevacizumab Administration on the Hypoxia- Induced Pulmonary Hypertension Rat Model
(Tubitak Scientific & Technical Research Council Turkey, 2021) Demir, Canan; Karaman, Meral; Ucan, Eyup Sabri; Gokmen, Ali Necati; Gurel, Duygu; Coker, Sadiye Canan; Adali, Yasemen
Background/aim: Bevacizumab is a chemotherapeutic drug, which selectively binds to vascular endothelial growth factor (VEGF) and mainly inhibits angiogenesis and neovascularization. We aimed to study the possible effects of bevacizumab on right ventricular pressure (RVP), right ventricular hypertrophy, and VEGF, in hypoxia -induced pulmonary hypertension (PH) rat model. Materials and methods: 24 adult Wistar Albino rats were randomly divided into four groups: control group -saline; Bevacizumab Group; PH Group; PH + Bevacizumab Group. In hypoxia -induced model, 10% oxygen and 90% nitrogen were applied in a plexiglas box for eight days to PH Group and PH + Bevacizumab Group. On day eight, RVPs were measured directly from the heart, and then animals were sacrificed. Heart and lung tissues were examined, and Fulton index was measured. Results: RVP, Fulton index, and tissue VEGF scores were significantly lower in PH + Bevacizumab group than PH group: median (ranges), RVP, mmHg, 37.8 (33.0-39.0) and 32.3 (28.0-35.0), p: 0.01; Fulton index: 0.30 (0.29-0.33) and 0.25 (0.24-0.26), p: 0.003; tissue VEGF scores: 5.1 (4.8-5.3) and 4.0 (3.8 4.1), p: 0.004, respectively. Conclusion: Bevacizumab, which is indeed an antineoplastic agent, might have a favorable effect on hypoxia -induced pulmonary hypertension.
Citation - WoS: 2
Citation - Scopus: 3
Effects of Vertebral Fusion on Levels of Pro-Inflammatory and Catabolic Mediators in a Rabbit Model of Intervertebral Disc Degeneration
(Turkish Assoc Orthopaedics Traumatology, 2021) Dumanlidag, Davut; Keles, Didem; Oktay, Gulgun; Kosay, Can
Objective: The aim of this study was to explore the alterations in levels of pro-inflammatory and catabolic mediators following vertebral fusion in a rabbit model of intervertebral disc degeneration. Methods: In this study, 24 female New Zealand albino rabbits (aged 4 to 5 months and weighing 3 to 3.5 kg) were used. All the animals were randomly categorized into four groups, and dorsal spinal exposure of all lumbar vertebrae was routinely performed in each group. While disc degeneration was created in groups B, C, and D, spinal fusion was added to disc degeneration in groups C and D. Disc degeneration was typically created by puncturing the discs with an 18-gauge needle under the guidance of C-arm imaging. Fusion was achieved with posterior/posterolateral decortication and iliac bone grafts. The rabbits in groups A, B, and C were euthanized, and the discs were removed in the first week after the surgery. The rabbits in Group D were sacrificed, and the discs were harvested at 5 weeks after the surgery. The levels of Interleukin (IL)-1 beta, IL-6, Nitric Oxide (NO), Matrix Metalloproteinase (MMP)-3, MMP-13, and Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) in the discs were analyzed using enzyme-linked immunosorbent assay kits. Results: Significant increase was observed in the protein levels of both pro-inflammatory and catabolic mediators in disc degeneration groups (Group B, C, and D) compared to Group A. In the fusion groups (Group C and D), these increased mediators decreased, compared to non-fusion group (Group B), (IL1-beta P = 0.017, TIMP-1 P = 0.03, NO P = 0.03). However, there was no statistically significant difference in mediator levels between the short- and long-term fusion (Group C versus D). Conclusion: The results of this study have shown that a significant decrease in pro-inflammatory and catabolic mediators may be expected after vertebral fusion whereas there may be no significant difference between the first and fourth week of fusion surgery. These findings may contribute to clarifying the mechanism of action of vertebral fusion in the treatment of low back pain.

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