TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
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Article 1,25-Dihydroxyvitamin D3 Induces N-Myc Downstream Regulated Gene-2 Expression in Papillary Thyroid Carcinoma Cells(Dokuz Eylul Univ Inst Health Sciences, 2020) Sipahi, Murat; Bartik, Didem Keles; Doruk, Mehmet; Bayraktar, Firat; Oktay, GulgunPurpose: In addition to its role in serum calcium homeostasis, the anti-tumor function of 1,25-dihydroxyvitamin D-3 (calcitriol) in cancer development is well established. N-myc Downstream Regulated Gene 2 which functions as a tumor suppressor gene has recently been shown to be downregulated in various cancer leading to increased tumor incidence, progression and metastasis. The goal of this study was to investigate the possible effects of calcitriol treatment on NDRG2 expression in BCPAP papillary thyroid carcinoma cells. Methods: The experiments were carried on human primary thyroid follicular epithelial cells (Nthy-ori-3-1), and human papillary thyroid carcinoma cells (BCPAP). The half maximal inhibitory concentration (IC 50) of calcitriol on BCPAP cells was determined by WST-1 assay. BCPAP cells were treated with 15 and 30 mu M calcitriol for 24, 48, and 72 hours, respectively. Basal NDGR2 expression in Nthy-ori-3-1 and BCPAP cells as well as the alterations on NDRG2 expression in calcitriol treated BCPAP cells were evaluated with western blot. Results: A significant downregulation of NDRG2 was observed in BCPAP cells when compared to Nthy-ori-3-1 cells (p<0.01). IC50 dose of calcitriol was found to be 64, 54 and 43 mu M for 24, 48 and 72 hours, respectively. NDRG2 protein expression levels were significantly increased in 30 mu M calcitriol treated BCPAP cells after 48 hours (p<0.05). Conclusions: Calcitriol induced NDRG2 protein expression in BCPAP cells. We predict that calcitriol increased NDRG2 protein levels in BCPAP cells via c-Myc repression, which is upregulated by aberrant Wnt/beta-catenin signaling. Further investigation is required to enlighten the possible effect mechanisms of calcitriol in BCPAP cells.Article Citation - WoS: 1Citation - Scopus: 125-Hydroxyvitamin Levels in Sjögren’s Syndrome: Is It the Right Time to Dismiss the Case or Not(Walter de Gruyter GmbH, 2024) Sımsır, Ilgın Yıldırım; Tanigor, Goksel; Karabulut, Gonca; Barutcuoglu, Burcu; Yılmaz, ZevcetObjectives: This study aimed to investigate whether patients with primary Sjögren syndrome (SjS) have different levels of 25 OH-D3 (vitamin D) when compared to healthy populations and whether differences in 25 OH-D3 correlated with disease activity or markers. Methods: Eighty-eight female patients with SjS and 3,338 age-matched healthy female controls were included in this study. 25 OH-D3 levels were compared with healthy controls. Then the patients were stratified according to their 25 OH-D3 levels, either insufficient/deficient or normal (<50 nmol/L or ≥50 nmol/L). The disease activity was evaluated using The EULAR SjS disease activity index (ESSDAI) and its components. Correlation analyses were also performed for a possible correlation with disease characteristics and markers of activity. Results: No differences in 25 OH-D3 levels were found between SjS and healthy populations (p>0.05). No correla- tions were found between patient characteristics or labo- ratory values (p>0.05). Conclusions: This study did not find a link between disease characteristics and disease activity and 25 OH-D3 levels. Prospective studies with more patients should be conducted to reach a conclusion.Letter Citation - WoS: 1Citation - Scopus: 1About The Article Titled “a Different Scintigraphic Perspective On The Systolic Function Of The Left Ventricle-1” [“sol Ventrikül Sistolik Fonksiyonuna Sintigrafik Olarak Farklı Bir Bakış Açısı-1” Başlıklı Makale Hakkında](Galenos Publishing House, 2024) Taşçı, Cengiz[No abstract available]Article Aconitine Impedes Cell Motility in Mda-Mb Breast Cancer Cells(Dokuz Eylul Univ Inst Health Sciences, 2024) Keles, Didem; Sipahi, Murat; Surer, Seniz Inanc; Oktay, GulgunPurpose: Aconitine, a potent alkaloid from Aconitum plants, has shown promising anticancer properties. The aim of the study is to investigate the effects of aconitine on lateral migration, and matrix metalloproteinase (MMP) activity in MDA-MB-231 triple-negative breast cancer cells. Material and Methods: A WST-1 viability assay was conducted to determine the effect of aconitine on the viability of MDA-MB-231 cells. Following treatment with non-cytotoxic doses of aconitine, lateral migration was evaluated through wound healing assays. Additionally, gelatin zymography was conducted to analyze MMP-2 and MMP-9 activity and secretion levels. Results: Aconitine concentrations up to 200 mu M did not significantly affect cell viability for up to 72 hours, whereas higher doses (400-600 mu M) reduced viability in a time-dependent manner. Aconitine at 200 mu M showed a trend towards decreased lateral motility, with a significant reduction at 9 hours post-treatment. Gelatin zymography revealed no alterations in MMP-2 and MMP-9 activity or secretion levels following aconitine treatment. Conclusion: Aconitine demonstrates limited efficacy in modulating the migratory capacity of MDA-MB231 cells and does not affect gelatinase activity. Further investigation into underlying mechanisms is necessary, potentially leading to novel therapeutic strategies for triple-negative breast cancer.Article Citation - WoS: 6Citation - Scopus: 5Acrylamide-Encapsulated Glucose Oxidase Inhibits Breast Cancer Cell Viability(Walter De Gruyter Gmbh, 2020) Rrustemi, Trendelina; Geyik, Oyku Gonul; Ozkaya, Ali Burak; Ozturk, Taylan Kurtulus; Yuce, Zeynep; Kilinc, AliObjectives: Cancer cells modulate metabolic pathways to ensure continuity of energy, macromolecules and redoxhomeostasis. Although these vulnerabilities are often targeted individually, targeting all with an enzyme may prove a novel approach. However, therapeutic enzymes are prone to proteolytic degradation and neutralizing antibodies leading to a reduced half-life and effectiveness. We hypothesized that glucose oxidase (GOX) enzyme that catalyzes oxidation of glucose and production of hydrogen peroxide, may hit all these targets by depleting glucose; crippling anabolic pathways and producing reactive oxygen species (ROS); unbalancing redox homeostasis. Methods: We encapsulated GOX in an acrylamide layer and then performed activity assays in denaturizing settings to determine protection provided by encapsulation. Afterwards, we tested the effects of encapsulated (enGOX) and free (fGOX) enzyme on MCF-7 breast cancer cells. Results: GOX preserved 70% of its activity following encapsulation. When fGOX and enGOX treated with guanidinium chloride, fGOX lost approximately 72% of its activity, while enGOX only lost 30%. Both forms demonstrated remarkable resilience against degradation by proteinase K and inhibited viability of MCF-7 cells in an activity-dependent manner. Conclusions: Encapsulation provided protection to GOX against denaturation without reducing its activity, which would prolong half-life of the enzyme when administered intravenously.Article Citation - Scopus: 1Affecting Factors in Medication Adherence in Kidney Transplant Recipients(Aves, 2023) Ordin, Yaprak Sarigol; Karayurt, Ozgul; Ertan, Nermin; Edeer, Aylin Durmaz; Yildiz, SerkanObjective: This study aimed to determine the risk factors related to immunosuppressive medication adherence in kidney transplant recipients. Methods: The study adopted a retrospective design. It was carried out on 208 kidney transplant recipients. The social cognitive theory was used for understanding and addressing the issues of nonadherence to immunosuppressive medication. Data were collected with a self-reported-Immunosuppressant Therapy Adherence Scale and biological assays. Descriptive analyses and logistic regression were used to analyze data. Results: According to the self-reported assessment, medication adherence of the patients receiving transplants from live donors was 0.503 times lower than that of the patients receiving transplants from deceased donors. The biological assays did not show any affecting factors in medication adherence. Conclusion: The results of the study showed the importance of combining methods to assess medication adherence. In the self-reported assessment, live donor transplantation was found to negatively affect medication adherence. Turkiye is the country with the highest number of kidney transplantations from live donors in the world. Health professionals must be more careful in assessing medication adherence after live donor transplantations.Article Ageless Wisdom: a Cross-Cultural Study on Enhancing Life Satisfaction Through Skills Promotion Among Older Adults(2024) Adele Gaia De Stefani; Burçin Önder; Kaygın, Hüseyin; Ulus, İhsan Çağatay; Ratkowska-Pasikowska, Justyna; Ertürk, Nesrin OruçThis article explores the pervasive issue of ageism and its detrimental effects on the elderly population. Ageism or the prejudice and discrimination against older adults based on their age, can have significant impact on their well-being and life satisfaction. However, the article also delves into the potential positive effects of continuous learning on reducing ageism and enhancing the life satisfaction of the elderly. As a proactive approach, lifelong learning presents an opportunity for the elderly to challenge stereotypes, remain engaged in society, and foster personal growth. This study highlights how training and educational programs can empower older adults, instilling a sense of purpose and accomplishment, leading to a more fulfilled and satisfying life in their later years. The main purpose was to investigate how continuous learning affects the lives and life satisfaction perception of elderly people over the age of 65 from Greece, Hungary, Italy, Poland and Turkey after one week and 25 hours of technology, art and psychotherapy trainings that are believed to support them in every aspect of life.Article Aıds Bilgi ve Tutum Ölçeklerinin Geliştirilmesi ve Psikometrik Özelliklerinin Sınanması(2018) Arslan, Hatice Sevgi; Aydemir Çaylı, Nuran; Yakın, İbrahimBu çalışma, AIDS’e dair bilgi ve tutumları ölçmek için kullanılabilecek Türkiye’yehas iki ayrı ölçek geliştirmeyi ve bunları psikometrik açıdan değerlendirmeyihedeflemektedir. Bu amaçla, 37 maddelik bir bilgi ölçeği ve 23 maddelik birtutum ölçeği, İzmir’in farklı üniversitelerinde okuyan yaşları 17 ve üstü olan1025 öğrenciye kolay ulaşılabilir durum örneklemesi yöntemi kullanılarak testedilmiştir. Bilgi ölçeğinin madde ve faktör analizlerinden sonra ölçekten 16madde çıkarılmıştır. Oblik döndürme sonucu, varyansın %34’ünü açıklayanüç temel bileşen olduğunu göstermiştir. Bilgi ölçeğinin güvenirliğini sınamakiçin Kuder-Richardson-20 katsayısı hesaplanmış ve .76 olarak bulunmuştur.Tutum ölçeği için faktör analizi yapıldıktan sonra 6 madde çıkarılmıştır. Oblikdöndürme, varyansın %42.43’ünü açıklayan iki temel bileşeni ortaya çıkarmıştır.Ölçeğin Cronbach alfa değeri .90 olarak bulunmuştur. İki ölçek arasındaki ilişkiincelendiğinde ise, AIDS konusunda daha fazla bilgiye sahip kişilerin AIDS’ekarşı daha olumlu tutuma sahip olduğu gözlenmiştir. Özgün olarak geliştirilmiş 21maddeden oluşan AIDS Bilgi ve 17 maddeden oluşan AIDS Tutum ölçekleriningeçerlik ve güvenirliğine dair elde edilen bulgular, ölçeklerin ileride yapılacakaraştırmalarda kullanılmak için uygun olduklarını göstermektedir.Article Aile Hekimlerinin Sağlıklı Yaşam Biçimi Davranışlarının ve Klinik Uygulamalarında Yaşam Biçimi Tıbbının Değerlendirilmesi(Galenos Publishing House, 2025) Semin, Ilgi; Kazdağlı, Hasan; Gökdemir, ÖzdenAmaç: Bu çalışmanın amacı, aile hekimlerinin sağlıklı yaşam biçimi davranışlarını değerlendirmek ve klinik uygulamalarında yaşam biçimi tıbbına yönelik katılımlarını incelemektir. Yöntemler: Temmuz 2018 ile Ağustos 2019 tarihleri arasında aile hekimlerinden veri toplamak amacıyla çevrimiçi bir anket geliştirildi. Tanımlayıcı ve korelasyonel bir araştırma deseni kullanıldı. Çalışmada uygulanan anket, “katılımcıların kişisel bilgileri” ve “Sağlıklı Yaşam Biçimleri Davranış Ölçeği-II”i içermektedir. Kesitsel bir çalışma olarak tasarlanan bu araştırmada, örneklem kolayda örnekleme metodu ile sekiz ülkeden belirlenmiştir, ve anketler katılımcılara elektronik ortamda uygulanmıştır. Katılımcılara anketin süresi, veri saklama işlemleri, saklama süresi, araştırmacıların kimliği ve çalışmanın amacı hakkında bilgi verilmiştir. Bulgular: Çalışmaya 131 aile hekimi katılmış olup, erkek katılımcı oranı daha yüksek bulunmuştur. Sigara içme sıklığının Türk aile hekimleri arasında anlamlı derecede yüksek olduğu tespit edilmiştir (p=0,013). Ancak, ölçek toplam puanı veya altı boyutta alınan puanlar açısından aile hekimleri arasında istatistiksel olarak anlamlı bir fark bulunmamıştır. Sonuç: Çoğu aile hekimi, bu alanda daha fazla eğitim almak istediklerini belirtmiştir, bu da tıp fakültelerinin müfredatına eğitim müdahalelerin dahil edilmesi gerekliliğini göstermektedir. Ayrıca, iyi yapılandırılmış web tabanlı kitlesel çevrimiçi kurslar, aile hekimlerinin sağlıklı yaşam biçimi davranışları ve yaşam biçimi tıbbı uygulamalarına yönelik eğitim gereksinimlerini karşılamada etkili bir çözüm olabilir.Article Alternative E-Assessment in Language Classes: Recent Experiences and Future Directions(2024) Çağlayan, EsinThis study aimed to explore English as a Foreign Language (EFL) teachers' perceptions regarding alternative e-assessments in the Turkish tertiary level context. The study utilized semi-structured interviews with a sample of EFL instructors from 17 higher education institutions in Türkiye. The data were analyzed using thematic analysis to identify emerging themes. The results revealed varying perceptions about alternative e-assessments, with six primary themes emerging: impact on learning, workload, academic integrity, digital technology, grading and feedback, and assessment competence. Overall, this qualitative study provides valuable insights into the perceptions of EFL teachers regarding alternative e-assessments, highlighting key areas of concern. The study emphasizes the need to address these concerns in professional development programs that provide teachers with the necessary knowledge and skills to effectively implement alternative e-assessments. The results also have implications for the development of effective assessment policies and procedures, optimizing educational practices in the digital age.Article Alzheimer Hastaliği Klinik Olcutlerine Gore Demans ve Hafif Kognitif Bozukluk Ayriminda Sozel Akicilik Testlerinin Mini Mental Durum Testi ile Birlikte Kullanilmasi Yararli Olabilir(Cukurova Univ, Fac Medicine, 2022) Isbitiren, Yagmur Ozbek; Kiyi, Ilayda; Yener, GörsevPurpose: The aim of this study is to present the sensitivity, specificity and cut-off points of Mini Mental State Examination (MMSE), semantic and phonemic fluency tests determined by ROC curve analysis in differentiating between Alzheimer's dementia (AD) and mild cognitive impairment (MCI).Materials and Methods: Age-education-sex matched 72 healthy individuals, 72 MCI and 72 AD dementia individuals were included in the study. MMSE, semantic and phonemic fluency tests were applied to all participants. Sensitivity and specificity values and cut-off scores of MMSE, semantic and phonemic fluency tests in distinguishing healthy, MCI and ADD individuals were obtained by ROC curve analysis.Results: ROC analyses show that all three tests can significantly discriminate between healthy, ADD and MCI individuals. It was seen that the discrimination power of the MMSE was higher than the verbal fluency tests when the areas under the ROC curve were compared. The specificity of semantic fluency was found to be higher than MMSE and phonemic fluency in distinguishing individuals with ADD and MCI.Conclusion: The findings of the study show that MMSE is stronger than semantic and phonemic fluency in distinguishing healthy individuals, but its specificity is lower than semantic fluency in distinguishing MCI and AD dementia. In order to increase the diagnostic accuracy, it may be effective to add verbal fluency tests, especially semantic fluency test, which can be applied in a short time, to clinical practice.Article Citation - WoS: 2An Analysis of Factors Affecting Credit Scoring Performance in Smes(Ege Univ, Fac Economics & Admin Sciences, 2019) Saygili, Ebru; Saygılı, Arıkan Tarık; Isik, GokhanIn small and medium enterprises (SMEs), both financial and non-financial indicators related to the company and the large shareholder have significant effects on credit scores. This study explores the hybrid nature of SME credit scoring systems by developing an SME credit scoring model with general indicators, financial indicators and intelligence indicators related to the company and the major shareholder. This study is the first to explore the effect of intelligence indicators in credit scoring. It used regression analysis to evaluate real data from 125 SMEs operating in Turkey. Of 17 independent variables, 9 had statistically significant relationships with SME credit scores. The paper includes a comprehensive discussion of the implications of these findings.Article Citation - WoS: 2Citation - Scopus: 2Analysis of Nucleotide Changes in Rt-Pcr Primer/Probe Binding Regions in Sars-Cov Isolates Reported From Turkey(Ankara Microbiology Soc, 2021) Demir, Ayse Banu; Bulgurcu, Alihan; Appak, Ozgur; Sayiner, Ayca ArzuThe SARS-CoV-2 virus, which caused the COVID-19 epidemic, caused more than 55 million cases and nearly 1.5 million deaths worldwide. For the microbiological diagnosis of the disease, the most valid method is detecting the presence of the viral genome by real-time reverse transcription polymerase chain reaction (rRT-PCR). However, due to the nature of the RNA viruses, frequent mutations may affect the sensitivity of the analyses made on the genetic material of the virus, such as PCR. In this study, we aimed to investigate the mutations in the primer-probe binding regions of the rRT-PCR panels used in COVID-19 diagnosis. SARS-CoV-2 whole genome sequence data (n= 194) isolated from COVID-19 cases in Turkey and uploaded on GISAID database from the centers in Istanbul (n= 78), Ankara (n= 58), Kars (n= 47), Bursa (n= 2), Adiyaman (n= 2), Erciyes (n= 1) and Kocaeli (n= 1) between March 17-September 14, 2020 were analyzed. In order to determine the nucleotide changes, SARS-CoV-2 sequences from Turkey were compared to the reference genome sequence (NC_045512.1) present in GenBank website. The constructed data set was aligned using the MAFFT program and was checked manually if the sequences were in the same frame by using the AliView program. Primer-probe binding sites of the thirteen SARS-CoV-2 rRT-PCR panels from seven different institutes (US CDC, China CDC, Charite CDC, Pasteur, HKU, Thailand, NIID) that are being used in COVID-19 diagnosis were evaluated in terms of nucleotide changes within the corresponding regions compared to the reference genome. Sequence diversities in the viral genomes were determined via positional nucleotide numerical calculator and entropy calculator modules and nucleotide and entropy changes in primer-probe binding regions for each rRT-PCR panel were examined. Among thirteen different primer-probe panels, nucleotide changes in the target regions of the seven primer-probe panels were determined. When viral sequences with nucleotide changes in the primer-probe binding regions were examined, the most common changes were observed in the China CDC N-forward primer and US CDC N3-forward primer binding regions. It is important that the kits to be used as diagnostic tests are designed specific to the regions with less nucleotide changes. Nucleotide changes may not be critical for DNA amplification for most PCR panels, but should be carefully monitored as they may affect the sensitivity of the assay. If the risk of alteration of the designed region is high, the primer - probe binding sites should be checked frequently and updated when necessary.Other Analyzing the Dual Long Memory in Stock Market Returns(2011) Küçüközmen, C Coşkun; Ural, MertBu çalışmanın amacı, zayıf formda etkin piyasa hipotezi bağlamında birleşik ARFIMA-FIGARCH modeli ve yapısal kırılma testi kullanarak beş farklı borsa endeks getiri serisi için ikili uzun hafıza özelliklerini incelemektir. Modeller S&P500, FTSE100, DAX, CAC40 ve ISE100 borsa endekslerinin günlük kapanış fiyatları kullanılarak test edilmiştir. Volatilite sürekliliği üzerinde yapısal kırılmaların etkilerini belirlemek üzere ICSS (Iterative Cumulative Sums of Squares) algoritması ile varyanstaki kırılmalar tespit edilmiş ve modellere kukla değişkenler olarak eklenmiştir. Analiz sonuçlarına göre, tüm borsalar için ikili uzun hafızanın bulunduğu anlaşılmıştır. Ayrıca volatilitenin öngörülebilir yapı göstermesi nedeniyle tüm borsaların zayıf formda etkinsiz oldukları sonucuna varılmıştır. Bunun yanı sıra, varyanstaki yapısal kırılmaların modellere eklenmesiyle volatilite dinamiklerinin daha doğru hesaplandığı ve volatilite sürekliliğinin fiilen azaldığı saptanmıştırArticle Anksiyete Düzeyleri Açısından Boşanmış ve Evli Anneler ile Çocuklarının İncelenmesi(2011) Gregory, Nilgün ÖngiderAmaç: Bu araştırmada, boşanmanın çocuk üzerindeki etkilerinin incelenmesi amacı ile, boşanmış ve evli ailelerden gelen anneler ve onların çocuklarının anksiyete düzeyleri karşılaştırılmıştır.Yöntemler: Araştırmanın örneklemi, İzmir ilindeki bir ilköğretim okuluna devam eden anne-babası boşanmış ve evli olan 3-6. sınıf öğrencileri ve onların annelerinden oluşmaktadır. Araştırmaya katılan çocuklara, Çocuklar İçin Durumluk ve Sürekli Anksiyete Ölçeği ile Bireysel Bilgi Formu; annelere ise, STAI ve Bireysel Bilgi Formu uygulanmıştır.Bulgular: Anne-babası boşanmış olan çocukların durumluk ve sürekli anksiyete düzeylerinin, anne-babası evli olan çocuklara göre daha yüksek olduğu (t=4.13 p<0.05, t=5.08 p<0.05) bulunmuştur. Benzer şekilde, boşanmış annelerin durumluk ve sürekli anksiyete düzeylerinin, evli annelere göre daha yüksek olduğu da (t=5.76 p<0.05, t=6.31 p<0.01) bulunmuştur. Sonuç: Anne-babası boşanmış olan çocukların ve bu çocukların annelerinin anksiyete düzeylerinin anne-babası evli olan çocuklara ve bunların annelerine göre yüksek bulunması, boşanmanın hem çocuklar hem de anneleri üzerinde olumsuz etkilere neden olduğunu düşündürmektedir.Article An Anthropomorphistic Approach To Measuring Civil Society Organization's Reputation: a Semantic Network Analysis(Marmara Univ, Fac Communication, 2018) Turkel, SelinThe aim of the study is to reveal common meaning of reputation and disreputableness for civil society organizations (CSOs) by utilizing anthropomorphism. Accordingly, 212 individuals living in Izmir were asked to personify the CSOs they deemed reputable and disreputable, and provide adjectives that best described CSOs. In this study which was designed as descriptive research, semantic network analysis was employed and reputable and disreputable networks were visualized using a social network analysis software named Pajek. The relational analysis was performed using the measures of m-core, clique, articulation point, in-out degree, in-out closeness and betweenness. The first study to uncover the shared meaning of the CSO's reputation adopting the anthropomorphism approach reveals both positive and negative personality traits such as being helpful, honest, reliable and self-seeking, trickster, liar, and untrustworthy. The results of the research can contribute to the development of an appropriate measure of CSO's reputation for Turkish society.Article Citation - WoS: 1Antioxidant and Prooxidant Properties of Selected Herbs and Citrus Bergamia Risso Et Poiteau (bergamot) Used for the Management of Hyperlipidemia(Istanbul Univ, Fac Pharmacy, 2022) Akyildiz, Zehra Ilke; Kose, Fadime Aydin; Somer, Nehir UnverBackground and Aims: In recent years, there has been an increased interest in the search for herbs to aid the management of hyperlipidemia. There is currently very little data on the simultaneous evaluation of the antioxidant and prooxidant properties of antihyperlipidemic herbs. This study was designed to evaluate the antioxidant and prooxidant properties of four antihyperlipidemic herbal drugs and also of bergamot. Methods: Antioxidant property was determined by ferric ions (Fe3+) reducing capacity (IRC), DPPH radical scavenging activity (DPPH IC50) and trolox equivalent antioxidant capacity (TEAC); deoxyribose degradation test was used for prooxidant property. Results: The highest total phenolic content (TPC) was in the myrtle leaf (ML)(135.35 +/- 3.46 mg GAE/g, p<0.05) whereas the highest total flavonoid content (TFC) was in green tea (GT) (48.76 +/- 0.69 mg QE/g, p<0.05) both of which were maintained from a pharmacy. Among the bergamot samples, the highest TPC and TFC values were in filtered fruit juice (BFFJ) as 197.35 +/- 6.29 mg GAE/100 mL; and 94.14 +/- 1.39 mg QE/100 mL; p<0.05, respectively. GT showed the highest antioxidant capacity in IRC and TEAC assays (2.29 +/- 0.12 mM TE/g; and 2.32 +/- 0.07 mmol TE/mg, p<0.05). The lowest DPPH IC50 was identified in ML from a pharmacy (6.95 +/- 0.08 mu g/mL; p<0.01). BFFJ had the highest IRC (2.94 +/- 0.031 mM TE/10 mu L), TEAC (5.14 +/- 0.084 mmol TE/10 mu L) and the lowest DPPH IC50 value (10.561 +/- 0.17 mu L). GT from a pharmacy and 1mg/mL concentration BFLFJ (filtered and lyophilized) were associated with the lowest hydroxyl radical scavenger activity (0.171 +/- 0.013 mu M MDA equivalent, p<0.05 and 0.144 +/- 0.015 mu M MDA equivalent, p<0.05). Conclusion: BFLFJ and GT got the highest attention due to high TPC, TFC, antioxidant and low prooxidant properties. Our results highlight the necessity of clarifying the value of bergamot and GT in this field with further studies.Article Assessing Service-Learning Approach: Semantic Meanings of Learning Outcomes and Student Experiences(2021) Türkel, Selin; Uzunoğlu, Ebru; Ünsal, Pınar UmulThis study uncovers existing practices of service-learning (SL) in higher education institutions. This was achieved by an examination of 64 courses in Turkish universities with accessible learning outcomes. The study also incorporates a “best practice” case study, a communication campaign combatting hate speech against refugee children. A comparison was made of general learning outcomes and individual and community outcomes reported by 43 students enrolled in the course in which the campaign was executed. Both text-based learning outcomes and student interview data were subject to semantic network analysis. SL courses in general display a strong emphasis on learning through projects, but the case study results indicated an absence of important outcomes such as engagement and citizenship values. In other respects, these courses not only aimed at significant learning outcomes in cognitive and affective domains, but also at assisting the transfer of necessary communication skills. The study presents insights for development of higher education curricula and implications for further research.Article An Assessment of Menstrual and Genital Hygiene Behaviours Among Adolescent Females at Gazimagusa, Northern Cyprus(Marmara Univ, Inst Health Sciences, 2022) Mamuk, Rojjin; Parlan, Hasret; Asif, Eren; Deveci, Muruvvet; Akdeniz, EbruObjective: Inadequate menstrual and genital hygiene behaviours are common and important problems for adolescent health. This study aims to determine menstrual and genital hygiene behaviours and the affecting factors among female students enrolled in high schools located in Gazimagusa, Northern Cyprus. Methods: This school-based, cross-sectional, and descriptive study was conducted in three high schools in the Gazimagusa town borders in Northern Cyprus with 379 students. Data were collected through the Socio-demographic Form and the Genital Hygiene Behaviours Scale. Results: The scale mean score was found 79,28 +/- 6,80 (min:47 / max: 112). The factors affecting menstrual and genital hygiene behaviours were found to be the type of schools the students were enrolled (X2: 14,771 / P: 0,001), the education level of the mothers (X2: 9,806 / P: 0,020), and the education level of the fathers (X2: 15,879 / P:0,001). Conclusions: The participants of this study had an above-average level of right genital hygiene behaviours. Genital hygiene behaviours were found to be affected by the type of school, the education level of the mothers, and the education level of the fathers.Article Avrupa Yeşil Mutabakatının Etkilerinin Çerçevelendirilmesi: “normatif Güç” Olarak Ab ve Ötesine Yansımaları(2024) Biresselioğlu, Mehmet Efe; Solak, Berfu; Savaş, Zehra FundaFosil yakıtların artan kullanımı ve sera gazı emisyonları dünya siyasetinde kritik konular haline gelmiştir. Avrupa Birliği (AB) Yeşil Mutabakatı, Avrupa'yı 2050 yılına kadar \"ilk iklim nötr kıta\" haline getirmeyi taahhüt etmektedir. Yeşil Mutabakat, AB'yi kaynak verimli, rekabetçi ve döngüsel bir ekonomiye dönüştürmeyi amaçlamaktadır. Uluslararası politikada normatif bir güç olarak AB, diğer aktörlerin davranışlarını etkileyebilmekte ve bu da AB’yi uluslararası bir norm yayıcı konumuna getirmektedir. Bu anlamda, \"normatif güç Avrupa\" kavramı Yeşil Mutabakatın rolüyle örtüşmektedir. Bu makale, AB Yeşil Mutabakatının karbon nötrlüğü sürecinde AB'nin normatif bir güç olarak rolünü sürdürmek için başarılı bir araç olup olmadığını incelemekte ve AB Yeşil Mutabakatının fırsatlarını ve zorluklarını ele almaktadır.
