Emirdar, Volkan

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https://hdl.handle.net/20.500.14365/6939
Name Variants
Emirdar, V.
Emirdar, Volkan
Job Title
Email Address
volkan.emirdar@ieu.edu.tr
Main Affiliation
09.04. Surgical Sciences
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Current Staff
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ORCID ID
0000-0003-4973-2563
Scopus Author ID
36162768400
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Google Scholar ID
HPix3kgAAAAJ
WoS Researcher ID
AGZ-8238-2022

Sustainable Development Goals

NO POVERTY1
NO POVERTY
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ZERO HUNGER2
ZERO HUNGER
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GOOD HEALTH AND WELL-BEING3
GOOD HEALTH AND WELL-BEING
2
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QUALITY EDUCATION4
QUALITY EDUCATION
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GENDER EQUALITY5
GENDER EQUALITY
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CLEAN WATER AND SANITATION6
CLEAN WATER AND SANITATION
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AFFORDABLE AND CLEAN ENERGY7
AFFORDABLE AND CLEAN ENERGY
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DECENT WORK AND ECONOMIC GROWTH8
DECENT WORK AND ECONOMIC GROWTH
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INDUSTRY, INNOVATION AND INFRASTRUCTURE9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
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REDUCED INEQUALITIES10
REDUCED INEQUALITIES
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SUSTAINABLE CITIES AND COMMUNITIES11
SUSTAINABLE CITIES AND COMMUNITIES
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RESPONSIBLE CONSUMPTION AND PRODUCTION12
RESPONSIBLE CONSUMPTION AND PRODUCTION
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CLIMATE ACTION13
CLIMATE ACTION
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LIFE BELOW WATER14
LIFE BELOW WATER
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LIFE ON LAND15
LIFE ON LAND
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PEACE, JUSTICE AND STRONG INSTITUTIONS16
PEACE, JUSTICE AND STRONG INSTITUTIONS
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PARTNERSHIPS FOR THE GOALS17
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17

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335

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20

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290

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Scholarly Output

15

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11

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67/114

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WoS Citation Count

24

Scopus Citation Count

28

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WoS Citations per Publication

1.60

Scopus Citations per Publication

1.87

Open Access Source

7

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JournalCount
Fertılıty And Sterılıty3
Bıomed Research Internatıonal1
Ege Klinikleri Tıp Dergisi1
Ege Tıp Dergisi1
Human Reproduction1
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Now showing 1 - 10 of 15
  • Thumbnail Image
    Article
    Metabolomic Signatures in Blastocyst Spent Culture Medium as Non-Invasive Predictors of Live Birth: A Pilot Study
    (Elsevier Sci Ltd, 2026) Emirdar, Volkan; Gode, Funda; Taskin, Ayse Buket; Pala, Ibrahim; Secinti, Beren Su; Madran, Selin
    Research question: Can metabolomic profiling of blastocyst spent culture medium (SCM) serve as a non-invasive tool to predict live birth? Design: This pilot study investigated the association between metabolite profiles in SCM and clinical outcomes following single blastocyst transfer. Seventy SCM samples were analysed using untargeted liquid chromatography-mass spectrometry. Metabolites were identified via Human Metabolome Database and Compound Discoverer 3.3. Statistical analyses were performed using SPSS. Results: In total, 173 metabolites were detected in SCM samples. Six metabolites exhibited significant differences between the pregnancy and non-pregnancy groups, while 10 metabolites varied between the live birth and non-live birth groups. Notably, eicosapentaenoic acid, a polyunsaturated fatty acid, decreased in pregnancy cases. In contrast, 1-(4-methoxyphenyl)-3-pentanone and (2S)-2-(6-methoxynaphthalen-2-yl) propanoic acid were consistently elevated in both the pregnancy and live birth groups. Additional differential metabolites included L-glutamine, pyroglutamylglycine, alanylproline and 15,16-dihydroxyoctadecanoic acid, potentially reflecting implantation-related metabolic activity. Logistic regression and receiver operating characteristic curve analyses demonstrated acceptable predictive performance, with area under the curve values of 0.788 for pregnancy and 0.834 for live birth. Conclusions: Metabolomic profiling of SCM may offer a promising non-invasive adjunct to embryo selection strategies. While these findings suggest biological relevance of several metabolites, particularly lipids and amino acid derivatives, larger studies are needed to validate predictive value and clinical applicability.
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    Conference Object
    Transferring Single Thawed Cleavage Stage Embryo at Blastocyst Stage Is Al' Least Successful as 'transferring Single Thawed Blastocyst in Terms of Art Cycle Outcome
    (Elsevier Science Inc, 2022) Isik, Ahmet Zeki; Colak, Eser; Gode, Funda; Tamer, Burcu; Isik, Merve; Emirdar, Volkan
    [Abstract Not Available]
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    Article
    İNTRASİTOPLAZMİK SPERM İNJEKSİYONU YAPILAN HASTALARDA DONDURMA ÇÖZME SİKLUSLARINDA 5. GÜN VE 6. GÜN EMBRİYO TRANSFER SONUÇLARININ KARŞILAŞTIRILMASI
    (2021) Pala, İbrahim; Doğan, Selda Bahar; Karataşlı, Volkan; Göde, Funda; Işık, Ahmet Zeki; Tamer, Burcu; Emirdar, Volkan
    Giriş: Bu çalışmanın amacı intrasitoplazmik sperm enjeksiyonu yapılan hastalarda dondurma çözme sikluslarında 5. gün ve 6. gün embriyo transfer sonuçlarının karşılaştırılmasıdır. Gereç ve Yöntem: 2017-2019 yılları arasında İzmir Medikalpark Hastanesi Tüp Bebek Ünitesi’nde yapılan dondurma çözme siklusları arasında 5.(Grup 1) ve 6. gün (Grup 2) embriyo transferi yapılan hastaların dosyaları retrospektif olarak incelendi. Çalışmaya 40 yaş altında olan ve tek embriyo transferi yapılan kadın olgular dahil edildi. İki grubun klinik özellikleri, gebelik ve klinik gebelik sonuçları karşılaştırıldı. İstatistiksel analizde ortalamaları karşılaştımada t-test ve oranları karşılaştırmada ki-kare testleri kullanıldı. p<0.05 istatiksel anlamlı kabul edildi. Bulgular: Çalışmaya toplam 333 hasta dahil edildi. İki yüz doksan dört hastaya 5. gün (Grup 1), 39 hastaya ise 6. gün (Grup 2) dondurma çözme transferi uygulandı. Olguların genel klinik özelliklerine bakıldığında yaş (30.0?4.6; 31.4?4.3), infertilite süresi (4.0?2.8; 4.7?2.9), önceki siklus sayısı (2.8?1.7; 3.4?1.8), elde edilen oosit sayısı (11.3?4.6; 11.9?7.2) ve elde edilen embriyo sayısı (7.3?3.2; 7.0?4.7) açısından istatistiksel anlamlı bir farklılık saptanmadı. Hastaların gebelik sonuçlarına bakıldığında ise Grup 1’de %62.2 (183/294), Grup 2’de ise %33.3 (10/39) gebelik elde edildiği saptandı (p<0.05). Klinik gebelik sonuçları incelendiğinde Grup 1’de %49.2 (183/264), Grup 2’de ise %17.9 (7/39) klinik gebelik elde edildiği görüldü (p<0.05). Sonuç: Dondurma çözme sikluslarında 6. gün embriyo transferi gebelik ve klinik gebelik oranları 5. gün embriyo transferine göre daha düşüktür.
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    Article
    Citation - WoS: 3
    Citation - Scopus: 3
    In Vitro Fertilization and Preimplantation Genetic Diagnosis Outcomes in Mosaic Turner's Syndrome: a Retrospective Cohort Study From a Single Referral Center Experience
    (Elsevier Masson, Corp Off, 2022-09) Acet, Ferruh; Sahin, Gulnaz; Ucar, Abdullah Ali Osman; Emirdar, Volkan; Karaca, Emin; Durmaz, Burak; Goker, Ege Nazan Tavmergen; Tavmergen, Erol
    Background: : Patients with mosaic Turner syndrome who have normal phenotype and pubertal development may be diagnosed based on karyotype examination which is performed due to recurrent abortion or recurrent implantation failure; but according to the literature review, reproductive and obstetric consequences of these cases are based on case reports. There are contradictory publications on this subject recommending pre-implantation genetic testing (PGT) may be a solution to reduce the high risk for the fetus and perform normal embryo transfer. Aim: : In this study, our aim was to evaluate the results of in vitro fertilization and preimplantation genetic diagnosis in patients with low-grade and high-grade mosaic Turner syndrome. Methods: : We collected data of patients between 2012 and 2018 from a single center retrospectively. The study analyzed 36 mosaic Turner syndrome patients, of whom, 10 patients were evaluated as high, 26 patients were evaluated as low-grade mosaic pattern for Turner syndrome. Results: : Mean age (35,46 +/- 0,87 vs. 36,2 +/- 1,85) body mass index (25,26 +/- 0,74 vs. 30,8 +/- 0,63) baseline follicle stimulating hormone (5,73 +/- 0,74 vs. 6,70 +/- 1,17) basal luteinizing hormone (4,78 +/- 0,43 vs. 4,92 +/- 0,99) were similar between two groups. In the high-grade mosaic Turner Syndrome patients, duration of stimulation (7,60 +/- 0,16 vs. 8,0 +/- 0,28, p < 0,001), total gonadotrophin dose (1540,0 +/- 165,12 vs. 2046,15 +/- 111,47, p < 0,001) and the number of normal karyotype embryos was statistically significantly higher (1,58 +/- 0,17 vs. 2,0 0 +/- 0,55, p < 0,0 01). The Pregnancy rates in the low-grade and high-grade mosaic Turner syndrome patients' cycles were 30,8% versus 30%, ( p = 0.76) respectively. IVF results were also evaluated by the presence of triploidy were accompanying Turner syndrome or not. In the presence of one or 2 X chromosomes, none of the included in the study could achieve live birth. The most common abnormality in the embryos was monosomy and trisomy of the chromosome13. In 30% of the cases, there were 2 or 3 abnormalities present together. In embryos with 2 abnormal chromosomes, the most common 2 abnormalities were monosomy 13 and trisomy 21, while trisomy 13, trisomy X and monosomy 18 were found in 3 or more abnormalities, respectively. Conclusion: : In vitro fertilization and Preimplantation genetic diagnose should be considered in the infertility treatment of the patient with mosaic Turner Syndrome. (c) 2022 Elsevier Masson SAS. All rights reserved.
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    Article
    Fertilite Prezervasyonu Sonuçlarını Öngörmede Antimüllerian Hormon ve Antral Follikül Sayısının Yeri, Retrospektif Tarama
    (2022) Acet, Ferruh; Emirdar, Volkan
    Amaç Fertilite prezervasyon ( siklusu sonuçlarını tahmin etmek için henüz uygun bir strateji belirlenmemiştir Amacımız, letrozol ve gonadotropinler ( ile gerçekleştirilen kontrollü ovaryan stimülasyona yanıt olarak elde edilecek oosit sayısı tahmininde anti müllerian hormon AMH) ölçümleri ve antral folikül sayılarının ( değerini belirlemekti Gereç ve yöntem Oosit ve/veya embriyo kriyoprezervasyonu için letrozol ve gonadotropinlerin kombine protokolü ile over stimülasyonu uygulanan meme kanserli yüz elli iki kadın hastanın verileri geriye dönük olarak tarandı Siklusun ilk 3 gününde serum AMH ölçümü ve ultrasonografi ile AFC sayımı yapıldı 4 oosit veya 2 embriyo elde edilen hastalar düşük yanıtlı olarak kabul edildi Bulgular Hastaların yaş ortalaması 34 9 4 5 idi AMH, elde edilen oosit sayısı ve dondurularak saklanan embriyo sayısını öngörmede AFC'den daha iyi korelasyon gösterdi (oosit sayısı için r= 0 625 p< 0 001 vs r= 0 38 p< 0 001 ve embriyo sayısı için r= 0 422 p< 0 001 vs r= 0 280 p< 0 001 ROC eğrisi analizi sonuçlarında, AMH ve AFC normal yanıtlı hasta grubunda elde edilen oosit sayısını (AMH AUC= 0 896 ve AFC= 0 815 p= 0 223 ve elde edilen embriyo sayısını (AMH için AUC= 0 847 ve AFC= 0 721 p= 0 143 öngörmede benzerdi AMH cut off 1 1 kabul edildiğinde, düşük ovaryen yanıt için pozitif ( ve negatif prediktif değerler ( sırasıyla 100 ve 20 2 idi AFC< 6 için PPV ve NPV sırasıyla 90 9 ve 50 idi Sonuç AMH, AFC’ye göre meme kanseri tanısı alan,letrozol ve gonadotropin ile fertilite prezervasyonu uygulanacak hastalarda düşük ovaryen yanıtı öngörmede daha güçlü bir belirteçtir Bu sonuç, kemoterapi öncesi oosit veya embriyo kriyoprezervasyonu uygulanan kadınlara rehberlik etmede faydalı olabilir
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    Conference Object
    The Effect of Standart Icsi and Picsi on Pgta Results During Ivf Cycles
    (Elsevier Science Inc, 2022) Gode, Funda; Emirdar, Volkan; Pala, Ibrahim, Sr.; Isik, Ahmet Zeki
    [Abstract Not Available]
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    Article
    Citation - WoS: 8
    Citation - Scopus: 8
    The Effect of Azoospermia Factor Microdeletions on Intracytoplasmic Sperm Injection Results in Azoospermia Patients
    (Professional Medical Publications, 2023-03-25) Emirdar, Volkan; Acet, Ferruh
    Background & Objective: Y chromosome abnormalities are common in male patients with severe oligo-azoospermia. In studies with karyotype analysis and cytogenetic methods, the importance of the Y chromosome in spermatogenesis has been well understood. Deletions in the azoospermia factor (AZF) localized at the distal end of the Y chromosome adversely affect the spermatogenesis process. Our objective was to determine the frequency of AZF microdeletion in azoospermia patients who underwent microTESE.Methods: In this retrospective cohort study, 806 azoospermic men attending the In Vitro Fertilization (IVF) Center for infertility treatment between 2010 and 2022 were included. AZF deletion screening was conducted in all patients included in the study. Azoospermic patients with and without Y microdeletion were matched with the female's age, cause of infertility, number of oocytes retrieved and number of metaphase II (MII) oocytes produced and compared. The primary outcome was the live birth rate (LBR). Pregnancy rate (PR) and clinical pregnancy rates (CPR) were secondary outcomes.Results: We detected Y microdeletion in 55 (6.82%) of 806 infertile azoospermic men and 35 of them included in the study. Although the required gonadotropin dose and the total number of retrieved oocytes were similar, clinical pregnancy rates and live birth rates were found to be significantly lower in the microdeletion patient group (21.6% vs. 43%, p<0.05; and 18.9% vs. 36%, p<0.05, respectively).Conclusions: Poor sperm quality in AZF microdeletion patients complicates the selection of appropriate sperm for ICSI. Therefore, it leads to a decrease in embryonic development, fertilization and pregnancy results. In order to select the best sperm for the use in ICSI procedure in this patient population, intracytoplasmic morphologically selected sperm injection (IMSI) method can be preferred to improve the cycle outcomes.
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    Conference Object
    Blastocyst Spent Culture Medium Metabolite Levels and Reproductive Outcomes
    (Oxford univ press, 2024) Funda, G.; Pala, I.; Emirdar, V.; Secinti, B. S.; Taskin, A. B.
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    Article
    Metabolomic Signatures in Blastocyst Spent Culture Medium as Non-Invasive Predictors of Live Birth: A Pilot Study
    (Elsevier Ltd, 2026-06) Emirdar, Volkan; Göde, Funda; Taşkin, Ayşe Buket; Pala, Ibrahim; Seçinti, Beren Su; Madran, Selin
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    Article
    Citation - WoS: 9
    Citation - Scopus: 12
    Comparison of the Effects of Total Laparoscopic Hysterectomy and Total Abdominal Hysterectomy on Sexual Function and Quality of Life
    (Hindawi Ltd, 2020-01) Beyan, Emrah; Inan, Abdurrahman H.; Emirdar, Volkan; Budak, Adnan; Tutar, Sadettin O.; Kanmaz, Ahkam G.
    It is known that benign gynecological diseases negatively affect sexual function. For this reason, hysterectomy provides improvement in sexual function as well as symptoms such as bleeding and pain. The effects of abdominal hysterectomy (TAH) and laparoscopic hysterectomy (TLH), which are the two most common types of hysterectomy today, are not clear. In our study, we investigated the effects of TAH and TLH on sexual function and quality of life as well as intraoperative and postoperative results. In 329 TLH and 126 TAH patients, we compared both and between themselves preoperatively and postoperatively by using the standardized and validated female sexual function index (FSFI) and European quality of life five-dimension scale (EQ-5D). In conclusion, we found that both types of hysterectomy were effective in improving sexual function, and we concluded that improvement in the laparoscopy group was statistically higher. Patients who require hysterectomy for benign gynecological reasons should be informed that TLH has a more positive effect on sexual function as well as other advantages, and if the patients' main complaint is sexual dysfunction, TLH should be preferred compared to TAH.