TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Permanent URI for this collectionhttps://hdl.handle.net/20.500.14365/4

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24 Saatlik İdrarda Protein Atılımının Tanılayıcı Kullanımı ve Advers Perinatal Sonuçlar ile Doğum Zamanı için Protein-kreatinin Oranı
(2021) Gölbaşı, Hakan; Ömeroğlu, İbrahim; Dereli Akdeniz, Didem; Ekin, Atalay; Gölbaşı, Ceren
Amaç: Çal›flmam›zda, proteinürisi olan veya olmayan hipertansif gebelerde perinatal ve neonatal sonuçlar› de¤erlendirmeyi amaçla- d›k. Spot üriner protein ile kreatinin oran›n›n (P/C) ve 24-saatlik protein at›l›m›n›n sonuçlar üzerindeki prediktivitesini karfl›laflt›r- d›k. Yöntem: Gebeli¤in 20. ve 37. haftalar› aras›nda yeni hipertansiyon tan›s› alm›fl 230 gebe retrospektif olarak çal›flmaya dahil edildi. Al›- nan 24 saatlik idrar ve P/C ile belirlenen protein seviyesine göre hastalar iki gruba ayr›ld›. Proteinüri varl›¤› ve seviyesi, P/C oran›y- la olan iliflkisi ve bu bulgular ile perinatal sonuçlar aras›ndaki iliflki de¤erlendirildi. Bulgular: Do¤um esnas›ndaki gestasyonel yafl ve gecikme dönemi (hipertansiyon tan›s› ile do¤um aras›ndaki süre), ?300 mg/24 saat ve P/C ?0.3 de¤erlerine sahip gebelerde anlaml› flekilde daha er- kendi. Advers neonatal sonuçlar, proteinürisi ?300 mg/24 saat ve P/C?0.3 olan hastalarda anlaml›yd›. 24 saatlik idrarda üriner pro- tein seviyeleri, P/C ?0.3 de¤erine sahip gebelerde anlaml› flekilde daha yüksekti ve 24 saatlik proteinüri ile P/C aras›nda anlaml› fle- kilde pozitif bir korelasyon bulundu (r=0.382, p<0.001). Sonuç: Çal›flmam›z, hipertansif gebelerde 24 saatte ?300 mg’lik bir protein kayb› ve spot idrarda ?0.3’lük bir P/C oran›n›n advers perinatal sonuçlarla iliflkili oldu¤unu ortaya koymufltur. Ayr›ca, hi- pertansif gebelerde ?300 mg/gün seviyesinde proteinürinin ve ?0.3’lük spot idrar P/C oran›n›n bu gebeleri erken do¤um riskine e¤ilimli k›ld›¤›n› tespit ettik.
Citation - WoS: 1
Citation - Scopus: 1
25-Hydroxyvitamin Levels in Sjögren’s Syndrome: Is It the Right Time to Dismiss the Case or Not
(Walter de Gruyter GmbH, 2024) Sımsır, Ilgın Yıldırım; Tanigor, Goksel; Karabulut, Gonca; Barutcuoglu, Burcu; Yılmaz, Zevcet
Objectives: This study aimed to investigate whether patients with primary Sjögren syndrome (SjS) have different levels of 25 OH-D3 (vitamin D) when compared to healthy populations and whether differences in 25 OH-D3 correlated with disease activity or markers. Methods: Eighty-eight female patients with SjS and 3,338 age-matched healthy female controls were included in this study. 25 OH-D3 levels were compared with healthy controls. Then the patients were stratified according to their 25 OH-D3 levels, either insufficient/deficient or normal (<50 nmol/L or ≥50 nmol/L). The disease activity was evaluated using The EULAR SjS disease activity index (ESSDAI) and its components. Correlation analyses were also performed for a possible correlation with disease characteristics and markers of activity. Results: No differences in 25 OH-D3 levels were found between SjS and healthy populations (p>0.05). No correla- tions were found between patient characteristics or labo- ratory values (p>0.05). Conclusions: This study did not find a link between disease characteristics and disease activity and 25 OH-D3 levels. Prospective studies with more patients should be conducted to reach a conclusion.
Citation - WoS: 2
Accidental Humor in Consecutive Interpreting: Accidentally Useful Food for Thought
(Istanbul Univ, Fac Letters, 2021) Yetkin Karakoç, Nihal
Unlike humor translation, humor in translation, caused by translation errors, is underresearched in translation studies. Accidental humor, as a subgroup of humor, has been analyzed in translation contexts, but to the best knowledge of the author, not in the interpreting context. This descriptive study, being the first of its kind dealing with the accidental humor in consecutive interpreting, is intended to fill the gap in the verbal manifestations of resources in the English-Turkish interpreting context along with the possible reasons for resources of accidental humor in consecutive interpreting class. As a result of the study, a total of 38 accidentally humorous instances are found. The verbal resources are analyzed and divided into main and sub-categories, and for each, examples from the corpus are discussed. In addition, new linguistic resources were discovered, which may be exclusive to this context. The detected items are by no means meant to be exhaustive, as also stated by the former studies, but nevertheless enables greater understanding about the types and possible causes of accidental humor which may occur during the consecutive interpreting process. Given the dearth of literature on accidental humor in consecutive interpreting, this study may provide some insight for remedial teaching/learning in interpreting studies, as well as linguistics. Future studies may examine, among the others, verbal resources in the simultaneous interpreting context and compare the verbal resources in depth in consecutive with those in simultaneous interpreting.
Citation - WoS: 6
Citation - Scopus: 5
Acrylamide-Encapsulated Glucose Oxidase Inhibits Breast Cancer Cell Viability
(Walter De Gruyter Gmbh, 2020) Rrustemi, Trendelina; Geyik, Oyku Gonul; Ozkaya, Ali Burak; Ozturk, Taylan Kurtulus; Yuce, Zeynep; Kilinc, Ali
Objectives: Cancer cells modulate metabolic pathways to ensure continuity of energy, macromolecules and redoxhomeostasis. Although these vulnerabilities are often targeted individually, targeting all with an enzyme may prove a novel approach. However, therapeutic enzymes are prone to proteolytic degradation and neutralizing antibodies leading to a reduced half-life and effectiveness. We hypothesized that glucose oxidase (GOX) enzyme that catalyzes oxidation of glucose and production of hydrogen peroxide, may hit all these targets by depleting glucose; crippling anabolic pathways and producing reactive oxygen species (ROS); unbalancing redox homeostasis. Methods: We encapsulated GOX in an acrylamide layer and then performed activity assays in denaturizing settings to determine protection provided by encapsulation. Afterwards, we tested the effects of encapsulated (enGOX) and free (fGOX) enzyme on MCF-7 breast cancer cells. Results: GOX preserved 70% of its activity following encapsulation. When fGOX and enGOX treated with guanidinium chloride, fGOX lost approximately 72% of its activity, while enGOX only lost 30%. Both forms demonstrated remarkable resilience against degradation by proteinase K and inhibited viability of MCF-7 cells in an activity-dependent manner. Conclusions: Encapsulation provided protection to GOX against denaturation without reducing its activity, which would prolong half-life of the enzyme when administered intravenously.
Citation - Scopus: 1
Affecting Factors in Medication Adherence in Kidney Transplant Recipients
(Aves, 2023) Ordin, Yaprak Sarigol; Karayurt, Ozgul; Ertan, Nermin; Edeer, Aylin Durmaz; Yildiz, Serkan
Objective: This study aimed to determine the risk factors related to immunosuppressive medication adherence in kidney transplant recipients. Methods: The study adopted a retrospective design. It was carried out on 208 kidney transplant recipients. The social cognitive theory was used for understanding and addressing the issues of nonadherence to immunosuppressive medication. Data were collected with a self-reported-Immunosuppressant Therapy Adherence Scale and biological assays. Descriptive analyses and logistic regression were used to analyze data. Results: According to the self-reported assessment, medication adherence of the patients receiving transplants from live donors was 0.503 times lower than that of the patients receiving transplants from deceased donors. The biological assays did not show any affecting factors in medication adherence. Conclusion: The results of the study showed the importance of combining methods to assess medication adherence. In the self-reported assessment, live donor transplantation was found to negatively affect medication adherence. Turkiye is the country with the highest number of kidney transplantations from live donors in the world. Health professionals must be more careful in assessing medication adherence after live donor transplantations.
Aile Hekimlerinin Sağlıklı Yaşam Biçimi Davranışlarının ve Klinik Uygulamalarında Yaşam Biçimi Tıbbının Değerlendirilmesi
(Galenos Publishing House, 2025) Semin, Ilgi; Kazdağlı, Hasan; Gökdemir, Özden
Amaç: Bu çalışmanın amacı, aile hekimlerinin sağlıklı yaşam biçimi davranışlarını değerlendirmek ve klinik uygulamalarında yaşam biçimi tıbbına yönelik katılımlarını incelemektir. Yöntemler: Temmuz 2018 ile Ağustos 2019 tarihleri arasında aile hekimlerinden veri toplamak amacıyla çevrimiçi bir anket geliştirildi. Tanımlayıcı ve korelasyonel bir araştırma deseni kullanıldı. Çalışmada uygulanan anket, “katılımcıların kişisel bilgileri” ve “Sağlıklı Yaşam Biçimleri Davranış Ölçeği-II”i içermektedir. Kesitsel bir çalışma olarak tasarlanan bu araştırmada, örneklem kolayda örnekleme metodu ile sekiz ülkeden belirlenmiştir, ve anketler katılımcılara elektronik ortamda uygulanmıştır. Katılımcılara anketin süresi, veri saklama işlemleri, saklama süresi, araştırmacıların kimliği ve çalışmanın amacı hakkında bilgi verilmiştir. Bulgular: Çalışmaya 131 aile hekimi katılmış olup, erkek katılımcı oranı daha yüksek bulunmuştur. Sigara içme sıklığının Türk aile hekimleri arasında anlamlı derecede yüksek olduğu tespit edilmiştir (p=0,013). Ancak, ölçek toplam puanı veya altı boyutta alınan puanlar açısından aile hekimleri arasında istatistiksel olarak anlamlı bir fark bulunmamıştır. Sonuç: Çoğu aile hekimi, bu alanda daha fazla eğitim almak istediklerini belirtmiştir, bu da tıp fakültelerinin müfredatına eğitim müdahalelerin dahil edilmesi gerekliliğini göstermektedir. Ayrıca, iyi yapılandırılmış web tabanlı kitlesel çevrimiçi kurslar, aile hekimlerinin sağlıklı yaşam biçimi davranışları ve yaşam biçimi tıbbı uygulamalarına yönelik eğitim gereksinimlerini karşılamada etkili bir çözüm olabilir.
Citation - WoS: 2
Citation - Scopus: 2
Analysis of Nucleotide Changes in Rt-Pcr Primer/Probe Binding Regions in Sars-Cov Isolates Reported From Turkey
(Ankara Microbiology Soc, 2021) Demir, Ayse Banu; Bulgurcu, Alihan; Appak, Ozgur; Sayiner, Ayca Arzu
The SARS-CoV-2 virus, which caused the COVID-19 epidemic, caused more than 55 million cases and nearly 1.5 million deaths worldwide. For the microbiological diagnosis of the disease, the most valid method is detecting the presence of the viral genome by real-time reverse transcription polymerase chain reaction (rRT-PCR). However, due to the nature of the RNA viruses, frequent mutations may affect the sensitivity of the analyses made on the genetic material of the virus, such as PCR. In this study, we aimed to investigate the mutations in the primer-probe binding regions of the rRT-PCR panels used in COVID-19 diagnosis. SARS-CoV-2 whole genome sequence data (n= 194) isolated from COVID-19 cases in Turkey and uploaded on GISAID database from the centers in Istanbul (n= 78), Ankara (n= 58), Kars (n= 47), Bursa (n= 2), Adiyaman (n= 2), Erciyes (n= 1) and Kocaeli (n= 1) between March 17-September 14, 2020 were analyzed. In order to determine the nucleotide changes, SARS-CoV-2 sequences from Turkey were compared to the reference genome sequence (NC_045512.1) present in GenBank website. The constructed data set was aligned using the MAFFT program and was checked manually if the sequences were in the same frame by using the AliView program. Primer-probe binding sites of the thirteen SARS-CoV-2 rRT-PCR panels from seven different institutes (US CDC, China CDC, Charite CDC, Pasteur, HKU, Thailand, NIID) that are being used in COVID-19 diagnosis were evaluated in terms of nucleotide changes within the corresponding regions compared to the reference genome. Sequence diversities in the viral genomes were determined via positional nucleotide numerical calculator and entropy calculator modules and nucleotide and entropy changes in primer-probe binding regions for each rRT-PCR panel were examined. Among thirteen different primer-probe panels, nucleotide changes in the target regions of the seven primer-probe panels were determined. When viral sequences with nucleotide changes in the primer-probe binding regions were examined, the most common changes were observed in the China CDC N-forward primer and US CDC N3-forward primer binding regions. It is important that the kits to be used as diagnostic tests are designed specific to the regions with less nucleotide changes. Nucleotide changes may not be critical for DNA amplification for most PCR panels, but should be carefully monitored as they may affect the sensitivity of the assay. If the risk of alteration of the designed region is high, the primer - probe binding sites should be checked frequently and updated when necessary.
Anxiety and Fear About Childbirth and Postpartum Period in Last Trimester and Its Relation To Childbirth Pain
(2022) Uğurlu, Meltem; Yavan, Tülay
Objective: This study aimed to determine the fear and anxiety related to childbirth and postpartum period in last trimester for pregnant women, and its relation to childbirth pain. Methods: This study was conducted in a training and research hospital’s obstetric clinic in Turkey. Totally, 104 pregnant women admitted to the hospital during the last trimester and they were followed up to delivery, which occurred in the same hospital. Data were gathered with an Information Form, Fear of Childbirth and Postpartum Anxiety Scale (FCPAS), Spielberger State and Trait Anxiety Inventory (STAI) and Visual Analogue Scale (VAS). Results: The mean FCPAS score of the women was 4.87±1.25. The highest scores were for the FCPAS subscales of fears about breastfeeding, behavior of the health staff at childbirth, and the possibility of Cesarean section. Labor pain had a significant positive weak relation with fear about childbirth and the total STAI-State score (r=0.281, p=0.041; r=0.327, p=0.017), respectively. Conclusion: It is important to determine the fear and anxieties about childbirth and postpartum period experienced during last trimester, in terms of planning prenatal education and counseling services, and supporting women to cope effectively.
Attitudes of Nursing Senior Students Towards the Use of Computers in Healthcare and Related Factors
(Association of Executive Nurses, 2022) Söylemez, B.A.; Özgül, E.; Akyol, M.A.; Küçükgüçlü, Ö.
Aim: This study was conducted to determine the attitudes of nursing senior students towards the use of computers in healthcare and related factors. Method: The descriptive and cross-sectional study was conducted with 162 senior nursing students in a faculty of nursing at a university between June and July 2021. Data were collected with the “Participant Information Form” and “Attitudes toward Computers in Healthcare Assessment Scale.” The SPSS 25.0 package program was used to evaluate the data. Socio-demographic data were given as numbers, mean, percentages, and standard deviation. Number, mean, percentage distributions, independent groups t-test, Mann Whitney-U test, One-way ANOVA test, and Pearson correlation test were used to analyze the data. Results: In this research, 67.9% of the 162 students were females, and the mean age was 22.43±1.50 years. The mean score of the students on the scale was 15.65±8.91. Status of owning a computer (t=2.729, p<0.01), frequency of computer usage (u=637.500, p<0.01), level of knowledge in using a computer (F=13.410, p<0.001), and status of computer use in nursing practices (t=4.244, p<0.001) were found to affect attitudes of nursing students towards the use of computers in healthcare. Conclusion: Senior nursing students were found to have a moderate attitude towards using computers in healthcare. Adopting more positive attitudes towards this area will increase the quality of nursing care and provide easier access to clinical data and charts. © 2022 The Authors.
AZERBAYCAN YERGİ EDEBİYATINDA BİR ZİRVE: MİRZA ALEKPER SABİR
(2017) Kuliyeva, Kübra
Edebî bir tür olarak yergi, gülmenin veya eğlenmenin ötesinde, eleştirmenin ve toplumdaki sorunlara, haksızlığa, adaletsizliğe, taassuba karşı durmanın bir aracı olmuştur. Bu bakımdan toplumda sorunların var olması eleştiriyi ve yergiyi doğurur. Yerginin amacı da insanların dikkatini bu sorunlara çekmek olduğu kadar aynı zamanda bu sorunları düzeltmeye çalışmaktır. Azerbaycan edebiyatında yerginin tarihi çok eskilere dayanmakla birlikte hem halk edebiyatında hem de klasik edebiyatta birçok yergi örneği bulmak mümkündür. Bu gelenek yakın geçmişimizde de bulunmaktadır. Bu örneklerin en önde geleni Mirza Alekper Sabir’in şiirleridir. Sabir Azerbaycan yergi edebiyatında eski anlayışı yaratıcılıkla geliştirerek yeni bir dönemin başlangıcı olmuştur. Şiirlerinde t opluma ayna tutan şair toplumda gördüğü bütün haksızlık, adaletsizlik, yanlış ve kötülükleri eleştirmiş hatta alaya almış ve bu yolla dikkati çekerek, bahsettiği sorun ve yolsuzlukların düzeltilmesi gerektiğini dile getirmiştir. Yaşadığı dönemde hak ettiği değeri göremeyen şair edebî kuvvetinin de farkında olduğu için tarzından vazgeçmemiş ve edebiyatın zirvesinde olacağını bilerek eser vermeye devam etmiştir.
Bakü-tiflis-ceyhan Boru Hattı Projesinin Hukuki Boyutları
(2012) Hekimoğlu, Mehmet Merdan
Kafkasya ve Orta Asya'daki zengin petrol ve doğal gaz yataklarının küreselleşen dünyadaki enerji ihtiyacının karşılanması için dünya pazarlarına sunulması, bölgedeki Türk devletlerinin ekonomik, sosyal ve siyasi gelişmelerinin sağlanması bakımından büyük bir önem taşımaktadır. Bakü-Tiflis-Ceyhan Boru Hattı projesi bu amacı gerçekleştirmeye yönelik ilk ciddi adımı meydana getirmektedir. Buna karşın söz konusu projenin hukuki çerçevesinin imzacı devletlerin lehine çizilebildiğini söylemek mümkün gözükmemektedir. Ancak büyük jeostratejik ve jeo-politik hedeflere ulaşılabilmesinin, bazen, sıra dışı hukuki yükümlülüklerle devletlerin kendilerini bağıtlamasını gerektirdiğinin de kabul edilmesi gerekir. Özellikle bölgede ilk defa böyle bir projenin gerçekleştirilecek olması, normal şartlar altında kabul edilmesi güç gözüken bir anormal hukuki yükümlülük rejimini doğallaştırmaktadır. Bununla birlikte, projenin hukuki temelini oluşturan "Transit Devlet Anlaşması" ile "Hükümetlerarası Anlaşmalar", uluslararası anlaşmalar hukukunca öngörülenin üzerinde bir sorumluluk rejimiyle imzacı devletleri uluslararası bir şirketler konsorsiyumuna karşı bağıtladığı için, bundan böyle yapılacak anlaşmaların hükümlerini hazırlarlarken bölge devletlerinin daha dengeli bir şekilde hareket etmeleri yerinde olacaktır.
Citation - Scopus: 2
Behavioral Immune System and Trypophobia
(Klinik Psikiyatri Dergisi, 2022) Ozturk, Suleyman; Ceylan, Deniz; Demir, Ayse Banu; Kazdagli, Hasan; Erdeniz, Burak
Pathogens, which are the source of infectious diseases, have imposed a strong selection pressure on human evo-lution as one of the most important causes of human death during the natural selection process. As a result of this, it is assumed that a variety of adaptations have evolved against infection threats and one of these adap-tations is the physiological immune system. However, activation of the physiological immune system can be quite costly for organisms in some cases, and therefore it has been recently proposed in evolutionary psychology that an adaptive system called behavioral immune sys-tem may have evolved in association with the proactive functional processes against pathogen threats. Furthermore, it was hypothesized that a number of psy-chopathologies might develop as a result of maladaptive processes affecting the functionality of this system, and one of these psychopathologies might be trypophobia. Trypophobia refers to a psychological disorder in which individuals experience aversion and disgust at excessive levels toward clusters of small objects such as holes and bumps. Following this, the current review was estab-lished within the framework of three distinct goals. Firstly, this review aimed to discuss the evolutionary basis and mechanisms of the behavioral immune system. Secondly, the review aimed to discuss the characteristic features and the etiological explanations of trypophobia. Finally, the review aimed to discuss how potential changes in the behavioral immune system might lead to the development of trypophobia.
A Brief Account of Language Teacher Training and Teaching From Other Countries
(2008) Üstünlüoğlu, Evrim
Yabancı dil öğretimi ve yabancı dil öğretmeni yetiştirme konuları yıllardır Türkiye’de sıklıkla tartışılan konular olmuştur. Harcanılan zamana, paraya ve çabaya rağmen yabancı dil öğretimi beklenilen sonuçları vermemiş ve dil öğrencileri kelime ve dil bilgisinin ötesine geçememişlerdir. Bu çalışmanın amacı farklı ülkelerdeki dil eğitimi ve dil öğretmeni yetiştirme yaklaşımlarını incelemek, bu yaklaşımları Türkiye’deki uygulamalarla karşılaştırmak ve Türkiye’de yabancı dil öğretimi ve yabancı dil öğretmeni yetiştirilmesinde nelerin yapılabileceğine yönelik önerilerde bulunmaktır. İngilizce dil öğretiminin daha küçük yaşlarda başlaması, İngilizce öğretmen yetiştirme programlarına Avrupa Birliği Çerçeve programlarının yansıtılması, öğretmenlerin bireysel gelişimlerinin önemsenmesi, ilkokul, lise ve üniversitede öğretim yapacak öğretmenlerin söz konusu düzeylere uygun olarak yetiştirilmesi ve öğretmenlik uygulamasının daha uzun süreli tutulması yapılan öneriler arasındadır.
Çeşitli Ülkelerdeki Kamu Özel Ortaklığı Uygulamalarının Hukuki Açıdan Değerlendirilmesi
(2011) Kasapoğlu Turhan, Mine
Kamu özel ortaklığı kavramı dünyada 1990'lı yıllarda ortaya çıkmıştır. Kamu özel ortaklığı (KÖO), idare ile özel sektör arasında uzun süreli bir sözleşme ilişkisine dayanan ve kamu hizmetlerinin görülmesine ve/ veya finansmanına idare ile özel sektörün birlikte katılmasını öngören, finansman, altyapı ve hizmet sağlama modellerinin tümü için kullanılan bir üst kavramdır. Türkiye'de bu kavram 3359 sayılı Sağlık Hizmetleri Temel Kanunu'na 2005 yılında eklenen bir madde (ek madde 7) ile gündeme gelmiştir. KÖO modelleri dünyanın birçok ülkesinde uygulanmaktadır. Bu kavram, küreselleşme ve liberal ekonomi politikalarının bir ürünüdür. Dünyadaki KÖO uygulamalarına bakıldığında, KÖO modelleri ile, kamu hizmeti alanının yeniden düzenlenerek, devletin kamu hizmetlerindeki rolünün daraltılmasının amaçlandığı görülür. KÖO'ların yaygınlaşmasıyla birlikte, devletin kamu hizmetleri alanındaki rolü, daha çok düzenleyici ve denetleyici bir role dönüşmektedir. Bu bağlamda, çeşitli ülkelerdeki KÖO uygulamalarının hukuki açıdan incelenmesi bir gereklilik arzetmektedir.
Çeviribilim Edimbilim İlişkisi Üzerine. İzmir, 2009: İzmir Ekonomi Üniversitesi Yayınları
(2010) Duman, Derya; Kansu Yetkiner, Neslihan
[Abstract Not Available]
Classification of Colon Cancer Patients Into Consensus Molecular Subtypes Using Support Vector Machines
(2023) Koçhan, Necla; Dayanç, Barış Emre
Background/aim: The molecular heterogeneity of colon cancer has made classification of tumors a requirement for effective treatment. One of the approaches for molecular subtyping of colon cancer patients is the consensus molecular subtypes (CMS), developed by the Colorectal Cancer Subtyping Consortium. CMS-specific RNA-Seq-dependent classification approaches are recent, with relatively low sensitivity and specificity. In this study, we aimed to classify patients into CMS groups using their RNA-seq profiles. Materials and methods: We first identified subtype-specific and survival-associated genes using the Fuzzy C-Means algorithm and log- rank test. We then classified patients using support vector machines with backward elimination methodology. Results: We optimized RNA-seq-based classification using 25 genes with a minimum classification error rate. In this study, we reported the classification performance using precision, sensitivity, specificity, false discovery rate, and balanced accuracy metrics. Conclusion: We present a gene list for colon cancer classification with minimum classification error rates and observed the lowest sensitivity but the highest specificity with CMS3-associated genes, which significantly differed due to the low number of patients in the clinic for this group.
Clinical Management Strategies of Cardiologists in Heart Failure with Reduced Ejection Fraction in Türkiye
(Kare Publ, 2024) Türk, Uğur Önsel; Kocabaş, Umut; Özçalık, Emre; Kıvrak, Tarık; Altın, Cihan
Amaç: Kalp yetersizliği (KY) kılavuz önerilerinin klinik pratikte uygulanması zaman almaktadır ve genellikle gerçek yaşam şartlarında optimal düzeyde uygulanmamaktadır. Bu zorluğun önemli nedenlerinden biri hekim ile ilişkili faktörlerdir. Bu anket çalışmasının amacı, Türkiye’deki kardiyoloji uzmanlarının düşük ejeksiyon fraksiyonlu kalp yetersizliği (DEF-KY) tedavi tercihlerini belirlemektir. Yöntem: Anket çalışması 22 sorudan oluşmaktadır. Bu sorular, SurveyMonkey üzerinden yayınlanmış ve anket katılım linki birçok sosyal medya aracı üzerinden hekimlere ulaştırılmıştır. Bulgular: Anket çalışmasına Türkiye’de görev yapmakta olan 177 kardiyoloji uzmanı ve asistanı katıldı. Katılımcıların ortalama yaşı 39.5, %73.3’ü erkek, %38.7’si eğitim ve araştırma hastanelerinde görev yapmakta idi ve sadece %10.2’si kendisini KY uzmanı olarak tanımlamaktaydı. Katılımcıların %80.1’i, DEF-KY tanısı için sınır ejeksiyon fraksiyonu değerini %40 olarak kabul ettiklerini belirttiler. Hekimlerin %52.6’sı anjiyotensin reseptör-neprilisin inhibitörü (ARNi) tedavisini ‘‘en etkili KY tedavisi’’ olarak kabul ettiklerini belirtmelerine karşın, %62.7’si ilacın geri ödeme kısıtlılıkları ve fiyatı nedeniyle, DEF-KY tedavisine ARNi yerine anjiyotensin dönüştürücü enzim inhibitörü (ADEi) ile başlamak zorunda kaldıklarını belirttiler. Katılımcıların %52.3’ü tedaviye farklı bir KY ilaç sınıfını eklemenin, halihazırda kullanılan ilaçların dozunu arttırmaktan daha önemli olduğunu belirttiler. Hekimlerin %69.5’i yeni tanı KY hastalarında, hastane yatışı sırasında dört KY ilaç sınıfını aynı anda başlamanın mümkün olduğunu belirttiler. Buna karşın günlük pratiklerinde, sırasıyla ADEi/ARNI, beta–bloker, mineralokortikoid reseptör antagonisti ve sodyum-glukoz ko-transporter 2 inhibitörlerini başladıkları sıralı yaklaşımı daha çok tercih ettiklerini belirttiler. Sonuç: Bu anket çalışması, kılavuz önerileri ile gerçek yaşam uygulamaları arasında önemli farklılıklar olduğunu ortaya koymaktadır. Kılavuz önerilerinin, klinik pratikte uygulanabilmesi için sağlık sağlayıcıların gerekli önlemleri almalarına ve düzenlemeleri yapmalarına ihtiyaç vardır.
Citation - WoS: 3
Citation - Scopus: 3
A Combination of Heart Rate-Corrected Qt Interval and Grace Risk Score Better Predict Early Mortality in Patients With Non-St Segment Elevation Acute Coronary Syndrome
(Aves, 2022) Inci, Saadet Demirtas; Tekindal, Mustafa Agah; Altinsoy, Meltem; Ozbeyaz, Nail Burak; Sunman, Hamza; Tas, Alperen; Yilmaz, Sabiye
Objective: This study aimed to evaluate whether the addition of heart rate-corrected QT interval prolongation to the Global Registry of Acute Coronary Events risk score improves the predictive value for early mortality in patients with non-ST segment elevation acute coronary syndrome. Methods: We retrospectively screened our database for consecutive non-ST-segment elevation acute coronary syndrome patients between January 2017 and July 2019. The demographic and clinical parameters were acquired via chart review. All electrocardiograms were reviewed by 2 physicians. QT interval was measured using the tangent method. Early mortality was defined as all-cause death observed during the hospital stay or within 30 days after discharge. Results: The final study population consisted of 283 patients, there were 17 early deaths. Ten of 59 patients with prolonged corrected QT intervals died (16.9%, P < .001). Both the Global Registry of Acute Coronary Events risk score (odds ratio: 1.032; 95% CI: 1.012-1.053; P = .002) and corrected QT interval (odds ratio: 1.026; 95% CI: 1.007-1.045; P = 0.007) independently predicted early mortality. The area under value was 0.769 (95% CI: 0.674-0.863, P < .001) for the corrected QT interval and 0.780 (95% CI:0.681-0.878; P < .001) for the Global Registry of Acute Coronary Events risk score alone. However, when the corrected QT interval and the Global Registry of Acute Coronary Events risk score were combined, it was found to be 0.808 (95% CI: 0.713-0.904, P < .001). Conclusion: This study is the first to report that prolonged corrected QT and the Global Registry of Acute Coronary Events risk score independently predict early mortality and a combination of these 2 factors may improve the predictive value for early mortality in patients with ST-segment elevation acute coronary syndrome.
Citation - WoS: 1
Citation - Scopus: 1
Comparison of Facial Palsy Cases Before and During the Pandemic Coronavirus Disease-2019
(Galenos Publ House, 2023) Uysal, Hasan Armağan; Güllüoğlu, Halil
Objective: The pandemic coronavirus disease-2019 (COVID-19) is caused by a novel type of coronavirus named severe acute respiratory syndrome coronavirus-2 and is rapidly spreading all over the world. In addition to various neurological symptoms, acute facial palsy was diagnosed as the main neurological symptom in some COVID-19 patients. The current study aimed to analyze the variation and any possible association in the case numbers or medical symptoms of patients with facial palsy before and during the COVID-19 pandemic.Methods: The clinical files of patients who were diagnosed with facial palsy in the Neurology Department of Medicalpoint Hospital, University of Economics Faculty of Medicine, Izmir were retrospectively investigated. To compare the facial palsy cases according to different periods, two patient groups were formed: before the COVID-19 pandemic and during the COVID-19 pandemic. The pandemic group was further divided into two subgroups as COVID-19-positive and COVID-19-negative patients to compare the effects of COVID-19 on facial palsy.Results: During the specified COVID-19 period (May 2020-January 2021) of the study, 38 patients were admitted to the hospital for facial palsy; 34 facial palsy patients were admitted in the same calendar period as the two previous years (May 2018-January 2019). There was no significant difference in the frequency of facial palsy between these two time periods. There were significant differences between before and during the COVID-19 pandemic groups regarding response to cortisone therapy (p<0.001), facial palsy grade (p<0.001), electromyography findings (p=0.005), denervation (p<0.001), and 6 months recovery (p<0.001) data. There were also significant differences between the COVID-19-positive and COVID-19-negative subgroups regarding response to cortisone therapy (p=0.015) and facial palsy grade (p=0.001).Conclusion: The current study findings support the possible association between the severity of the clinical course of facial palsy and COVID-19. Further studies are needed to prove a direct association between facial palsy and COVID-19.
Citation - Scopus: 1
Contradicting Parochial Realms in Neighborhood Parks: How the Park Attributes Shape Women’s Park Use
(Istanbul Teknik Universitesi, Faculty of Architecture, 2023) Kaştaş Uzun, İpek; Şenol, F.
Neighborhood parks are significant green public spaces located in close social and geographical proximity to homes to maintain individual and public health. However, some people do not use the nearest parks, but those with other socio-spatial attributes that make them feel more “familiar”. This study argues that with their facilities, amenities and design, and the surrounding land uses, neighborhood parks do not only accommodate, but also define, regulate, and originate social relations among users. Thus, the design and planning of urban public spaces play a role in the emergence and maintenance of supportive and conflictual relations that lead to familiarity. The study answers two research questions: How do the park attributes shape and mediate the interpersonal relations among the park users? How do gender differences influence the parochial realms in parks? Data was collected through field observations and in-depth interviews with 33 female users of two neighborhood parks in a populous district of Izmir (Turkey). Results state that women’s park visits were related to their gendered roles and responsibilities. Yet their responses point to challenges emerging from physical and social attributes of parks and park surroundings which lead to negotiations to protect their individual or group’s privacy (parochial realm) in neighborhood parks. Mainly, perceived threats to women’s parochial realm are men unaccompanied by child(ren), and exposure to the male gaze. The study highlights the importance of investigating these attributes of neighborhood parks for developing research and public policies to improve women’s presence and perceived safety in public settings. © 2023, Istanbul Teknik Universitesi, Faculty of Architecture. All rights reserved.

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